Phylogenetic mixtures: Concentration of measure in the large-tree limit
Abstract
The reconstruction of phylogenies from DNA or protein sequences is a major task of computational evolutionary biology. Common phenomena, notably variations in mutation rates across genomes and incongruences between gene lineage histories, often make it necessary to model molecular data as originating from a mixture of phylogenies. Such mixed models play an increasingly important role in practice. Using concentration of measure techniques, we show that mixtures of large trees are typically identifiable. We also derive sequence-length requirements for high-probability reconstruction.
Keywords
Cite
@article{arxiv.1108.3112,
title = {Phylogenetic mixtures: Concentration of measure in the large-tree limit},
author = {Elchanan Mossel and Sebastien Roch},
journal= {arXiv preprint arXiv:1108.3112},
year = {2012}
}
Comments
Published in at http://dx.doi.org/10.1214/11-AAP837 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)