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We introduce SynFormer, a generative modeling framework designed to efficiently explore and navigate synthesizable chemical space. Unlike traditional molecular generation approaches, we generate synthetic pathways for molecules to ensure…

Machine Learning · Computer Science 2024-10-07 Wenhao Gao , Shitong Luo , Connor W. Coley

The Geant4 toolkit is the standard for simulating the passage of particles through matter, but its conventional architecture often requires users to modify and recompile C++ code to alter fundamental simulation parameters such as geometry,…

High Energy Physics - Experiment · Physics 2025-12-13 Jing Liu

The discovery of new functional and stable materials is a big challenge due to its complexity. This work aims at the generation of new crystal structures with desired properties, such as chemical stability and specified chemical…

Computational Physics · Physics 2023-10-18 Arsen Sultanov , Jean-Claude Crivello , Tabea Rebafka , Nataliya Sokolovska

The emergence of deep learning has brought the long-standing goal of comprehensively understanding and exploring crystalline materials closer to reality. Yet, universal exploration across all elements remains hindered by the combinatorial…

Materials Science · Physics 2025-11-18 Fengyu Xie , Ruoyu Wang , Taoyuze Lv , Yuxiang Gao , Hongyu Wu , Zhicheng Zhong

Establishing structure-property linkages in polycrystalline materials requires representative two- (2D) and three- (3D) dimensional microstructural inputs for full-field simulations. A core objective of microstructure characterization and…

Generative design marks a significant data-driven advancement in the exploration of novel inorganic materials, which entails learning the symmetry equivalent to the crystal structure prediction (CSP) task and subsequent learning of their…

Materials Science · Physics 2024-03-22 Ruiming Zhu , Wei Nong , Shuya Yamazaki , Kedar Hippalgaonkar

Discovering materials with new structural chemistry is key to achieving transformative functionality. Generative artificial intelligence offers a scalable route to propose candidate crystal structures. We introduce a reliable low-cost proxy…

Crystal structures can be viewed as assemblies of space-filling polyhedra, which play a critical role in determining material properties such as ionic conductivity and dielectric constant. However, most conventional crystal structure…

Materials Science · Physics 2026-03-20 Tomoyasu Yokoyama , Kazuhide Ichikawa , Hisashi Naito

A novel Genetic Algorithm is described that is suitable for determining the global minimum energy configurations of crystal structures and which can also be used as a polymorph search technique. This algorithm requires no prior assumptions…

Other Condensed Matter · Physics 2007-05-23 N. L. Abraham , M. I. J. Probert

We present PyXtal, a new package based on the Python programming language, used to generate structures with specific symmetry and chemical compositions for both atomic and molecular systems. This soft ware provides support for various…

Materials Science · Physics 2021-10-05 Scott Fredericks , Kevin Parrish , Dean Sayre , Qiang Zhu

Molecular structure recognition is the task of translating a molecular image into its graph structure. Significant variation in drawing styles and conventions exhibited in chemical literature poses a significant challenge for automating…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Yujie Qian , Jiang Guo , Zhengkai Tu , Zhening Li , Connor W. Coley , Regina Barzilay

Proteins power a vast array of functional processes in living cells. The capability to create new proteins with designed structures and functions would thus enable the engineering of cellular behavior and development of protein-based…

Biomolecules · Quantitative Biology 2023-06-08 Yeqing Lin , Mohammed AlQuraishi

This article presents GRFsaw, an open-source software for generating two-phase (binary) microstructures with user-defined structural properties. Unlike most standard software for microstructure generation, GRFsaw is based on the concept of…

Computational Engineering, Finance, and Science · Computer Science 2024-12-09 Lars Blatny , Henning Löwe , Johan Gaume

Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties. Generated structures can be utilized for…

Generative modeling has emerged as a promising approach for crystal structure discovery. However, existing LLM-based generative models struggle with low-level atomic precision, while diffusion-based methods fall short in integrating…

Artificial Intelligence · Computer Science 2026-05-18 Yuyang Wu , Stefano Falletta , Delia McGrath , Sherry Yang

In the field of material design, traditional crystal structure prediction approaches require extensive structural sampling through computationally expensive energy minimization methods using either force fields or quantum mechanical…

Generative machine learning (ML) models hold great promise for accelerating materials discovery through the inverse design of inorganic crystals, enabling an unprecedented exploration of chemical space. Yet, the lack of standardized…

Generative models have demonstrated remarkable potential in time series analysis tasks, like synthesis, forecasting, imputation, etc. However, offering limited coverage for generative models, existing time series libraries are mainly…

Machine Learning · Computer Science 2026-05-20 Chenxi Wang , Xiaorong Wang , Peiyang Li , Yi Wang

We propose a new architecture and training methodology for generative adversarial networks. Current approaches attempt to learn the transformation from a noise sample to a generated data sample in one shot. Our proposed generator…

Machine Learning · Computer Science 2018-11-26 Safwan Hossain , Kiarash Jamali , Yuchen Li , Frank Rudzicz

The computational prediction of atomistic structure is a long-standing problem in physics, chemistry, materials, and biology. Within conventional force-field or {\em ab initio} calculations, structure is determined through energy…

Chemical Physics · Physics 2021-09-15 Dominik Lemm , Guido Falk von Rudorff , O. Anatole von Lilienfeld