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The fluorescence microscope is one of the most important tools in modern clinical diagnosis and biological science. However, its expense, size and limited field-of-view (FOV) are becoming bottlenecks in key applications such as large-scale…
Visual field tests (VFT) are pivotal for glaucoma diagnosis and conducted regularly to monitor disease progression. Here we address the question to what degree aggregate VFT measurements such as Visual Field Index (VFI) and Mean Deviation…
Ptychographic Coherent Diffractive Imaging enables diffraction-limited imaging of nanoscale structures at extreme ultraviolet and x-ray wavelengths, where high-quality image-forming optics are not available. However, its reliance on a set…
Optical tweezers (OTs) with structured light expand degrees of freedom of particle manipulation. However, the studies of structured optical tweezers are usually accompanied by complex theoretical models, strict simulation conditions, and…
Evanescent-wave microscopy achieves sub-diffraction axial sectioning by confining fluorescence excitation to a thin layer close to the cell/substrate interface. How thin this light sheet exactly is, however, is often unknown. Particularly…
Optical diffraction tomography (ODT) has emerged as a powerful label-free three-dimensional (3D) bioimaging techniques for observing living cells and thin tissue layers. We report a new reflection-mode ODT (rODT) method for imaging thick…
We study the angular deflection of the circular polarized components of a linearly polarized probe field in a weakly birefringent atomic system in tripod configuration. A spatially inhomogeneous control field incident obliquely onto an…
Structured light beams carrying orbital angular momentum (OAM), such as Laguerre-Gaussian modes, are promising tools for high-capacity optical communications and advanced biomedical imaging. However, multiple scattering in turbid media…
Future large space telescopes will be equipped with adaptive optics (AO) to overcome wavefront aberrations and achieve high contrast for imaging faint astronomical objects, such as earth-like exoplanets and debris disks. In contrast to AO…
While optical coherence tomography (OCT) provides a resolution down to 1 micrometer it has difficulties to visualize cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast…
We present a dynamic interferometry to measure the orbital angular momentum (OAM) of beams. An opaque screen with two air slits is employed, which can be regarded as the Youngs double-pinhole interference. When the OAM beams with an annular…
We report a surprising observation that the output directionality from wavelength-scale optical microcavities displays extreme sensitivity to deformations of the cavity shape. A variation of the cavity boundary on the order of ten…
Mid-infrared light scatters much less than shorter wavelengths, allowing greatly enhanced penetration depths for optical imaging techniques such as optical coherence tomography (OCT). However, both detection and broadband sources in the…
A rigorous approach for solving canonical circular open-ended dielectric-lined waveguide diffraction problems is presented. This is continuation of our recent paper [1] where a simpler case of uniform dielectric filling has been considered.…
t is a known fact that near field diffraction or Fresnel diffraction calculations are difficult to perform exactly. It is in general necessary to make some approximations in order to obtain a more suitable form. In this work, a numerical…
A wave near an isolated turning point is typically assumed to have an Airy function profile with respect to the separation distance. This description is incomplete, however, and is insufficient to describe the behavior of more realistic…
Lensless imaging enables exceptionally compact fluorescence sensors, advancing applications in \textit{in vivo} imaging and low-cost, point-of-care diagnostics. These sensors require a filter to block the excitation light while passing…
A prospective study was performed on neurosurgical samples from 18 patients to evaluate the use of Full-Field Optical Coherence Tomography (FF-OCT) in brain tumor diagnosis. FF-OCT captures en face slices of tissue samples at 1\mum…
Diffraction limit is manifested in the loss of high spatial frequency information that results from decay of evanescent waves. As a result, conventional far-field optics yields no information about an object's subwavelength features. Here…
We present a practical apparatus for characterizing optical aberrations of large collimation mirrors and lenses, and give a detailed analysis of wavefront-detection errors. We utilize a scanning pentaprism technique for precise measurements…