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The metabolism is the motor behind the biological complexity of an organism. One problem of characterizing its large-scale structure is that it is hard to know what to compare it to. All chemical reaction systems are shaped by the same…

Molecular Networks · Quantitative Biology 2011-05-10 Petter Holme , Mikael Huss , Sang Hoon Lee

In the following writing we discuss a conceptual framework for representing events and scenarios from the perspective of a novel form of causal analysis. This causal analysis is applied to the events and scenarios so as to determine…

Artificial Intelligence · Computer Science 2018-07-06 Anton Kolonin

The processes taking place inside the living cell are now understood to the point where predictive computational models can be used to gain detailed understanding of important biological phenomena. A key challenge is to extrapolate this…

Tissues and Organs · Quantitative Biology 2018-10-26 Stefan Engblom Daniel B. Wilson , Ruth E. Baker

The capability for environmental sound recognition (ESR) can determine the fitness of individuals in a way to avoid dangers or pursue opportunities when critical sound events occur. It still remains mysterious about the fundamental…

Neural and Evolutionary Computing · Computer Science 2019-02-05 Qiang Yu , Yanli Yao , Longbiao Wang , Huajin Tang , Jianwu Dang , Kay Chen Tan

Procedural text, which describes entities and their interactions as they undergo some process, depicts entities in a uniquely nuanced way. First, each entity may have some observable discrete attributes, such as its state or location;…

Computation and Language · Computer Science 2019-04-09 Aditya Gupta , Greg Durrett

The task of modelling and forecasting a dynamical system is one of the oldest problems, and it remains challenging. Broadly, this task has two subtasks - extracting the full dynamical information from a partial observation; and then…

Dynamical Systems · Mathematics 2022-08-16 Tyrus Berry , Suddhasattwa Das

Complex, multivariable systems are often analyzed by grouping their constituent units into components, sometimes referred to as latent features, which afford physical or biological interpretation. However, a priori many different types of…

Disordered Systems and Neural Networks · Physics 2026-05-01 Philipp Fleig , Ilya Nemenman

We study the problem of building generative models of natural source code (NSC); that is, source code written and understood by humans. Our primary contribution is to describe a family of generative models for NSC that have three key…

Programming Languages · Computer Science 2014-06-23 Chris J. Maddison , Daniel Tarlow

Relation of genome sizes to organisms complexity is still described rather equivocally. Neither the number of genes (G-value), nor the total amount of DNA (C-value) correlates consistently with phenotype complexity. Using information theory…

Genomics · Quantitative Biology 2007-05-23 Dmitri V. Parkhomchuk

Due to the complexity of the human body, most diseases present a high inter-personal variability in the way they manifest, i.e. in their phenotype, which has important clinical repercussions - as for instance the difficulty in defining…

Physics and Society · Physics 2018-06-06 Massimiliano Zanin , Juan Manuel Tuñas , Ernestina Menasalvas

Empirical evidence suggesting that living systems might operate in the vicinity of critical points, at the borderline between order and disorder, has proliferated in recent years, with examples ranging from spontaneous brain activity to…

Statistical Mechanics · Physics 2014-07-25 Jorge Hidalgo , Jacopo Grilli , Samir Suweis , Miguel A. Munoz , Jayanth R. Banavar , Amos Maritan

Living organisms are not just random collections of organic molecules. There is continuous information processing going on in the apparent bouncing around of molecules of life. Optimisation criteria in this information processing can be…

Quantum Physics · Physics 2007-05-23 Apoorva Patel

The problem of selection, storage, search and analysis of information about the state, functioning and interaction of elements of complex hierarchical network systems is considered. The principles of construction of information models of…

Physics and Society · Physics 2021-06-17 Olexandr Polishchuk , Mykhailo Yadzhak

The fast changing reality in technical and natural domains perceived by always more accurate observations has drawn attention on new and very broad class of systems with specific behaviour represented under the common wording complexity.…

Adaptation and Self-Organizing Systems · Physics 2007-06-06 Michel Cotsaftis

This article introduces the physics of information in the context of molecular biology and genomics. Entropy and information, the two central concepts of Shannon's theory of information and communication, are often confused with each other…

Biomolecules · Quantitative Biology 2007-05-23 Christoph Adami

The complexity of condensed matter arises from emergent behaviors that cannot be understood by analyzing individual constituents in isolation. While traditional condensed-matter approaches-developed primarily for ideal crystalline…

Materials Science · Physics 2025-09-30 Elisabetta Nocerino

The standard assumptions that underlie many conceptual and quantitative frameworks do not hold for many complex physical, biological, and social systems. Complex systems science clarifies when and why such assumptions fail and provides…

Physics and Society · Physics 2020-11-11 Alexander F. Siegenfeld , Yaneer Bar-Yam

This paper discusses the latest generation of the MONARC (MOdels of Networked Analysis at Regional Centers) simulation framework, as a design and modelling tool for large scale distributed systems applied to HEP experiments. A…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-06-28 Ciprian Dobre , Corina Stratan

Modeling environmental ecosystems is essential for effective resource management, sustainable development, and understanding complex ecological processes. However, traditional methods frequently struggle with the inherent complexity,…

Machine Learning · Computer Science 2025-03-06 Runlong Yu , Shengyu Chen , Yiqun Xie , Xiaowei Jia

Sparse autoencoders (SAEs) have lately been used to uncover interpretable latent features in large language models. By projecting dense embeddings into a much higher-dimensional and sparse space, learned features become disentangled and…

Machine Learning · Computer Science 2025-07-30 Viktoria Schuster