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Scientific feasibility assessment asks whether a claim is consistent with established knowledge and whether experimental evidence could support or refute it. We frame feasibility assessment as a diagnostic reasoning task in which, given a…

Computation and Language · Computer Science 2026-04-22 Seyedali Mohammadi , Manas Gaur , Francis Ferraro

A fundamental challenge in causal inference with observational data is correct specification of a causal model. When there is model uncertainty, analysts may seek to use estimates from multiple candidate models that rely on distinct, and…

Methodology · Statistics 2026-03-03 Rohit Bhattacharya , Ina Ocelli , Ted Westling

We pose the following question: If a physical experiment were to be completely controlled by an algorithm, what effect would the algorithm have on the physical measurements made possible by the experiment? In a programme to study the nature…

Logic · Mathematics 2009-11-20 E. J. Beggs , J. F. Costa , J. V. Tucker

The goal of this article is to give an overview of the current limitations and epistemological barriers in Science and Scientific Philosophy from a very general point of view. We first list and define the types of knowledge nous, doxa and…

History and Philosophy of Physics · Physics 2023-12-29 J. E. Horvath , R. R. Fernandes , T. P. Idiart

The physics of matter in the condensed state is concerned with problems in which the number of constituent particles is vastly greater than can be easily comprehended. The inherent physical limitations of the human mind are fundamental and…

History and Philosophy of Physics · Physics 2016-04-26 S. J. Blundell

The crisis in the reproducibility of experiments invites a re-evaluation of methods of inquiry and validation procedures. The text challenges current assumptions of knowledge acquisition and introduces G-complexity for defining decidable…

Other Quantitative Biology · Quantitative Biology 2016-12-09 Mihai Nadin

Results of measurements give legitimacy to a physical theory. What if acquiring these results in the first place necessitates what the same theory considers to be an interaction? In this note, we assume that theories account for…

Quantum Physics · Physics 2019-05-01 Arne Hansen , Stefan Wolf

The process of doing Science in condition of uncertainty is illustrated with a toy experiment in which the inferential and the forecasting aspects are both present. The fundamental aspects of probabilistic reasoning, also relevant in real…

History and Overview · Mathematics 2018-02-07 Giulio D'Agostini

In physics the value of a theory is measured by its agreement with experimental data. But how should the physics community gauge the value of an emerging theory that has not been tested experimentally as of yet? With no reality check, a…

Instrumentation and Methods for Astrophysics · Physics 2011-08-29 Abraham Loeb

The process of discovery in the physical, biological and medical sciences can be painstakingly slow. Most experiments fail, and the time from initiation of research until a new advance reaches commercial production can span 20 years. This…

Machine Learning · Computer Science 2020-04-15 Kristopher Reyes , Warren B Powell

Measurements play a crucial role in doing physics: Their results provide the basis on which we adopt or reject physical theories. In this note, we examine the effect of subjecting measurements themselves to our experience. We require that…

Quantum Physics · Physics 2020-01-28 Arne Hansen , Stefan Wolf

We propose a rigorous decomposition of predictive error, highlighting that not all 'irreducible' error is genuinely immutable. Many domains stand to benefit from iterative enhancements in measurement, construct validity, and modeling. Our…

Machine Learning · Computer Science 2025-02-12 Jiani Yan , Charles Rahal

A colloquial interpretation of entropy is that it is the knowledge gained upon learning the outcome of a random experiment. Conditional entropy is then interpreted as the knowledge gained upon learning the outcome of one random experiment…

Quantum Physics · Physics 2024-11-20 Gilad Gour , Mark M. Wilde , Sarah Brandsen , Isabelle Jianing Geng

The currently dominating artificial intelligence and machine learning technology, neural networks, builds on inductive statistical learning. Neural networks of today are information processing systems void of understanding and reasoning…

Artificial Intelligence · Computer Science 2022-08-26 Lars Holmberg

We warn against a common but incomplete understanding of empirical research in machine learning that leads to non-replicable results, makes findings unreliable, and threatens to undermine progress in the field. To overcome this alarming…

Experiments deliver credible treatment-effect estimates but, because they are costly, are often restricted to specific sites, small populations, or particular mechanisms. A common practice across several fields is therefore to combine…

Econometrics · Economics 2025-12-30 Aristotelis Epanomeritakis , Davide Viviano

We propose a measurement framework for difficult-to-access contexts that uses indirect data traces, interpretable machine-learning models, and theory-guided triangulation to fill inaccessible measurement spaces. Many high-stakes systems of…

Machine Learning · Computer Science 2026-02-03 Margaret Foster

One purpose -- quite a few thinkers would say the main purpose -- of seeking knowledge about the world is to enhance our ability to make good decisions. An item of knowledge that can make no conceivable difference with regard to anything we…

Artificial Intelligence · Computer Science 2013-04-12 Henry E. Kyburg

Cosmology has come a long way from being based on a small number of observations to being a data-driven precision science. We discuss the questions "What is observable?", "What in the Universe is knowable?" and "What are the fundamental…

Cosmology and Nongalactic Astrophysics · Physics 2016-07-28 Florent Leclercq , Alice Pisani , Benjamin D. Wandelt

This paper introduces Reflective Empiricism, an extension of empirical science that incorporates subjective perception and consciousness processes as equally valid sources of knowledge. It views reality as an interplay of subjective…

Physics and Society · Physics 2025-04-18 Oliver Marc Wittwer