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The development and progression of abdominal aortic aneurysms (AAA) are related to complex flow patterns and wall-shear-driven mechanobiological stimuli, yet the quantitative relationship between aneurysmal geometry and hemodynamics remains…

In this work we propose to validate the predictive capabilities of one-dimensional (1D) blood flow models with full three-dimensional (3D) models in the context of patient-specific coronary hemodynamics in hyperemic conditions. Such…

Left ventricular diastolic dysfunction (LVDD) is a group of diseases that adversely affect the passive phase of the cardiac cycle and can lead to heart failure. While left ventricular end-diastolic pressure (LVEDP) is a valuable prognostic…

Tissues and Organs · Quantitative Biology 2025-01-23 Emilio A. Mendiola , Raza Rana Mehdi , Dipan J. Shah , Reza Avazmohammadi

The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data…

Fluid Dynamics · Physics 2014-07-29 S. Fortini , G. Querzoli , S. Espa , A. Cenedese

- Modeling Human cardiovascular system is always an important issue. One of the most effective methods is using lumped model to reach to a complete model of human cardiovascular system. Such modeling with advanced considerations is used in…

Local hemodynamic forces play an important role in determining the functional significance of coronary arterial stenosis and understanding the mechanism of coronary disease progression. Computational fluid dynamics (CFD) have been widely…

Computer Vision and Pattern Recognition · Computer Science 2023-05-31 Ziyu Ni , Linda Wei , Lijian Xu , Simon Yu , Qing Xia , Hongsheng Li , Shaoting Zhang

Cerebral aneurysms are pathological dilations of intracranial arteries that can rupture with devastating consequences, including subarachnoid hemorrhage, stroke, and death. Accumulating evidence indicates that local hemodynamic forces play…

Other Quantitative Biology · Quantitative Biology 2025-05-22 Reza Bozorgpour , Pilwan Kim

Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac…

Medical Physics · Physics 2014-06-25 Saeed Ranjbar , Mersedeh Karvandi

Three-dimensional (3D) cardiovascular fluid dynamics simulations typically require hours to days of computing time on a high-performance computing cluster. One-dimensional (1D) and lumped-parameter zero-dimensional (0D) models show great…

Computational Engineering, Finance, and Science · Computer Science 2022-08-12 Martin R. Pfaller , Jonathan Pham , Aekaansh Verma , Luca Pegolotti , Nathan M. Wilson , David W. Parker , Weiguang Yang , Alison L. Marsden

Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…

Machine Learning · Computer Science 2019-09-19 Georgios Kissas , Yibo Yang , Eileen Hwuang , Walter R. Witschey , John A. Detre , Paris Perdikaris

Cardiac left ventricle (LV) quantification provides a tool for diagnosing cardiac diseases. Automatic calculation of all relevant LV indices from cardiac MR images is an intricate task due to large variations among patients and deformation…

Image and Video Processing · Electrical Eng. & Systems 2020-02-04 Nils Gessert , Alexander Schlaefer

Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional…

Computational fluid dynamics (CFD) is a valuable tool for personalised, non-invasive evaluation of hemodynamics in arteries, but its complexity and time-consuming nature prohibit large-scale use in practice. Recently, the use of deep…

Machine Learning · Computer Science 2022-01-21 Julian Suk , Pim de Haan , Phillip Lippe , Christoph Brune , Jelmer M. Wolterink

Computational fluid dynamics (CFD) simulation provides valuable information on blood flow from the vascular geometry. However, it requires extracting precise models of arteries from low-resolution medical images, which remains challenging.…

Computational Geometry · Computer Science 2023-06-14 Méghane Decroocq , Carole Frindel , Pierre Rougé , Makoto Ohta , Guillaume Lavoué

Computer modeling of the cardiovascular system has potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles…

Tissues and Organs · Quantitative Biology 2026-02-05 Mitchel J. Colebank , Alfonso Limon , Anthony Chang , Brandon Wong , Wyman Lai , Hamilton Baker

Flow of cerebrospinal fluid in perivascular spaces is a key mechanism underlying brain transport and clearance. In this paper, we present a mathematical and numerical formalism for reduced models of pulsatile viscous fluid flow in networks…

Fluid Dynamics · Physics 2021-11-25 Cécile Daversin-Catty , Ingeborg G. Gjerde , Marie E. Rognes

This study investigates the effects of geometric model reduction on blood flow simulations in the patient-specific descending aorta, followed by speed-accuracy trade-off analysis using 3D simulations. We demonstrate how wall shear stresses…

Fluid Dynamics · Physics 2025-12-12 Rishi Kumar , K. Muralidhar , Indranil Saha Dalal

Automatic detection and classification of Cardiovascular disease (CVD) from Computed Tomography (CT) images play an important part in facilitating better-informed clinical decisions. However, most of the recent deep learning based methods…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Ajay Mittal , Raghav Mehta , Omar Todd , Philipp Seeböck , Georg Langs , Ben Glocker

Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of…

Pattern Formation and Solitons · Physics 2007-05-23 T. K. Shajahan , Sitabhra Sinha , Rahul Pandit

An accurate assessment of the cardiovascular system and prediction of cardiovascular diseases (CVDs) are crucial. Measured cardiac blood flow data provide insights about patient-specific hemodynamics, where many specialized techniques have…

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