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We present a novel microfluidic method to produce quasi-monodisperse bubbles with diameters from tens to very few microns. A gaseous rivulet flows over the shallow groove printed on a T-junction exit channel. The triple contact line…

Fluid Dynamics · Physics 2025-04-04 A. Rubio , S. Rodríguez-Aparicio , J. M. Montanero , M. G. Cabezas

Microcapsules with liquid cores encapsulated by thin membranes have many applications in science, medicine and industry. In this paper, we design a suspension of microcapsules which flow and deform like red blood cells (RBCs), as a valuable…

Soft Condensed Matter · Physics 2023-02-22 Qi Chen , Naval Singh , Kerstin Schirrmann , Qi Zhou , Igor Chernyavsky , Anne Juel

Micromanipulations, perfusions and measurements performed using glass microelectrodes filled with an electrolyte is a conventional technique for experimental morphological and membrane electrophysiological studies at a single cell and…

Subcellular Processes · Quantitative Biology 2018-07-27 O. V. Gradov , P. A. Nasirov , A. A. Scrynnic , A. G. Jablokov

Optofluidic devices have revolutionized the manipulation and transportation of fluid at smaller length scales ranging from micrometers to millimeters. We describe a dedicated optical setup for studying laser-induced cavitation inside a…

This work describes a new microfluidic device developed for rapid screening of solubility diagrams. In several parallel channels, hundreds of nanoliter-volume droplets of a given solution are first stored with a gradual variation in the…

Soft Condensed Matter · Physics 2007-05-23 P. Laval , N. Lisai , J. -B. Salmon , M. Joanicot

We report on experiments that consist in deforming a collection of monodisperse droplets produced by a microfluidic chip through a flow-focusing device. We show that a proper numerical modelling of the flow is necessary to access the stress…

Soft Condensed Matter · Physics 2018-05-23 Corentin Trégouët , Thomas Salez , Cécile Monteux , Mathilde Reyssat

The production of monodisperse particles or droplets is a longstanding issue across various fields, from aerosol science to inkjet printing. In bioengineering, submillimeter cell laden hydrogel capsules have proven valuable for developing…

Fluid Dynamics · Physics 2025-03-28 Lucas Suire , Anirban Jana , Pierre Nassoy , Amaury Badon

Blood-mimicking fluids (BMFs) play a critical role in ultrasonic imaging and Doppler flow studies by replicating the physical and acoustic properties of blood. This study introduces a novel soybean oil-in-water emulsion as a BMF with…

Cell spheroids are in vitro multicellular model systems that mimic the crowded micro-environment of biological tissues. Their mechanical characterization can provide valuable insights in how single-cell mechanics and cell-cell interactions…

Quantitative Methods · Quantitative Biology 2022-11-21 R. C. Boot , A. Roscani , L. van Buren , S. Maity , G. H. Koenderink , P. E. Boukany

We present Tuna-step, a novel microfluidic module based on step emulsification that allows for reliable generation of droplets of different sizes. Until now, sizes of droplets generated with step emulsification were hard-wired into the…

This study investigates the hydrodynamics of droplet formation in a T-shaped cylindrical microfluidic device using micro-PIV experiments and CFD simulations. Devices of 150 micro-m internal diameter were fabricated from PDMS via a…

Fluid Dynamics · Physics 2026-03-04 Pratibha Dogra , Ram Prakash Bharti , Gaurav Sharma

For high-throughput cell culture and associated analytics, droplet-based cultivation systems open up the opportunities for parallelization and rapid data generation. In contrast to microfluidics with continuous flow, sessile droplet…

The encapsulation and co-encapsulation of particles in microfluidic flows is essential in applications related to single-cell analysis and material synthesis. However, the whole encapsulation process is stochastic in nature, and its…

Fluid Dynamics · Physics 2022-06-20 Keshvad Shahrivar , Francesco Del Giudice

Microfluidics is an established multidisciplinary research domain with widespread applications in the fields of medicine, biotechnology and engineering. Conventional production methods of microfluidic chips have been limited to planar…

Most commercial microfluidic droplet generators rely on the planar flow-focusing configuration implemented in polymer or glass chips. The planar geometry, however, suffers from many limitations and drawbacks, such as the need of specific…

Fluid Dynamics · Physics 2020-12-14 Adrien Dewandre , Javier Rivero-Rodriguez , Youen Vitry , Benjamin Sobac , Benoit Scheid

Microfluidic devices are increasingly used in synchrotron-based experiments to deliver and probe liquid samples, offering advantages such as minimal sample consumption and reduced radiation damage. Despite their growing use, few devices…

Laser writing of materials is normally performed by the sequential scanning of a single focused beam across a sample. This process is time-consuming and it can severely limit the throughput of laser systems in key applications such as…

Applied Physics · Physics 2019-07-22 A. Zunino , S. Surdo , M. Duocastella

In microfluidic systems, droplets undergo intricate deformations as they traverse flow-focusing junctions, posing a challenging task for accurate measurement, especially during short transit times. This study investigates the physical…

In this study, capillary-driven flow of different pure liquids and diluted bitumen samples were studied using microfluidic channel (width of 30 um and depth of 9 um). Capillary filling kinetics of liquids as a function of time were…

Soft Condensed Matter · Physics 2016-12-01 Kiarash Keshmiri , Saeed Mozaffari , Plamen Tchoukov , Haibo Huang , Neda Nazemifard

Capillary-driven transport offers a simple, self-sustained alternative to externally pumped microfluidic systems, yet achieving precise control of such flows remains challenging. We experimentally and theoretically investigate capillary…

Fluid Dynamics · Physics 2026-03-03 Harsha Desu , Niladri S. Satpathi , Lokesh Malik , Ashis K. Sen