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Tests of local realism and their applications aim for very high confidence in their results even in the presence of potentially adversarial effects. For this purpose, one can measure a quantity that reflects the amount of violation of local…

Quantum Physics · Physics 2013-11-26 Yanbao Zhang , Scott Glancy , Emanuel Knill

Cluster analysis is a fundamental research issue in statistics and machine learning. In many modern clustering methods, we need to determine whether two subsets of samples come from the same cluster. Since these subsets are usually…

Machine Learning · Computer Science 2025-07-15 Xinying Liu , Lianyu Hu , Mudi Jiang , Simeng Zhang , Jun Lou , Zengyou He

A definition for the statistical significance of a signal in an experiment is proposed by establishing a correlation between the observed p-value and the normal distribution integral probability, which is suitable for both counting…

Data Analysis, Statistics and Probability · Physics 2009-02-20 Yong-Sheng Zhu

Bell inequalities rest on three fundamental assumptions: realism, locality, and free choice, which lead to nontrivial constraints on correlations in very simple experiments. If we retain realism, then violation of the inequalities implies…

Quantum Physics · Physics 2021-05-20 Pawel Blasiak , Emmanuel M. Pothos , James M. Yearsley , Christoph Gallus , Ewa Borsuk

Experimentation platforms in industry must often deal with customer trust issues. Platforms must prove the validity of their claims as well as catch issues that arise. As a central quantity estimated by experimentation platforms, the…

Methodology · Statistics 2025-11-21 Kedar Karhadkar , Jack Klys , Daniel Ting , Artem Vorozhtsov , Houssam Nassif

Given a composite null hypothesis H, test supermartingales are non-negative supermartingales with respect to H with initial value 1. Large values of test supermartingales provide evidence against H. As a result, test supermartingales are an…

Statistics Theory · Mathematics 2020-03-27 Peter Wills , Emanuel Knill , Kevin Coakley , Yanbao Zhang

Several scientific fields including psychology are undergoing a replication crisis. There are many reasons for this problem, one of which is a misuse of p-values. There are several alternatives to p-values, and in this paper we describe a…

Methodology · Statistics 2020-10-05 Brian D. Segal

Modern statistics provides an ever-expanding toolkit for estimating unknown parameters. Consequently, applied statisticians frequently face a difficult decision: retain a parameter estimate from a familiar method or replace it with an…

Methodology · Statistics 2022-12-20 Brian L. Trippe , Sameer K. Deshpande , Tamara Broderick

It is widely acknowledged that the biomedical literature suffer from a surfeit of false positive results. Part of the reason for this is the persistence of the myth that observation of a p value less than 0.05 is sufficient justification to…

Applications · Statistics 2019-03-28 David Colquhoun

The ability to interpret machine learning models has become increasingly important as their usage in data science continues to rise. Most current interpretability methods are optimized to work on either (\textit{i}) a global scale, where…

Methodology · Statistics 2023-08-11 Emily T. Winn-Nuñez , Maryclare Griffin , Lorin Crawford

Statistical inference often conflates the probability of a parameter with the probability of a hypothesis, a critical misunderstanding termed the ultimate issue error. This error is pervasive across the social, biological, and medical…

Methodology · Statistics 2025-01-07 Stanley E. Lazic

We use p-values to identify the threshold level at which a regression function takes off from its baseline value, a problem motivated by applications in toxicological and pharmacological dose-response studies and environmental statistics.…

Methodology · Statistics 2011-06-13 Atul Mallik , Bodhisattva Sen , Moulinath Banerjee , George Michailidis

Researchers faced with a sequence of candidate model specifications must often choose the best specification that does not violate a testable identification assumption. One option in this scenario is sequential specification tests:…

Methodology · Statistics 2023-07-25 Adam C. Sales

When conducting large scale inference, such as genome-wide association studies or image analysis, nominal $p$-values are often adjusted to improve control over the family-wise error rate (FWER). When the majority of tests are null,…

Methodology · Statistics 2017-07-20 Sarah Fletcher Mercaldo , Jeffrey D. Blume

In meta analysis, multiple hypothesis testing and many other methods, p-values are utilized as inputs and assumed to be uniformly distributed over the unit interval under the null hypotheses. If data used to generate p-values have discrete…

Methodology · Statistics 2026-02-24 Joshua Habiger , Pratyaydipta Rudra

Pearson's correlation is among the mostly widely reported measures of association. The strength of the statistical evidence for linear association is determined by the p-value of a hypothesis test. If the true distribution of a dataset is…

Statistics Theory · Mathematics 2021-08-31 Marc Jaffrey , Michael Dushkoff

I proposed (8, 1, 3) that p values should be supplemented by an estimate of the false positive risk (FPR). FPR was defined as the probability that, if you claim that there is a real effect on the basis of p value from a single unbiased…

Other Statistics · Statistics 2020-08-10 David Colquhoun

The most popular multiple testing procedures are stepwise procedures based on $P$-values for individual test statistics. Included among these are the false discovery rate (FDR) controlling procedures of Benjamini--Hochberg [J. Roy. Statist.…

Statistics Theory · Mathematics 2009-06-18 Arthur Cohen , Harold B. Sackrowitz , Minya Xu

The literature on hypothesis testing with data-dependent and post-hoc significance levels relies on a particular extension of the Type-I error to data-dependent levels. Existing arguments for this extension are heuristic, and primarily…

Statistics Theory · Mathematics 2026-05-28 Nick W. Koning

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish…

Methodology · Statistics 2024-03-26 Jingyue Huang , Changbao Wu , Leilei Zeng