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Medical image segmentation is crucial for accurate clinical diagnoses, yet it faces challenges such as low contrast between lesions and normal tissues, unclear boundaries, and high variability across patients. Deep learning has improved…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Houze Liu , Tong Zhou , Yanlin Xiang , Aoran Shen , Jiacheng Hu , Junliang Du

Efficient and easy segmentation of images and volumes is of great practical importance. Segmentation problems that motivate our approach originate from microscopy imaging commonly used in materials science, medicine, and biology. We…

Computer Vision and Pattern Recognition · Computer Science 2020-09-29 Vedrana Andersen Dahl , Monica Jane Emerson , Camilla Himmelstrup Trinderup , Anders Bjorholm Dahl

We study the problems of multi-person pose segmentation in natural images and instance segmentation in biological images with crowded cells. We formulate these distinct tasks as integer programs where variables correspond to poses/cells. To…

Computer Vision and Pattern Recognition · Computer Science 2016-12-02 Shaofei Wang , Chong Zhang , Miguel A. Gonzalez-Ballester , Julian Yarkony

This technical report analyzes non-contrast CT image segmentation in computer vision. It revisits a proposed method, examines the background of non-contrast CT imaging, and highlights the significance of segmentation. The study reviews…

Image and Video Processing · Electrical Eng. & Systems 2025-03-12 Canxuan Gang , Yuhan Peng

Image segmentation is a central topic in image processing and computer vision and a key issue in many applications, e.g., in medical imaging, microscopy, document analysis and remote sensing. According to the human perception, image…

Numerical Analysis · Mathematics 2022-06-24 Laura Antonelli , Valentina De Simone , Daniela di Serafino

Mitochondria segmentation in electron microscopy images is essential in neuroscience. However, due to the image degradation during the imaging process, the large variety of mitochondrial structures, as well as the presence of noise,…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Zhili Li , Xuejin Chen , Jie Zhao , Zhiwei Xiong

Structured illumination can reject out-of-focus signal from a sample, enabling high-speed and high-contrast imaging over large areas with widefield detection optics. Currently, this optical-sectioning technique is limited by image…

High-content screening (HCS) assays based on high-throughput microscopy techniques such as Cell Painting have enabled the interrogation of cells' morphological responses to perturbations at an unprecedented scale. The collection of such…

Machine Learning · Computer Science 2025-09-25 Mingyu Lu , Ethan Weinberger , Chanwoo Kim , Su-In Lee

Microscopy imaging plays a vital role in understanding many biological processes in development and disease. The recent advances in automation of microscopes and development of methods and markers for live cell imaging has led to rapid…

Computer Vision and Pattern Recognition · Computer Science 2017-05-10 Saad Ullah Akram , Juho Kannala , Lauri Eklund , Janne Heikkilä

Accurate cell counting in microscopic images is important for medical diagnoses and biological studies. However, manual cell counting is very time-consuming, tedious, and prone to subjective errors. We propose a new density regression-based…

Computer Vision and Pattern Recognition · Computer Science 2019-03-25 Shenghua He , Kyaw Thu Minn , Lilianna Solnica-Krezel , Hua Li , Mark Anastasio

The mechanical properties of PC12 living cells have been studied at the nanoscale with a Force Feedback Microscope using two experimental approaches. Firstly, the local mechanical impedance of the cell membrane has been mapped…

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical…

In digital pathology, both detection and classification of cells are important for automatic diagnostic and prognostic tasks. Classifying cells into subtypes, such as tumor cells, lymphocytes or stromal cells is particularly challenging.…

Computer Vision and Pattern Recognition · Computer Science 2022-06-07 Shahira Abousamra , David Belinsky , John Van Arnam , Felicia Allard , Eric Yee , Rajarsi Gupta , Tahsin Kurc , Dimitris Samaras , Joel Saltz , Chao Chen

Numerous physical phase plates (PP) for phase-contrast enhancement in transmission electron microscopy (TEM) have been proposed and studied with the hole-free or Volta PP having a high impact and interest in recent years. This study is…

Instrumentation and Detectors · Physics 2021-05-25 Simon Hettler , Raul Arenal

Stem cells, through their ability to produce daughter stem cells and differentiate into specialized cells, are essential in the growth, maintenance, and repair of biological tissues. Understanding the dynamics of cell populations in the…

Applications · Statistics 2026-02-02 Huyen Nguyen , Haim Bar , Zhiyi Chi , Vladimir Pozdnyakov

A non-destructive technique for obtaining voltage contrast information with photoelectron emission microscopy (PEEM) is described. Samples consisting of electrically isolated metal lines were used to quantify voltage contrast in PEEM. The…

Materials Science · Physics 2009-05-04 Vinod K. Sangwan , Vincent W. Ballarotto , Karen Siegrist , Ellen D. Williams

Cell tracking is a key computational task in live-cell microscopy, but fully automated analysis of high-throughput imaging requires reliable and, thus, uncertainty-aware data analysis tools, as the amount of data recorded within a single…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Richard D. Paul , Johannes Seiffarth , David Rügamer , Hanno Scharr , Katharina Nöh

Fourier ptychographic microscopy (FPM) is a recently developed imaging modality that uses angularly varying illumination to extend a system performance beyond the limit defined by its optical elements. The FPM technique applies a novel…

Optics · Physics 2014-05-02 Xiaoze Ou , Roarke Horstmeyer , Changhuei Yang , Guoan Zheng

The automated segmentation of cells in microscopic images is an open research problem that has important implications for studies of the developmental and cancer processes based on in vitro models. In this paper, we present the approach for…

Computer Vision and Pattern Recognition · Computer Science 2018-01-03 Sholpan Kauanova , Ivan Vorobjev , Alex Pappachen James

Medical image segmentation plays an important role in clinical decision making, treatment planning, and disease tracking. However, it still faces two major challenges. On the one hand, there is often a ``soft boundary'' between foreground…

Image and Video Processing · Electrical Eng. & Systems 2024-12-12 Mengqi Lei , Haochen Wu , Xinhua Lv , Xin Wang