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Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain an unmet clinical need in PD. In this…

Applications · Statistics 2018-10-04 R Prashanth , Sumantra Dutta Roy

Parkinson's disease (PD), characterized by its incurable nature, rapid progression, and severe disability, poses significant challenges to the lives of patients and their families. Given the aging population, the need for early detection of…

Computer Vision and Pattern Recognition · Computer Science 2025-06-24 Wei Huang , Yinxuan Xu , Yintao Zhou , Zhengyu Li , Jing Huang , Meng Pang

Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

Parkinson's disease (PD) is one of the major public health problems in the world. It is a well-known fact that around one million people suffer from Parkinson's disease in the United States whereas the number of people suffering from…

Machine Learning · Computer Science 2016-10-27 Kamal Nayan Reddy Challa , Venkata Sasank Pagolu , Ganapati Panda , Babita Majhi

Parkinson's disease (PD) is a neurodegenerative disease affecting about 1% of people over the age of 60, causing motor impairments that impede hand coordination activities such as writing and drawing. Many approaches have tried to support…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Mhd Adnan Albani , Riad Sonbol

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

Parkinson's Disease (PD) is a neurological disorder that affects facial movements and non-verbal communication. Patients with PD present a reduction in facial movements called hypomimia which is evaluated in item 3.2 of the MDS-UPDRS-III…

Computer Vision and Pattern Recognition · Computer Science 2020-12-14 Luis Felipe Gomez-Gomez , Aythami Morales , Julian Fierrez , Juan Rafael Orozco-Arroyave

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair…

Machine Learning · Computer Science 2025-04-07 Masahiro Matsumoto , Abu Saleh Musa Miah , Nobuyoshi Asai , Jungpil Shin

With the mass construction of Gen III nuclear reactors, it is a popular trend to use deep learning (DL) techniques for fast and effective diagnosis of possible accidents. To overcome the common problems of previous work in diagnosing…

Signal Processing · Electrical Eng. & Systems 2022-09-26 Chengyuan Li , Zhifang Qiu , Zhangrui Yan , Meifu Li

Eye-tracking is an accessible and non-invasive technology that provides information about a subject's motor and cognitive abilities. As such, it has proven to be a valuable resource in the study of neurodegenerative diseases such as…

Machine Learning · Computer Science 2023-11-29 Gonzalo Uribarri , Simon Ekman von Huth , Josefine Waldthaler , Per Svenningsson , Erik Fransén

Efficient early diagnosis is paramount in addressing the complexities of Parkinson's disease because timely intervention can substantially mitigate symptom progression and improve patient outcomes. In this paper, we present a pioneering…

Signal Processing · Electrical Eng. & Systems 2024-04-25 Alireza Rashnu , Armin Salimi-Badr

Parkinson's disease (PD), a prevalent neurodegenerative disorder, significantly affects patients' daily functioning and social interactions. To facilitate a more efficient and accessible diagnostic approach for PD, we propose a dynamic…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Xiaochen Huang , Xiaochen Bi , Cuihua Lv , Xin Wang , Haoyan Zhang , Wenjing Jiang , Xin Ma , Yibin Li

Characterising the heterogeneous presentation of Parkinson's disease (PD) requires integrating biological and clinical markers within a unified predictive framework. While multimodal data provide complementary information, many existing…

Machine Learning · Computer Science 2026-01-05 Dristi Datta , Tanmoy Debnath , Minh Chau , Manoranjan Paul , Gourab Adhikary , Md Geaur Rahman

Deep Convolutional Neural Networks (CNNs) are becoming prominent models for semi-automated diagnosis of Alzheimer's Disease (AD) using brain Magnetic Resonance Imaging (MRI). Although being highly accurate, deep CNN models lack transparency…

Machine Learning · Computer Science 2020-04-28 Eduardo Nigri , Nivio Ziviani , Fabio Cappabianco , Augusto Antunes , Adriano Veloso

Accurate and interpretable gait analysis plays a crucial role in the early detection of Parkinsons disease (PD),yet most existing approaches remain limited by single-modality inputs, low robustness, and a lack of clinical transparency. This…

Computer Vision and Pattern Recognition · Computer Science 2025-12-05 Manar Alnaasan , Md Selim Sarowar , Sungho Kim

Deep-learning (DL)-based methods have shown significant promise in denoising myocardial perfusion SPECT images acquired at low dose. For clinical application of these methods, evaluation on clinical tasks is crucial. Typically, these…

Image and Video Processing · Electrical Eng. & Systems 2023-03-02 Md Ashequr Rahman , Zitong Yu , Barry A. Siegel , Abhinav K. Jha

Accurate diagnosis of Parkinson disease, especially in its early stages, can be a challenging task. The application of machine learning techniques helps improve the diagnostic accuracy of Parkinson disease detection but only few studies…

Machine Learning · Computer Science 2024-12-25 Majid Ali , Hina Shakir , Asia Samreen , Sohaib Ahmed

Parkinson's Disease (PD) is a degenerative neurological disorder that impairs motor and non-motor functions, significantly reducing quality of life and increasing mortality risk. Early and accurate detection of PD progression is vital for…

Machine Learning · Computer Science 2024-12-31 Abhinav Roy , Bhavesh Gyanchandani , Aditya Oza , Abhishek Sharma

Parkinson's disease (PD) is a debilitating neurological disorder that necessitates precise and early diagnosis for effective patient care. This study aims to develop a diagnostic model capable of achieving both high accuracy and minimizing…

Machine Learning · Computer Science 2024-01-30 Seyedeh Zahra Seyedi Hosseininian , Ahmadreza Tajari , Mohsen Ghalehnoie , Alireza Alfi

Deep learning (DL) models have shown significant potential in Alzheimer's Disease (AD) classification. However, understanding and interpreting these models remains challenging, which hinders the adoption of these models in clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-09-10 Thomas Yu Chow Tam , Litian Liang , Ke Chen , Haohan Wang , Wei Wu