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Ultrasound contrast agents comprise gas microbubbles surrounded by stabilising elastic or viscoelastic shells. Microbubbles containing liquid or solid cores are referred to as antibubbles. The manufacturing process of long-lived antibubbles…

The scattering of ultrasound from bubbles of micrometer-sized radius, such as used in contrast enhancers for ultrasound diagnostics, is studied. We show that sound scattering and ``active'' emission of sound from oscillating bubbles are not…

Soft Condensed Matter · Physics 2009-10-31 Sascha Hilgenfeldt , Detlef Lohse , Michael Zomack

Ultrasound contrast agents have been recently utilized in therapeutical implementations for targeted delivery of pharmaceutical substances. Radial pulsations of the encapsulated microbubbles under the action of an ultrasound field are…

Soft Condensed Matter · Physics 2018-11-29 Farzan Ghalichi , Sohrab Behnia , Farshad Mottaghi , Mohammad Yahyavi

Microbubbles - used as contrast agents in ultrasound imaging - are important tools in biomedical research, having been used together with ultrasound to develop significant diagnostic and therapeutic techniques. It has been suggested that…

Medical Physics · Physics 2022-11-23 Prashant Pandey

Ultrasound offers promising applications in biology and chemistry, but quantifying local ultrasound conditions remains challenging due to the lack of non-invasive measurement tools. We introduce antibubbles as novel optical reporters of…

The benefits of ultrasound are its ease-of-use and its ability to precisely deliver energy in opaque and complex media. However, most materials responsive to ultrasound show a weak response, requiring the use of high powers, which are…

Soft Condensed Matter · Physics 2023-08-01 Nicolas Moreno-Gomez , Athanasios G. Athanassiadis , Albert T. Poortinga , Peer Fischer

Ultrasound contrast imaging is a specialized imaging technique that applies microbubble contrast agents to traditional medical sonography, providing real-time visualization of blood flow and vessels. Gas-filled microbubbles are injected…

Analysis of PDEs · Mathematics 2024-12-17 Vanja Nikolić , Teresa Rauscher

Contrast microbubbles (contrast agents) were initially developed to increase the contrast of the image in ultrasound imaging. These microbubbles consist of a gas core encapsulated by a layer of protein or lipid to stabilize them against…

Medical Physics · Physics 2018-02-26 Nima Mobadersany , Kausik Sarkar

Microbubbles, either in the form of free gas bubbles surrounded by a fluid or encapsulated bubbles used currently as contrast agents for medical echography, exhibit complex dynamics under specific acoustic excitations. Nonetheless,…

Pattern Formation and Solitons · Physics 2023-05-09 Jennifer Chaline , Noé Jiménez , Ahmed Mehrem , Ayache Bouakaz , Serge Dos Santos , Víctor J. Sánchez-Morcillo

Ultrasound-driven microbubbles rectify oscillatory motion into strong steady streaming flow [1, 2]. In this fluid dynamics video, we show size-dependent trapping, focusing and sorting of microparticles, utilizing the interaction between…

Fluid Dynamics · Physics 2010-10-19 Cheng Wang , Shreyas Jalikop , Sascha Hilgenfeldt

Manipulation of micro/nano particles has been well studied and demonstrated by optical, electromagnetic, and acoustic approaches, or their combinations. Manipulation of internal structure of droplet/particle is rarely explored and remains…

Ultrasonic irradiation of liquids, such as water-alcohol solutions, results in cavitation or the formation of small bubbles. Cavitation bubbles are generated in real solutions without the use of optical traps making our system as close to…

Acoustic droplet vaporization denotes the phase-change of micron- and sub-micron-sized droplets upon the application of high-amplitude ultrasound. The asymmetric collapse of the incepted vapor bubbles within the droplets can give rise to…

Fluid Dynamics · Physics 2026-05-11 Anunay Prasanna , Samuele Fiorini , Gazendra Shakya , Outi Supponen

Understanding the shell rheology of ultrasound contrast agent microbubbles is vital for anticipating their bioeffects in clinical practice. Past studies using sophisticated acoustic and optical techniques have made enormous progress in this…

Fluid Dynamics · Physics 2023-08-14 Marco Cattaneo , Outi Supponen

We present an analytical model for the frequency response of a gas microbubble oscillating near a spherical inclusion of arbitrary size and mechanical nature (rigid, fluid, or viscoelastic) immersed in a viscous compressible fluid. The…

Fluid Dynamics · Physics 2025-12-22 Thomas Micol , Alexander A. Doinikov , Cyril Mauger , Claude Inserra

The inherent instability of oscillatory flows presents a significant challenge in microfluidics, impairing performance in different applications from particle detachemnt to organs-on-a-chip. Trapped air inside a microfluidic system…

Fluid Dynamics · Physics 2025-11-04 Andreu Benavent-Claró

Focused ultrasound stimulated microbubbles have been shown to be capable of inducing blood flow shutdown and necrosis in a range of tissue types in an approach termed antivascular ultrasound or mechanical ablation. In oncology, this…

Medical Physics · Physics 2022-10-17 Xiaoxiao Zhao , Carly Pellow , David E. Goertz

We present experimental investigations of antibubbles. Such an unusual fluid object is a thin spherical air shell surrounding a liquid globule. We explain how to produce them and we study their stability. By overweighting antibubbles with a…

Soft Condensed Matter · Physics 2007-05-23 S. Dorbolo , N. Vandewalle

Understanding the ultrasound pressure-driven dynamics of microbubbles confined in viscoelastic materials is relevant for multiple biomedical applications, ranging from contrast-enhanced ultrasound imaging to ultrasound-assisted drug…

The influence of initial shape imperfections on the post-buckling and translational behavior of encapsulated microbubbles is investigated subject to acoustic excitation in an unbounded flow. Bifurcation analysis reveals that imperfections…

Fluid Dynamics · Physics 2025-08-26 Maria Vlachomitrou , Georges Chabouh , Alkmini Lytra , Nikos Pelekasis
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