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In this paper, based on geometric singular perturbation analysis of a quasi-one dimensional Poisson-Nernst-Planck model for ionic flows, we study the problem of zero current condition for ionic flows through membrane channels with a simple…

Dynamical Systems · Mathematics 2020-09-22 Hamid Mofidi , Weishi Liu

This work examines the geometric mean of concentrations and its behavior in various situations, as well as the reversal permanent charge problem, the charge sharing seen in x-ray diffraction. Observations are obtained from analytical…

Statistical Mechanics · Physics 2020-09-22 Hamid Mofidi

The main goal of this work is to examine the qualitative effect of ion sizes via a steady-state boundary value problem. We study a one-dimensional version of a Poisson-Nernst-Planck system with a local hard-sphere potential model for ionic…

Mathematical Physics · Physics 2022-03-18 Weishi Liu , Hamid Mofidi

In this work, we examine effects of large permanent charges on ionic flow through ion channels based on a quasi-one dimensional Poisson-Nernst-Planck model. It turns out large positive permanent charges inhibit the flux of cation as…

Quantitative Methods · Quantitative Biology 2017-12-20 Liwei Zhang , Bob Eisenberg , Weishi Liu

In this paper, we study effects of permanent charges on ion flows through membrane channels via a quasi-one-dimensional classical Poisson-Nernst-Planck system. This system includes three ion species, two cations with different valences and…

Soft Condensed Matter · Physics 2023-12-07 Ning Sun , Weishi Liu

The flow of ions through permeable channels causes voltage drop in physiological nanodomains such as synapses, dendrites and dendritic spines, and other protrusions. How the voltage changes around channels in these nanodomains has remained…

Soft Condensed Matter · Physics 2025-01-10 Frédéric Paquin-Lefebvre , David Holcman

Ionic flow carries electrical signals for cells to communicate with each other. The permanent charge of an ion channel is a crucial protein structure for flow properties while boundary conditions play a role of the driving force. Their…

Numerical Analysis · Mathematics 2021-06-09 Weizhang Huang , Weishi Liu , Yufei Yu

We investigate the effects of the relative dielectric coefficient on ionic flows in open ion channels, using mathematical analysis of reasonably general Poisson-Nernst-Planck type models that can include the finite sizes of ions. The value…

Biomolecules · Quantitative Biology 2017-10-03 Bob Eisenberg , Weishi Liu

A model of mobile, charged ion channels in a fluid membrane is studied. The channels may switch between an open and a closed state according to a simple two-state kinetics with constant rates. The effective electrophoretic charge and the…

Soft Condensed Matter · Physics 2009-11-07 Stephan C. Kramer , Reiner Kree

A simple theory of ion permeation through a channel is presented, in which diffusion occurs according to Fick's law and drift according to Ohm's law, in the electric field determined by all the charges present. This theory accounts for…

Biomolecules · Quantitative Biology 2016-10-17 Bob Eisenberg

In this research, we explore how permanent charges affect the movement of ionic currents through ion channels. We use a quasi-one-dimensional classical Poisson-Nernst-Planck (PNP) model to study two types of ions, one positively charged and…

Dynamical Systems · Mathematics 2023-12-29 Hamid Mofidi

This study investigates the flux ratios of ionic flows using Poisson-Nernst-Planck (PNP) models. The flux ratio measures the effect of permanent charge on the ion fluxes and can exhibit bifurcation, where a small parameter change causes a…

Dynamical Systems · Mathematics 2023-11-07 Hamid Mofidi

We investigate Ussing's unidirectional fluxes and flux ratios of charged tracers motivated particularly by the insightful proposal of Hodgkin and Keynes on a relation between flux ratios and channel structure. Our study is based on analysis…

Other Quantitative Biology · Quantitative Biology 2016-12-30 Shuguan Ji , Bob Eisenberg , Weishi Liu

We demonstrate with computer simulations that anomalous electrokinetic effects, such as ion specificity and non-zero zeta potentials for uncharged surfaces, are generic features of electro-osmotic flow in hydrophobic channels. This behavior…

Soft Condensed Matter · Physics 2009-11-13 David M. Huang , Cecile Cottin-Bizonne , Christophe Ybert , Lyderic Bocquet

The bulk nuclear matter produced in heavy ion collisions carries a multitude of conserved quantum numbers: electric charge, baryon number, and strangeness. Therefore, the diffusion processes associated to these conserved charges cannot…

High Energy Physics - Phenomenology · Physics 2020-04-15 Jan A. Fotakis , Moritz Greif , Gabriel Denicol , Harri Niemi , Carsten Greiner

We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have…

Cell Behavior · Quantitative Biology 2015-02-20 D. Andreucci , D. Bellaveglia , E. N. M. Cirillo , S. Marconi

Experiments on single ionic channels have contributed to a large extent to our current view on the function of cell membrane. In these experiments the main observables are the physical quantities: ionic concentration, membrane electrostatic…

Biological Physics · Physics 2018-04-17 Laureano Ramírez-Piscina , José M. Sancho

We present a hydrodynamic theory describing pair diffusion in systems with periodic boundary conditions, thereby generalizing earlier work on self-diffusion [D\"unweg and Kremer, J. Chem. Phys. 1993, 99, 6983-6997; Yeh and Hummer, J. Phys.…

Soft Condensed Matter · Physics 2023-05-03 Diddo Diddens , Andreas Heuer

Recent experiments (F.H.J. Van Der Heyden et al., PRL 96, 224502 (2006)) of streaming currents in silica nanochannels with divalent ions report charge inversion, i.e. interfacial charges attracting counterions in excess of their own nominal…

Materials Science · Physics 2007-06-26 Christian D. Lorenz , Alex Travesset

Diffusion of point-like non interacting particles in a two-dimensional (2D) channel of varying cross section is considered. The particles are biased by a constant force in the transverse direction. We apply our recurrence mapping procedure,…

Statistical Mechanics · Physics 2015-05-28 Pavol Kalinay
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