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We present and critically discuss five commonly used mathematical models of the meal glucose rate of appearance in humans. Such models are key to simulation of the metabolism in healthy people, people with diabetes, and obese people, and…

Systems and Control · Electrical Eng. & Systems 2023-08-01 Tobias K. S. Ritschel , Asbjørn Thode Reenberg , Peter Emil Carstensen , Jacob Bendsen , John Bagterp Jørgensen

Type 1 Diabetes (T1D) is an autoimmune disease leading to insulin insufficiency. Thus, patients require lifelong insulin therapy, which has a side effect of hypoglycemia. Hypoglycemia is a critical state of decreased blood glucose levels…

Machine Learning · Computer Science 2026-01-21 Beyza Cinar , Louisa van den Boom , Maria Maleshkova

While the Artificial Pancreas is effective in regulating the blood glucose in the safe range of 70-180 mg/dl in type 1 diabetic patients, the high intra-patient variability, as well as exogenous meal disturbances, poses a serious challenge.…

Systems and Control · Electrical Eng. & Systems 2022-06-30 Bhabani Shankar Dey , Anirudh Nath , Abhilash Patel , Indra Narayan Kar

People with diabetes have to manage their blood glucose level to keep it within an appropriate range. Predicting whether future glucose values will be outside the healthy threshold is of vital importance in order to take corrective actions…

Machine Learning · Computer Science 2023-04-03 J. Alvarado , J. Manuel Velasco , F. Chávez , J. Ignacio Hidalgo , F. Fernández de Vega

The challenge of handling missing data is widespread in modern data analysis, particularly during the preprocessing phase and in various inferential modeling tasks. Although numerous algorithms exist for imputing missing data, the…

Methodology · Statistics 2024-03-28 Marcos Matabuena , Carla Díaz-Louzao , Rahul Ghosal , Francisco Gude

Effective diabetes management relies heavily on the continuous monitoring of blood glucose levels, traditionally achieved through invasive and uncomfortable methods. While various non-invasive techniques have been explored, such as optical,…

Machine Learning · Computer Science 2024-08-16 Nihat Ahmadli , Mehmet Ali Sarsil , Onur Ergen

Diabetes mellitus is a common disease of human body caused by a group of metabolic disorders where the sugar levels over a prolonged period is very high. It affects different organs of the human body which thus harm a large number of the…

Machine Learning · Computer Science 2019-02-27 Md. Faisal Faruque , Asaduzzaman , Iqbal H. Sarker

The conventional method of glucose measurement such as pricking blood from the body is prevalent which brings pain and trauma. Invasive methods of measurement sometimes raise the risk of blood infection to the patient. Sometimes, some of…

Medical Physics · Physics 2023-08-24 Prateek Jain , Amit Joshi , Saraju Mohanty

This study introduces a novel approach for early Type 2 Diabetes Mellitus (T2DM) risk prediction using a tabular transformer (TabTrans) architecture to analyze longitudinal patient data. By processing patients` longitudinal health records…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Sulaiman Khan , Md. Rafiul Biswas , Zubair Shah

Background: Predictive modeling is a key component of solutions to many healthcare problems. Among all predictive modeling approaches, machine learning methods often achieve the highest prediction accuracy, but suffer from a long-standing…

Machine Learning · Computer Science 2018-12-10 Gang Luo

Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain…

Tissues and Organs · Quantitative Biology 2014-03-05 S. M. Kissler , C. Cichowitz , S. Sankaranarayanan , D. M. Bortz

Diabetes is one of the deadliest diseases in the world and affects nearly 10 percent of the global adult population. Fortunately, powerful new technologies allow for a consistent and reliable treatment plan for people with diabetes. One…

Other Quantitative Biology · Quantitative Biology 2021-01-08 Julia Ann Jose , Trae Waggoner , Sudarsan Manikandan

Insulin resistance, a precursor to type 2 diabetes, is characterized by impaired insulin action in tissues. Current methods for measuring insulin resistance, while effective, are expensive, inaccessible, not widely available and hinder…

Diabetes mellitus is a complex group of syndromes that have in common a disturbance in the body's use of glucose, resulting in an elevated blood sugar. Once detected, sugar diabetes can be controlled by an appropriate regimen that should…

Medical Physics · Physics 2008-11-03 Raju Poddar , Joseph Thomas Andrews , Pratyoosh Shukla , Pratima Sen

We consider the question of 30-minute prediction of blood glucose levels measured by continuous glucose monitoring devices, using clinical data. While most studies of this nature deal with one patient at a time, we take a certain percentage…

Machine Learning · Computer Science 2017-07-20 H. N. Mhaskar , S. V. Pereverzyev , M. D. van der Walt

Accurately estimating parameters of physiological models is essential to achieving reliable digital twins. For Type 1 Diabetes, this is particularly challenging due to the complexity of glucose-insulin interactions. Traditional methods…

The increasing number of diabetic patients is a serious issue in society today, which has significant negative impacts on people's health and the country's financial expenditures. Because diabetes may develop into potential serious…

Artificial Intelligence · Computer Science 2024-04-18 Ziyi Zhou , Ming Cheng , Yanjun Cui , Xingjian Diao , Zhaorui Ma

Artificial intelligence (AI) algorithms are a critical part of state-of-the-art digital health technology for diabetes management. Yet, access to large high-quality datasets is creating barriers that impede development of robust AI…

Artificial Intelligence · Computer Science 2025-07-21 Temiloluwa Prioleau , Baiying Lu , Yanjun Cui

Background and objective: Hybrid automated insulin delivery (hAID) systems represent the most advanced therapy for type 1 diabetes (T1D). Current systems rely on linear or linearized models of glucose homeostasis, which may compromise…

Systems and Control · Electrical Eng. & Systems 2025-12-08 Vihangkumar V. Naik , Eleonora Manzoni , Clara Escorihuela-Altaba , Jose Garcia-Tirado

Research in diabetes, especially when it comes to building data-driven models to forecast future glucose values, is hindered by the sensitive nature of the data. Because researchers do not share the same data between studies, progress is…

Quantitative Methods · Quantitative Biology 2020-09-10 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi
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