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Continuum kinetic simulations of plasmas, where the distribution function of the species is directly discretized in phase-space, permits fully kinetic simulations without the statistical noise of particle-in-cell methods. Recent advances in…

Computational Physics · Physics 2019-06-18 Petr Cagas , Ammar Hakim , Bhuvana Srinivasan

Calcium (Ca) plays an important role in regulating various cellular processes. In a variety of cell types, Ca signaling occurs within microdomains where channels deliver localized pulses of Ca which activate a nearby collection of…

Subcellular Processes · Quantitative Biology 2009-11-13 Robert Rovetti , Kunal K. Das , Alan Garfinkel , Yohannes Shiferaw

The periodic spatial modulation potential arising from the zig-zag distribution of ions at large gate voltage in an ionic liquid gated device may enable functionalities in a similar way as nanopatterning and moir\'e engineering. However,…

Mesoscale and Nanoscale Physics · Physics 2025-04-28 Qiao Chen , Chengyu Yan , Changshuai Lan , Qiyang Song , Yi Yan , Shun Wang

Recent years have witnessed an increasing interest in neuron-glia communication. This interest stems from the realization that glia participates in cognitive functions and information processing and is involved in many brain disorders and…

Neurons and Cognition · Quantitative Biology 2009-12-17 Maurizio De Pitta` , Mati Goldberg , Vladislav Volman , Hugues Berry , Eshel Ben-Jacob

We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map.…

Biological Physics · Physics 2009-11-10 Yohannes Shiferaw , Daisuke Sato , Alain Karma

The physical mechanism underlying the voltage-dependent gating of K channels is usually addressed theoretically using molecular dynamics simulations.However, besides being computationally very expensive, this approach is presently unable to…

Biological Physics · Physics 2020-01-08 Luigi Catacuzzeno , Fabio Franciolini

In this paper we use a spin kinetic equation to study spin polarization dynamics in 1D wires and 2D channels. This approach is valid in both diffusive and ballistic spin transport regimes and, therefore, more general than the usual spin…

Mesoscale and Nanoscale Physics · Physics 2011-10-17 V. A. Slipko , Y. V. Pershin

Channel-mediated transport is ubiquitous in biology. A series of works by different theoreticians have sought to determine how the diffusive flux through a channel depends on (a) stochastic gating, (b) channel geometry, and (c)…

Statistical Mechanics · Physics 2026-03-17 Sean D Lawley

The space-time dynamics of rigid inhomogeneities (inclusions) free to move in a randomly fluctuating fluid bio-membrane is derived and numerically simulated as a function of the membrane shape changes. Both vertically placed (embedded)…

Computational Physics · Physics 2007-05-23 H. Rafii-Tabar , H. R. Sepangi

The presynaptic free calcium dynamics of neurons due to various stimulation protocols is investigated in a mathematical model. The model includes calcium influx through voltage-dependent calcium channels, calcium buffering by endogenous and…

Biological Physics · Physics 2007-05-23 Frido Erler , Michael Meyer-Hermann , Gerhard Soff

Electrical signals in excitable cells involve spatially localized ionic fluxes through ion channels and pumps on cellular lipid membranes. Common approaches to understand how these localized fluxes spread assume that the membrane and the…

Soft Condensed Matter · Physics 2024-07-17 Hyeongjoo Row , Joshua B. Fernandes , Kranthi K. Mandadapu , Karthik Shekhar

Understanding the role of astrocytes in brain computation is a nascent challenge, promising immense rewards, in terms of new neurobiological knowledge that can be translated into artificial intelligence. In our ongoing effort to identify…

Neurons and Cognition · Quantitative Biology 2018-07-10 Ioannis Polykretis , Vladimir Ivanov , Konstantinos P. Michmizos

This paper presents in-depth analysis of the excitable membranes of a biological system. We rigorously prove from the Chay neuron model that the state dependent voltage-sensitive potassium ion-channel and calcium sensitive potassium…

Systems and Control · Electrical Eng. & Systems 2020-05-13 Maheshwar Sah , Ram Kaji Budhathoki

The process of ion transport through a locust potassium channel is described by means of the Fokker-Planck equation (FPE). The deterministic and stochastic components of the process of switching between various conducting states of the…

Statistical Mechanics · Physics 2009-11-10 M. Ausloos , K. Ivanova , Z. Siwy

Stochastic transitions between discrete microscopic states play an important role in many physical and biological systems. Often, these transitions lead to fluctuations on a macroscopic scale. A classic example from neuroscience is the…

Statistical Mechanics · Physics 2024-02-20 Lukas Ramlow , Benjamin Lindner

Deciphering the complex interactions between neurotransmission and astrocytic $Ca^{2+}$ elevations is a target promising a comprehensive understanding of brain function. While the astrocytic response to excitatory synaptic activity has been…

Cell Behavior · Quantitative Biology 2019-03-19 Ioannis E. Polykretis , Vladimir A. Ivanov , Konstantinos P. Michmizos

Mitochondrial calcium handling is a particularly active research area in the neuroscience field, as it plays key roles in the regulation of several functions of the central nervous system, such as synaptic transmission and plasticity,…

Neurons and Cognition · Quantitative Biology 2024-08-23 Roman Serrat , Alexandre Oliveira-Pinto , Giovanni Marsicano , Sandrine Pouvreau

Specific molecular interactions underlie unexpected and useful phenomena in nanofluidic systems, but require descriptions that go beyond traditional macroscopic hydrodynamics. In this letter, we demonstrate how equilibrium molecular…

Mesoscale and Nanoscale Physics · Physics 2023-06-07 Phillip Helms , Anthony R. Poggioli , David T. Limmer

We study the selective excitation at infrared and THz frequencies of optical and acoustic plasmonic modes supported by thin topological insulators. These modes are characterized by effective net charge or net spin density, respectively, and…

Mesoscale and Nanoscale Physics · Physics 2018-11-12 M. Ameen Poyli , M. Hrtoň , I. A. Nechaev , A. Nikitin , P. M. Echenique , V. M. Silkin , J. Aizpurua , R. Esteban

In this article we develop an algorithm for the efficient simulation of electrolytes in the presence of physical boundaries. In previous work the Discrete Ion Stochastic Continuum Overdamped Solvent (DISCOS) algorithm was derived for triply…