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Transmission rates are key in understanding the spread of infectious diseases. Using the framework of compartmental models, we introduce a simple method that enables us to reconstruct time series of transmission rates directly from…

Quantitative Methods · Quantitative Biology 2016-05-06 Alexander Lange

Accurate and reliable predictions of infectious disease dynamics can be valuable to public health organizations that plan interventions to decrease or prevent disease transmission. A great variety of models have been developed for this…

Machine Learning · Statistics 2018-07-04 Evan L. Ray , Nicholas G. Reich

Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between…

In this manuscript, we use meteorological information in Galicia (Spain) to propose a novel approach to predict the incidence of influenza. Our approach extends the GLS methods in the multivariate framework to functional regression models…

We present a machine learning-based methodology capable of providing real-time ("nowcast") and forecast estimates of influenza activity in the US by leveraging data from multiple data sources including: Google searches, Twitter microblogs,…

Applications · Statistics 2016-02-17 Mauricio Santillana , Andre T. Nguyen , Mark Dredze , Michael J. Paul , John S. Brownstein

Background: Influenza A/H3N2 has been circulating in humans since 1968, causing considerable morbidity and mortality. Although H3N2 incidence is highly seasonal, how such seasonality contributes to global phylogeographic migration dynamics…

Populations and Evolution · Quantitative Biology 2015-02-06 Daniel Zinder , Trevor Bedford , Edward B. Baskerville , Robert J. Woods , Manojit Roy , Mercedes Pascual

Much traditional statistical modelling assumes that the outcome variables of interest are independent of each other when conditioned on the explanatory variables. This assumption is strongly violated in the case of infectious diseases,…

Populations and Evolution · Quantitative Biology 2019-11-28 Timothy Kinyanjui , Thomas House

This article reviews quantitative methods to estimate the basic reproduction number of pandemic influenza, a key threshold quantity to help determine the intensity of interventions required to control the disease. Although it is difficult…

Populations and Evolution · Quantitative Biology 2009-11-13 Gerardo Chowell , Hiroshi Nishiura

In this paper, we present a new approach to time series forecasting. Time series data are prevalent in many scientific and engineering disciplines. Time series forecasting is a crucial task in modeling time series data, and is an important…

Machine Learning · Computer Science 2020-01-24 Neo Wu , Bradley Green , Xue Ben , Shawn O'Banion

Influenza, an infectious disease, causes many deaths worldwide. Predicting influenza victims during epidemics is an important task for clinical, hospital, and community outbreak preparation. On-line user-generated contents (UGC), primarily…

Computers and Society · Computer Science 2021-04-15 Taichi Murayama , Nobuyuki Shimizu , Sumio Fujita , Shoko Wakamiya , Eiji Aramaki

Influenza epidemics result in a public health and economic burden around the globe. Traditional surveillance techniques, which rely on doctor visits, provide data with a delay of 1-2 weeks. A means of obtaining real-time data and…

Populations and Evolution · Quantitative Biology 2019-04-11 Wendy K. Caldwell , Geoffrey Fairchild , Sara Y. Del Valle

Evidence-based knowledge of infectious disease burden, including prevalence, incidence, severity and transmission, in different population strata and locations, and possibly in real time, is crucial to the planning and evaluation of public…

Methodology · Statistics 2018-08-14 Daniela De Angelis , Anne M. Presanis

Diffusion processes in networks are increasingly used to model the spread of information and social influence. In several applications in computational sustainability such as the spread of wildlife, infectious diseases and traffic mobility…

Social and Information Networks · Computer Science 2013-09-27 Akshat Kumar , Daniel Sheldon , Biplav Srivastava

Influenza A is responsible for 290,000 to 650,000 respiratory deaths a year, though this estimate is an improvement from years past due to improvements in sanitation, healthcare practices, and vaccination programs. In this study, we perform…

Machine Learning · Computer Science 2025-07-29 Edmund F. Agyemang , Hansapani Rodrigo , Vincent Agbenyeavu

The Influenza type A virus can be considered as one of the most severe viruses that can infect multiple species with often fatal consequences to the hosts. The Haemagglutinin (HA) gene of the virus has the potential to be a target for…

Quantitative Methods · Quantitative Biology 2021-02-16 Charalambos Chrysostomou , Harris Partaourides , Huseyin Seker

Infectious disease models can be of great use for understanding the underlying mechanisms that influence the spread of diseases and predicting future disease progression. Modeling has been increasingly used to evaluate the potential impact…

Applications · Statistics 2019-08-20 Md Mahsin , Rob Deardon , Patrick Brown

Background: The pandemic of influenza A (H1N1) is a serious on-going global public crisis. Understanding its spreading dynamics is of fundamental importance for both public health and scientific researches. Recent studies have focused…

Physics and Society · Physics 2015-03-13 Xiao-Pu Han , Bing-Hong Wang , Chang-Song Zhou , Tao Zhou , Jun-Fang Zhu

How important is resource depletion (e.g. depletion of target cells) in controlling infection within a host? And how can we distinguish between resource depletion and other mechanisms that may contribute to decline of pathogen load or lead…

Cell Behavior · Quantitative Biology 2017-05-09 Hasan Ahmed , James Moore , Balaji Manicassamy , Adolfo Garcia-Sastre , Andreas Handel , Rustom Antia

Infectious diseases pose significant human and economic burdens. Accurately forecasting disease incidence can enable public health agencies to respond effectively to existing or emerging diseases. Despite progress in the field, developing…

Machine Learning · Computer Science 2024-09-04 Michael Morris

Mathematical models of epidemic dynamics offer significant insight into predicting and controlling infectious diseases. The dynamics of a disease model generally follow a susceptible, infected, and recovered (SIR) model, with some standard…

Populations and Evolution · Quantitative Biology 2013-11-28 Caitlyn Witkowski , Brian Blais