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Material decomposition in X-ray imaging uses the energy-dependence of attenuation to virtually decompose an object into specific constituent materials. X-ray phase contrast imaging is a developing technique that can enhance image contrast…

X-ray energy spectrum plays an essential role in computed tomography (CT) imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of spectrum estimation methods are indirect and usually suffered from various…

Medical Physics · Physics 2017-06-14 Wei Zhao , Lei Xing , Qiude Zhang , Qingguo Xie , Tianye Niu

In high-performance computing (HPC) environments, particularly in synchrotron radiation facilities, vast amounts of X-ray images are generated. Processing large-scale X-ray Computed Tomography (X-CT) datasets presents significant…

Image and Video Processing · Electrical Eng. & Systems 2026-02-19 Amarjit Singh , Kento Sato , Kohei Yoshida , Kentaro Uesugi , Yasumasa Joti , Takaki Hatsui , Andrès Rubio Proaño

X-ray energy spectrum plays an essential role in imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of the spectrum estimation methods are indirect and are usually suffered from various limitations. The…

Medical Physics · Physics 2016-04-19 Wei Zhao , Qiude Zhang , Tianye Niu

Photon-counting computed tomography (PCCT) has emerged as a promising imaging technique, enabling spectral imaging and material decomposition (MD). However, images typically suffer from a low signal-to-noise ratio (SNR) due to constraints…

Optical Coherence Tomography (OCT) is an emerging technique in the field of biomedical imaging, with applications in ophthalmology, dermatology, coronary imaging etc. Due to the underlying physics, OCT images usually suffer from a granular…

Computer Vision and Pattern Recognition · Computer Science 2015-02-10 Ahmadreza Baghaie , Roshan M. D'souza , Zeyun Yu

Many spectral CT applications require accurate material decomposition. Existing material decomposition algorithms are often susceptible to significant noise magnification or, in the case of one-step model-based approaches, hampered by slow…

Medical Physics · Physics 2025-07-22 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Spectral CT offers enhanced material discrimination over single-energy systems and enables quantitative estimation of basis material density images. Water/iodine decomposition in contrast-enhanced CT is one of the most widespread…

Medical Physics · Physics 2021-03-30 Matthew Tivnan , Grace Gang , Wenchao Cao , Nadav Shapira , Peter B. Noel , J. Webster Stayman

Dual-energy computed tomography (DECT) has shown great potential and promising applications in advanced imaging fields for its capabilities of material decomposition. However, image reconstructions and decompositions under sparse views…

Medical Physics · Physics 2016-08-01 Lei Li , Ailong Cai , Linyuan Wang , Bin Yan , Hanming Zhang , Zhizhong Zheng , Wenkun Zhang , Wanli Lu , Guoen Hu

Photon-counting spectral computed tomography is now clinically available. These new detectors come with the promise of higher contrast-to-noise ratio and spatial resolution and improved low-dose imaging. However, one important design…

Medical Physics · Physics 2023-02-03 Dennis Hein , Konstantinos Liappis , Fredrik Grönberg , Alma Eguizabal , Mats Persson

In this work, we introduce a new deep learning approach based on diffusion posterior sampling (DPS) to perform material decomposition from spectral CT measurements. This approach combines sophisticated prior knowledge from unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2024-02-07 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Spectral CT has great potential for a variety of clinical applications due to the improved material discrimination with respect to conventional CT. Many clinical and preclinical spectral CT systems have two spectral channels for dual-energy…

Medical Physics · Physics 2020-10-17 Matthew Tivnan , Wenying Wang , J. Webster Stayman

Multi-spectral CT (MSCT) is increasingly used in industrial non-destructive testing and medical diagnosis because of its outstanding performance like material distinguishability. The process of obtaining MSCT data can be modeled as…

Numerical Analysis · Mathematics 2023-06-28 Huiying Pan , Shusen Zhao , Weibin Zhang , Huitao Zhang , Xing Zhao

This paper introduces ROI-Packing, an efficient image compression method tailored specifically for machine vision. By prioritizing regions of interest (ROI) critical to end-task accuracy and packing them efficiently while discarding less…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Md Eimran Hossain Eimon , Alena Krause , Ashan Perera , Juan Merlos , Hari Kalva , Velibor Adzic , Borko Furht

Dual energy CT (DECT) enhances tissue characterization because it can produce images of basis materials such as soft-tissue and bone. DECT is of great interest in applications to medical imaging, security inspection and nondestructive…

Medical Physics · Physics 2018-09-05 Qiaoqiao Ding , Tianye Niu , Xiaoqun Zhang , Yong Long

Recent development of photon-counting CT (PCCT) brings great opportunities for plaque characterization with much-improved spatial resolution and spectral imaging capability. While existing coronary plaque PCCT imaging results are based on…

Medical Physics · Physics 2023-12-05 Mengzhou Li , Mingye Wu , Jed Pack , Pengwei Wu , Bruno De Man , Adam Wang , Koen Nieman , Ge Wang

Dual energy computed tomography (DECT) imaging plays an important role in advanced imaging applications due to its material decomposition capability. Image-domain decomposition operates directly on CT images using linear matrix inversion,…

Image and Video Processing · Electrical Eng. & Systems 2019-08-20 Zhipeng Li , Saiprasad Ravishankar , Yong Long , Jeffrey A. Fessler

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…

Medical Physics · Physics 2018-03-19 Wei Zhao , Don Vernekohl , Fei Han , Bin Han , Hao Peng , Lei Xing , James K Min

This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…

Spectral Photon-Counting Computed Tomography (SPCCT) is a promising technology that has shown a number of advantages over conventional X-ray Computed Tomography (CT) in the form of material separation, artefact removal and enhanced image…

Image and Video Processing · Electrical Eng. & Systems 2020-03-10 Dimitris Kamilis , Mario Blatter , Nick Polydorides