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External biasing forces are often applied to enhance sampling in regions of phase space which would otherwise be rarely observed. While the typical goal of these experiments is to calculate the potential of mean force (PMF) along the…

Statistical Mechanics · Physics 2010-10-27 David D. L. Minh

Data-driven dynamics prediction often fails under environmental shifts, while traditional fine-tuning remains computationally prohibitive for hardware-constrained or data-scarce applications. We propose DynaDiff, a generative meta-learning…

Computational Engineering, Finance, and Science · Computer Science 2026-05-05 Ruikun Li , Huandong Wang , Jingtao Ding , Yuan Yuan , Qingmin Liao , Yong Li

We consider the rate of transition for a particle between two metastable states coupled to a thermal environment for various magnitudes of the coupling strength, using the recently proposed infrequent metadynamics approach (Tiwary and…

Soft Condensed Matter · Physics 2016-05-04 Pratyush Tiwary , B. J. Berne

Neural network (NN) model chemistries (MCs) promise to facilitate the accurate exploration of chemical space and simulation of large reactive systems. One important path to improving these models is to add layers of physical detail,…

Chemical Physics · Physics 2018-04-04 John E. Herr , Kun Yao , Ryker McIntyre , David Toth , John Parkhill

Dynamic critical behavior in superfluid systems is considered in a presence of external stirring and advecting processes. The latter are generated by means of the Gaussian random velocity ensemble with white-noise character in time variable…

Statistical Mechanics · Physics 2020-08-19 Michal Dančo , Michal Hnatič , Tomáš Lučivjanský , Lukáš Mižišin

The inverse design of metasurfaces faces inherent challenges due to the nonlinear and highly complex relationship between geometric configurations and their electromagnetic behavior. Traditional optimization approaches often suffer from…

In light of the widespread success of generative models, a significant amount of research has gone into speeding up their sampling time. However, generative models are often sampled multiple times to obtain a diverse set incurring a cost…

Machine Learning · Computer Science 2023-11-27 Gabriele Corso , Yilun Xu , Valentin de Bortoli , Regina Barzilay , Tommi Jaakkola

This paper introduces an approach to endow generative diffusion processes the ability to satisfy and certify compliance with constraints and physical principles. The proposed method recast the traditional sampling process of generative…

Machine Learning · Computer Science 2024-11-05 Jacob K Christopher , Stephen Baek , Ferdinando Fioretto

We investigate a new sampling scheme aimed at improving the performance of particle filters whenever (a) there is a significant mismatch between the assumed model dynamics and the actual system, or (b) the posterior probability tends to…

Computation · Statistics 2019-03-20 Ömer Deniz Akyıldız , Joaquín Míguez

We consider the problem of sampling from the ferromagnetic $q$-state Potts model on the random $d$-regular graph with parameter $\beta>0$. A key difficulty that arises in sampling from the model is the existence of a metastability window…

Probability · Mathematics 2026-02-16 Andreas Galanis , Leslie Ann Goldberg , Paulina Smolarova

Understanding protein conformational dynamics is essential for elucidating biological function but remains challenging due to the wide range of timescales and the complexity of collective motions. Enhanced sampling methods overcome…

Statistical Mechanics · Physics 2026-05-11 Souvik Mondal , Michael A. Sauer , Matthias Heyden

Dynamic data selection accelerates training by sampling a changing subset of the dataset while preserving accuracy. We rethink two core notions underlying sample evaluation: representativeness and diversity. Instead of local geometric…

Artificial Intelligence · Computer Science 2026-03-06 Yuzhe Zhou , Zhenglin Hua , Haiyun Guo , Yuheng Jia

Ensembles are a straightforward, remarkably effective method for improving the accuracy,calibration, and robustness of models on classification tasks; yet, the reasons that underlie their success remain an active area of research. We build…

Machine Learning · Statistics 2022-06-22 Neha Gupta , Jamie Smith , Ben Adlam , Zelda Mariet

Statistical thermodynamics has a universal appeal that extends beyond molecular systems, and yet, as its tools are being transplanted to fields outside physics, the fundamental question, \textit{what is thermodynamics?}, has remained…

Statistical Mechanics · Physics 2019-09-17 Themis Matsoukas

This paper presents a novel technique for state space reduction of probabilistic specifications, based on a newly developed notion of confluence for probabilistic automata. We prove that this reduction preserves branching probabilistic…

Logic in Computer Science · Computer Science 2010-11-11 Mark Timmer , Mariëlle Stoelinga , Jaco van de Pol

Model-based reinforcement learning methods often use learning only for the purpose of estimating an approximate dynamics model, offloading the rest of the decision-making work to classical trajectory optimizers. While conceptually simple,…

Machine Learning · Computer Science 2022-12-22 Michael Janner , Yilun Du , Joshua B. Tenenbaum , Sergey Levine

Decision-guided perspectives on model uncertainty expand traditional statistical thinking about managing, comparing and combining inferences from sets of models. Bayesian predictive decision synthesis (BPDS) advances conceptual and…

Methodology · Statistics 2023-05-09 Emily Tallman , Mike West

We present a new algorithm to optimize distributions defined implicitly by parameterized stochastic diffusions. Doing so allows us to modify the outcome distribution of sampling processes by optimizing over their parameters. We introduce a…

The original formulation of BEAMS - Bayesian Estimation Applied to Multiple Species - showed how to use a dataset contaminated by points of multiple underlying types to perform unbiased parameter estimation. An example is cosmological…

Instrumentation and Methods for Astrophysics · Physics 2016-03-02 James Newling , Bruce. A. Bassett , Renée Hlozek , Martin Kunz , Mathew Smith , Melvin Varughese

A composite likelihood is an inference function derived by multiplying a set of likelihood components. This approach provides a flexible framework for drawing inference when the likelihood function of a statistical model is computationally…

Methodology · Statistics 2024-12-10 Giuseppe Alfonzetti , Ruggero Bellio , Yunxiao Chen , Irini Moustaki