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Background: High-throughput proteomics techniques, such as mass spectrometry (MS)-based approaches, produce very high-dimensional data-sets. In a clinical setting one is often interested in how mass spectra differ between patients of…

We introduce a novel criterion in clustering that seeks clusters with limited range of values associated with each cluster's elements. In clustering or classification the objective is to partition a set of objects into subsets, called…

Data Structures and Algorithms · Computer Science 2018-05-15 Dorit S. Hochbaum

A clustering algorithm partitions a set of data points into smaller sets (clusters) such that each subset is more tightly packed than the whole. Many approaches to clustering translate the vector data into a graph with edges reflecting a…

Geometric Topology · Mathematics 2012-06-06 Jesse Johnson

A general scheme for divisive hierarchical clustering algorithms is proposed. It is made of three main steps : first a splitting procedure for the subdivision of clusters into two subclusters, second a local evaluation of the bipartitions…

Data Structures and Algorithms · Computer Science 2018-09-07 Maurice Roux

Many fields, such as neuroscience, are experiencing the vast proliferation of cellular data, underscoring the need for organizing and interpreting large datasets. A popular approach partitions data into manageable subsets via hierarchical…

Quantitative Methods · Quantitative Biology 2024-03-07 Diek W. Wheeler , Giorgio A. Ascoli

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level.…

In today's data-driven digital era, the amount as well as complexity, such as multi-view, non-Euclidean, and multi-relational, of the collected data are growing exponentially or even faster. Clustering, which unsupervisely extracts valid…

Machine Learning · Computer Science 2025-01-10 Zhao Kang , Xuanting Xie , Bingheng Li , Erlin Pan

The data stream model has been defined for new classes of applications involving massive data being generated at a fast pace. Web click stream analysis and detection of network intrusions are two examples. Cluster analysis on data streams…

Databases · Computer Science 2007-05-23 Zengyou He , Xiaofei Xu , Shengchun Deng , Joshua Zhexue Huang

Typing methods are widely used in the surveillance of infectious diseases, outbreaks investigation and studies of the natural history of an infection. And their use is becoming standard, in particular with the introduction of High…

Data Structures and Algorithms · Computer Science 2020-06-16 Cátia Vaz , Marta Nascimento , João A. Carriço , Tatiana Rocher , Alexandre P. Francisco

Data clustering is an approach to seek for structure in sets of complex data, i.e., sets of "objects". The main objective is to identify groups of objects which are similar to each other, e.g., for classification. Here, an introduction to…

Data Analysis, Statistics and Probability · Physics 2016-02-17 Alexander K. Hartmann

Clustering analysis plays an important role in scientific research and commercial application. K-means algorithm is a widely used partition method in clustering. However, it is known that the K-means algorithm may get stuck at suboptimal…

Neural and Evolutionary Computing · Computer Science 2014-05-26 M. H. Marghny , Rasha M. Abd El-Aziz , Ahmed I. Taloba

In cancer research, clustering techniques are widely used for exploratory analyses and dimensionality reduction, playing a critical role in the identification of novel cancer subtypes, often with direct implications for patient management.…

String barcoding is a recently introduced technique for genomic-based identification of microorganisms. In this paper we describe the engineering of highly scalable algorithms for robust string barcoding. Our methods enable distinguisher…

Data Structures and Algorithms · Computer Science 2016-08-31 Bhaskar DasGupta , Kishori M. Konwar , Ion I. Mandoiu , Alex A. Shvartsman

Spectral clustering approaches have led to well-accepted algorithms for finding accurate clusters in a given dataset. However, their application to large-scale datasets has been hindered by computational complexity of eigenvalue…

Machine Learning · Computer Science 2016-03-17 Shahzad Bhatti , Carolyn Beck , Angelia Nedic

Clustering is an important part of many modern data analysis pipelines, including network analysis and data retrieval. There are many different clustering algorithms developed by various communities, and it is often not clear which…

Machine Learning · Computer Science 2019-10-04 Maria-Florina Balcan , Travis Dick , Manuel Lang

The task of clustering a set of objects based on multiple sources of data arises in several modern applications. We propose an integrative statistical model that permits a separate clustering of the objects for each data source. These…

Machine Learning · Statistics 2015-12-01 Eric F. Lock , David B. Dunson

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Clustering large, mixed data is a central problem in data mining. Many approaches adopt the idea of k-means, and hence are sensitive to initialisation, detect only spherical clusters, and require a priori the unknown number of clusters. We…

Machine Learning · Statistics 2020-11-13 Joshua Tobin , Mimi Zhang

Clustering algorithms remain valuable tools for grouping and summarizing the most important aspects of data. Example areas where this is the case include image segmentation, dimension reduction, signals analysis, model order reduction,…

Numerical Analysis · Mathematics 2024-12-24 Guy B. Oldaker , Maria Emelianenko

A model-based approach is developed for clustering categorical data with no natural ordering. The proposed method exploits the Hamming distance to define a family of probability mass functions to model the data. The elements of this family…

Methodology · Statistics 2024-07-02 Raffaele Argiento , Edoardo Filippi-Mazzola , Lucia Paci