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Time-triggered and event-triggered control strategies for stabilization of an unstable plant over a rate-limited communication channel subject to unknown, bounded delay are studied and compared. Event triggering carries implicit…

Optimization and Control · Mathematics 2017-10-10 Mohammad Javad Khojasteh , Pavankumar Tallapragada , Jorge Cortes , Massimo Franceschetti

We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of…

Molecular Networks · Quantitative Biology 2015-11-12 Matteo Polettini , Artur Wachtel , Massimiliano Esposito

Linearized catalytic reaction equations modeling e.g. the dynamics of genetic regulatory networks under the constraint that expression levels, i.e. molecular concentrations of nucleic material are positive, exhibit nontrivial dynamical…

Disordered Systems and Neural Networks · Physics 2015-05-18 Rudolf Hanel , Manfred Pöchacker , Stefan Thurner

Micro- and nano-scale systems driven by rapid changes in control parameters (control protocols) dissipate significant energy. In the fast-protocol limit, we find that protocols that minimize dissipation at fixed duration are universally…

Statistical Mechanics · Physics 2021-08-11 Steven Blaber , Miranda D. Louwerse , David A. Sivak

A ubiquitous building block of signaling pathways is a cycle of covalent modification (e.g., phosphorylation and dephosphorylation in MAPK cascades). Our paper explores the kind of information processing and filtering that can be…

Molecular Networks · Quantitative Biology 2015-05-13 Carlos Gomez-Uribe , George C. Verghese , Leonid A. Mirny

Directional chemosensing is ubiquitous in cell biology, but some cells such as mating yeast paradoxically degrade the signal they aim to detect. While the data processing inequality suggests that such signal modification cannot increase the…

Biological Physics · Physics 2023-10-04 Ryan LeFebre , Joseph A. Landsittel , David E. Stone , Andrew Mugler

Near equilibrium, thermodynamic intuition suggests that fast, irreversible processes will dissipate more energy and entropy than slow, quasistatic processes connecting the same initial and final states. Here, we test the hypothesis that…

Statistical Mechanics · Physics 2022-12-07 Rebecca A. Bone , Daniel J. Sharpe , David J. Wales , Jason R. Green

Living cells use readout molecules to record the state of receptor proteins, similar to measurements or copies in typical computational devices. But is this analogy rigorous? Can cells be optimally efficient, and if not, why? We show that,…

Statistical Mechanics · Physics 2017-04-19 Thomas E. Ouldridge , Pieter Rein ten Wolde

Stochastic dynamics of chemical reactions in a mutually repressing two-gene circuit is numerically simulated. The circuit has a rich variety of different states when the kinetic change of DNA status is slow. The stochastic switching…

Disordered Systems and Neural Networks · Physics 2009-11-11 Tomohiro Ushikubo , Wataru Inoue , Mitsumasa Yoda , Masaki Sasai

Reducing work fluctuation and dissipation in heat engines or, more generally, information heat engines that perform feedback control is vital to maximize their efficiency. The same problem arises when we attempt to maximize the efficiency…

Statistical Mechanics · Physics 2016-01-06 Ken Funo , Masahito Ueda

Minimal models of active and driven particles have recently been used to elucidate many properties non-equilibrium systems. However, the relation between energy consumption and changes in the structure and transport properties of these…

Soft Condensed Matter · Physics 2017-08-03 Clara del Junco , Laura Tociu , Suriyanarayanan Vaikuntanathan

In many biological networks the responses of individual elements are ambiguous. We consider a scenario in which many sensors respond to a shared signal, each with limited information capacity, and ask that the outputs together convey as…

Biological Physics · Physics 2025-12-30 Marianne Bauer , William Bialek

Signaling is wasteful. But how wasteful? We study the fraction of surplus dissipated in a separating equilibrium. For isoelastic environments, this waste ratio has a simple formula: $\beta/(\beta+\sigma)$, where $\beta$ is the benefit…

General Economics · Economics 2026-04-17 Alex Frankel , Navin Kartik

We experimentally investigate the escape from a metastable state over a fluctuating barrier of a physical system. The system is switching between two states under electronic control of a dichotomous noise. We measure the escape time and its…

Statistical Mechanics · Physics 2009-10-31 Rosario N. Mantegna , Bernardo Spagnolo

Dissipative engineering constitutes a framework within which quantum information processing protocols are powered by system-environment interaction rather than by unitary dynamics alone. This framework embraces noise as a resource, and…

Quantum Physics · Physics 2015-06-05 M. J. Kastoryano , M. M. Wolf , J. Eisert

In equilibrium systems with short-ranged interactions, the relative stability of different thermodynamic states generally does not depend on system size (as long as this size is larger than the interaction range). Here, we use a large…

Statistical Mechanics · Physics 2013-05-30 Sorin Tanase-Nicola , David K. Lubensky

Dissipation is commonly regarded as an obstacle to quantum control, as it induces decoherence and irreversibility. Here we demonstrate that dissipation can instead be exploited as a resource to reshape the dynamics of interacting quantum…

Quantum Physics · Physics 2026-02-20 Debabrata Mondal , Lea F. Santos , S. Sinha

Chemically active droplets provide simple models for cell-like systems that can grow and divide. Such active droplet systems are driven away from thermodynamic equilibrium and turn over chemically, which corresponds to a simple metabolism.…

Biological Physics · Physics 2022-09-28 Jonathan Bauermann , Christoph A. Weber , Frank Jülicher

The excess work required to drive a stochastic system out of thermodynamic equilibrium through a time-dependent external perturbation is directly related to the amount of entropy produced during the driving process, allowing excess work and…

Statistical Mechanics · Physics 2021-03-15 Steven J Large , Jannik Ehrich , David A Sivak

This technical note considers the problem of resource allocation in linear feedback control system with output disturbance. By decomposing the information rate in the feedback communication channel, the channel resource allocation is…

Information Theory · Computer Science 2015-11-12 Xue Dong , Kun Wang , Chong Xu , Weimin Wang