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Estimating local false discovery rates (fdr) is central to large-scale multiple hypothesis testing, yet different methods often produce divergent results, and there is little guidance for selecting among them. Because ground truth…

Methodology · Statistics 2025-09-17 Jenna M. Landy , Giovanni Parmigiani

Neural network (NN) ensembles can reduce large prediction variance of NN and improve prediction accuracy. For highly nonlinear problems with insufficient data set, the prediction accuracy of NN models becomes unstable, resulting in a…

Machine Learning · Computer Science 2022-10-20 Ungki Lee , Namwoo Kang

Building upon the mean p-power error (MPE) criterion, the normalized subband p-norm (NSPN) algorithm demonstrates superior robustness in $\alpha$-stable noise environments ($1 < \alpha \leq 2$) through effective utilization of low-order…

Signal Processing · Electrical Eng. & Systems 2026-01-16 Jianhong Ye , Haiquan Zhao , Yi Peng

Non-coding RNA structure and function are essential to understanding various biological processes, such as cell signaling, gene expression, and post-transcriptional regulations. These are all among the core problems in the RNA field. With…

Quantitative Methods · Quantitative Biology 2022-08-09 Jiayang Chen , Zhihang Hu , Siqi Sun , Qingxiong Tan , Yixuan Wang , Qinze Yu , Licheng Zong , Liang Hong , Jin Xiao , Tao Shen , Irwin King , Yu Li

Feature selection is a preprocessing step which plays a crucial role in the domain of machine learning and data mining. Feature selection methods have been shown to be effctive in removing redundant and irrelevant features, improving the…

Machine Learning · Computer Science 2021-06-01 Xiongshi Deng , Min Li , Lei Wang , Qikang Wan

People can innately recognize human facial expressions in unnatural forms, such as when depicted on the unusual faces drawn in cartoons or when applied to an animal's features. However, current machine learning algorithms struggle with…

Computer Vision and Pattern Recognition · Computer Science 2023-04-06 Michael Stettler , Alexander Lappe , Nick Taubert , Martin Giese

Motivation: The mapping of RNA-seq reads to their transcripts of origin is a fundamental task in transcript expression estimation and differential expression scoring. Where ambiguities in mapping exist due to transcripts sharing sequence,…

Genomics · Quantitative Biology 2015-01-28 James Hensman , Peter Glaus , Antti Honkela , Magnus Rattray

RNA sequencing (RNA-seq) has been rapidly adopted for the profiling of transcriptomes in many areas of biology, including studies into gene regulation, development and disease. Of particular interest is the discovery of differentially…

Convolutional recurrent networks (CRN) integrating a convolutional encoder-decoder (CED) structure and a recurrent structure have achieved promising performance for monaural speech enhancement. However, feature representation across…

Sound · Computer Science 2024-12-02 Shengkui Zhao , Bin Ma , Karn N. Watcharasupat , Woon-Seng Gan

In just the last decade, a multitude of bio-technologies and software pipelines have emerged to revolutionize genomics. To further their central goal, they aim to accelerate and improve the quality of de novo whole-genome assembly starting…

Genomics · Quantitative Biology 2015-06-11 Francesco Vezzi , Giuseppe Narzisi , Bud Mishra

Motivation :Reconstructing the topology of a gene regulatory network is one of the key tasks in systems biology. Despite of the wide variety of proposed methods, very little work has been dedicated to the assessment of their stability…

Molecular Networks · Quantitative Biology 2012-08-20 Marco Grimaldi , Giuseppe Jurman , Roberto Visintainer

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

The investigation of plant transcriptional regulation constitutes a fundamental basis for crop breeding, where cis-regulatory elements (CREs), as the key factor determining gene expression, have become the focus of crop genetic improvement…

Genomics · Quantitative Biology 2025-05-16 Yingjun Wu , Jingyun Huang , Liang Ming , Pengcheng Deng , Maojun Wang , Zeyu Zhang

Focal plane wavefront sensing (FPWFS) is appealing for several reasons. Notably, it offers high sensitivity and does not suffer from non-common path aberrations (NCPA). The price to pay is a high computational burden and the need for…

Instrumentation and Methods for Astrophysics · Physics 2021-07-14 G. Orban de Xivry , M. Quesnel , P. -O. Vanberg , O. Absil , G. Louppe

Graph Neural Networks (GNNs) have emerged as a powerful category of learning architecture for handling graph-structured data. However, existing GNNs typically ignore crucial structural characteristics in node-induced subgraphs, which thus…

Machine Learning · Computer Science 2023-06-13 Kaixuan Chen , Shunyu Liu , Tongtian Zhu , Tongya Zheng , Haofei Zhang , Zunlei Feng , Jingwen Ye , Mingli Song

This study evaluates the concordance between RNA sequencing (RNA-Seq) and NanoString technologies for gene expression analysis in non-human primates (NHPs) infected with Ebola virus (EBOV). We performed a detailed comparison of both…

Genomics · Quantitative Biology 2024-11-01 Mostafa Rezapour , Aarthi Narayanan , Wyatt H. Mowery , Metin Nafi Gurcan

Exponential random graph models (ERGMs) are flexible probabilistic frameworks to model statistical networks through a variety of network summary statistics. Conventional Bayesian estimation for ERGMs involves iteratively exchanging with an…

Methodology · Statistics 2025-04-15 Yefeng Fan , Simon White

Auto-regressive neural sequence models have been shown to be effective across text generation tasks. However, their left-to-right decoding order prevents generation from being parallelized. Insertion Transformer (Stern et al., 2019) is an…

Computation and Language · Computer Science 2023-02-01 Zhisong Zhang , Yizhe Zhang , Bill Dolan

Recently the sparse representation based classification (SRC) has been proposed for robust face recognition (FR). In SRC, the testing image is coded as a sparse linear combination of the training samples, and the representation fidelity is…

Computer Vision and Pattern Recognition · Computer Science 2015-06-04 Meng Yang , Lei Zhang , Jian Yang , David Zhang

Functional or non-coding RNAs are attracting more attention as they are now potentially considered valuable resources in the development of new drugs intended to cure several human diseases. The identification of drugs targeting the…

Genomics · Quantitative Biology 2019-12-25 Muhammad Nabeel Asima , Muhammad Imran Malik , Andreas Dengela , Sheraz Ahmed