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Biological data mainly comprises of Deoxyribonucleic acid (DNA) and protein sequences. These are the biomolecules which are present in all cells of human beings. Due to the self-replicating property of DNA, it is a key constitute of genetic…

Other Quantitative Biology · Quantitative Biology 2020-06-04 Shakeela Bibi , Javed Iqbal , Adnan Iftekhar , Mir Hassan

PhyloFrame is a Python library for phylogenetic computation targeting the gap between specialist, compiler-optimized operations and flexible, script-based workflows -- with emphasis on fast, memory-efficient operations for very large tree…

Populations and Evolution · Quantitative Biology 2026-05-28 Matthew Andres Moreno , Jeet Sukumaran , Luis Zaman , Emily Dolson

While the language modeling objective has been shown to be deeply connected with compression, it is surprising that modern LLMs are not employed in practical text compression systems. In this paper, we provide an in-depth analysis of neural…

Computation and Language · Computer Science 2024-09-26 Fazal Mittu , Yihuan Bu , Akshat Gupta , Ashok Devireddy , Alp Eren Ozdarendeli , Anant Singh , Gopala Anumanchipalli

Phylogenetic trees represent certain species and their likely ancestors. In such a tree, present-day species are leaves and an edge from u to v indicates that u is an ancestor of v. Weights on these edges indicate the phylogenetic distance.…

Populations and Evolution · Quantitative Biology 2025-10-08 Jannik Schestag

Technology progress in DNA sequencing boosts the genomic database growth at faster and faster rate. Compression, accompanied with random access capabilities, is the key to maintain those huge amounts of data. In this paper we present an…

Computational Engineering, Finance, and Science · Computer Science 2011-03-14 Szymon Grabowski , Sebastian Deorowicz

We propose a reinforcement-learning algorithm to tackle the challenge of reconstructing phylogenetic trees. The search for the tree that best describes the data is algorithmically challenging, thus all current algorithms for phylogeny…

Populations and Evolution · Quantitative Biology 2023-03-14 Dana Azouri , Oz Granit , Michael Alburquerque , Yishay Mansour , Tal Pupko , Itay Mayrose

Data compression continues to evolve, with traditional information theory methods being widely used for compressing text, images, and videos. Recently, there has been growing interest in leveraging Generative AI for predictive compression…

Information Theory · Computer Science 2024-09-24 Swathi Shree Narashiman , Nitin Chandrachoodan

The Fenwick tree is a classical implicit data structure that stores an array in such a way that modifying an element, accessing an element, computing a prefix sum and performing a predecessor search on prefix sums all take logarithmic time.…

Data Structures and Algorithms · Computer Science 2019-10-15 Stefano Marchini , Sebastiano Vigna

Phylogenetic trees are widely used to understand the evolutionary history of organisms. Tree shapes provide information about macroevolutionary processes. However, macroevolutionary models are unreliable for inferring the true processes…

Populations and Evolution · Quantitative Biology 2021-10-11 Albert Ch. Soewongsono , Barbara R. Holland , Małgorzata M. O'Reilly

In Image Compression, the researchers' aim is to reduce the number of bits required to represent an image by removing the spatial and spectral redundancies. Recently discrete wavelet transform and wavelet packet has emerged as popular…

Computer Vision and Pattern Recognition · Computer Science 2010-04-20 G. K. Kharate , V. H. Patil

The evolutionary relationships between species are typically represented in the biological literature by rooted phylogenetic trees. However, a tree fails to capture ancestral reticulate processes, such as the formation of hybrid species or…

Populations and Evolution · Quantitative Biology 2024-12-09 Johanna Heiss , Daniel H. Huson , Mike Steel

The method of flexi-Weighted Least Squares on evolutionary trees uses simple polynomial or exponential functions of the evolutionary distance in place of model-based variances. This has the advantage that unexpected deviations from…

Populations and Evolution · Quantitative Biology 2010-12-30 Peter J. Waddell , Xi Tan , Ishita Khan

Phylogenetic trees are the fundamental mathematical representation of evolutionary processes in biology. They are also objects of interest in pure mathematics, such as algebraic geometry and combinatorics, due to their discrete geometry.…

Metric Geometry · Mathematics 2022-07-01 Anthea Monod , Bo Lin , Ruriko Yoshida , Qiwen Kang

Relative Lempel-Ziv (RLZ) is a popular algorithm for compressing databases of genomes from individuals of the same species when fast random access is desired. With Kuruppu et al.'s (SPIRE 2010) original implementation, a reference genome is…

Data Structures and Algorithms · Computer Science 2016-05-17 Anthony J. Cox , Andrea Farruggia , Travis Gagie , Simon J. Puglisi , Jouni Sirén

The search for similarity and dissimilarity measures on phylogenetic trees has been motivated by the computation of consensus trees, the search by similarity in phylogenetic databases, and the assessment of clustering results in…

Populations and Evolution · Quantitative Biology 2011-11-09 Francesc Rossello , Gabriel Valiente

Phylogenetics is the study of the evolutionary relationships between organisms. One of the main challenges in the field is to take biological data for a group of organisms and to infer an evolutionary tree, a graph that represents these…

Populations and Evolution · Quantitative Biology 2019-06-05 Elizabeth Gross , Colby Long , Joseph Rusinko

A phylogenetic tree is a way to organize a finite set of species, individuals or other sources of related data. The species for which we have existing DNA data make up the set of leaves of the tree. The balanced minimal evolution method of…

Combinatorics · Mathematics 2016-08-05 Stefan Forcey , Logan Keefe , William Sands

Background: The reconstruction of the phylogenetic tree topology of four taxa is, still nowadays, one of the main challenges in phylogenetics. Its difficulties lie in considering not too restrictive evolutionary models, and correctly…

Populations and Evolution · Quantitative Biology 2014-06-19 Esther Ibáñez , Marta Casanellas

The reconstruction of phylogenies from DNA or protein sequences is a major task of computational evolutionary biology. Common phenomena, notably variations in mutation rates across genomes and incongruences between gene lineage histories,…

Probability · Mathematics 2012-11-30 Elchanan Mossel , Sebastien Roch

A phylogenetic tree is a graphical representation of an evolutionary history of taxa in which the leaves correspond to the taxa and the non-leaves correspond to speciations. One of important problems in phylogenetic analysis is to assemble…

Combinatorics · Mathematics 2022-02-25 Hiroshi Hirai , Yuni Iwamasa
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