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Attenuation correction is an essential requirement of positron emission tomography (PET) image reconstruction to allow for accurate quantification. However, attenuation correction is particularly challenging for PET-MRI as neither PET nor…

Current methods for magnetic resonance-based positron emission tomography attenuation correction (PET-MR AC) are time consuming, and less able than computed tomography (CT)-based AC methods to capture inter-individual variability and skull…

Positron Emission Tomography (PET) imaging requires accurate attenuation correction (AC) to account for photon loss due to tissue density variations. In PET/MR systems, computed tomography (CT), which offers a straightforward estimation of…

Image and Video Processing · Electrical Eng. & Systems 2025-04-11 Weijie Chen , James Wang , Alan McMillan

With the increasing popularity of PET-MR scanners in clinical applications, synthesis of CT images from MR has been an important research topic. Accurate PET image reconstruction requires attenuation correction, which is based on the…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Snehashis Roy , John A. Butman , Dzung L. Pham

Deep-learning-based MR-to-CT synthesis can estimate the electron density of tissues, thereby facilitating PET attenuation correction in whole-body PET/MR imaging. However, whole-body MR-to-CT synthesis faces several challenges including the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Jiaxu Zheng , Zhenrong Shen , Lichi Zhang , Qun Chen

Accurate quantification in positron emission tomography (PET) is essential for accurate diagnostic results and effective treatment tracking. A major issue encountered in PET imaging is attenuation. Attenuation refers to the diminution of…

Historically, patient datasets have been used to develop and validate various reconstruction algorithms for PET/MRI and PET/CT. To enable such algorithm development, without the need for acquiring hundreds of patient exams, in this paper we…

In PET/CT imaging, CT is used for PET attenuation correction (AC). Mismatch between CT and PET due to patient body motion results in AC artifacts. In addition, artifact caused by metal, beam-hardening and count-starving in CT itself also…

Image and Video Processing · Electrical Eng. & Systems 2019-09-05 Luyao Shi , John A. Onofrey , Enette Mae Revilla , Takuya Toyonaga , David Menard , Jo-seph Ankrah , Richard E. Carson , Chi Liu , Yihuan Lu

Large high-quality medical image datasets are difficult to acquire but necessary for many deep learning applications. For positron emission tomography (PET), reconstructed image quality is limited by inherent Poisson noise. We propose a…

Attenuation correction (AC) is essential for the generation of artifact-free and quantitatively accurate positron emission tomography (PET) images. However, AC of PET faces challenges including inter-scan motion and erroneous transformation…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Yu Guan , Bohui Shen , Xinchong Shi , Xiangsong Zhang , Bingxuan Li , Qiegen Liu

Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR…

Medical Physics · Physics 2018-08-01 Kuang Gong , Jaewon Yang , Kyungsang Kim , Georges El Fakhri , Youngho Seo , Quanzheng Li

Deep-neural-network-based image reconstruction has demonstrated promising performance in medical imaging for under-sampled and low-dose scenarios. However, it requires large amount of memory and extensive time for the training. It is…

Computer Vision and Pattern Recognition · Computer Science 2019-06-12 Dufan Wu , Kyungsang Kim , Quanzheng Li

Deep convolutional neural networks (DCNN) have demonstrated its capability to convert MR image to pseudo CT for PET attenuation correction in PET/MRI. Conventionally, attenuated events are corrected in sinogram space using attenuation maps…

Computer Vision and Pattern Recognition · Computer Science 2019-05-22 Jaewon Yang , Dookun Park , Jae Ho Sohn , Zhen Jane Wang , Grant T. Gullberg , Youngho Seo

Increasing use of CT in modern medical practice has raised concerns over associated radiation dose. Reduction of radiation dose associated with CT can increase noise and artifacts, which can adversely affect diagnostic confidence. Denoising…

Computer Vision and Pattern Recognition · Computer Science 2017-02-24 Qingsong Yang , Pingkun Yan , Mannudeep K. Kalra , Ge Wang

MRI-guided radiation treatment planning is widely applied because of its superior soft-tissue contrast and no ionization radiation compared to CT-based planning. In this regard, synthetic CT (sCT) images should be generated from the…

Medical Physics · Physics 2021-05-14 Abbas Bahrami , Alireza Karimian , Hossein Arabi

Computed tomography (CT) is a widely used imaging modality for medical diagnosis and treatment. In electroencephalography (EEG), CT imaging is necessary for co-registering with magnetic resonance imaging (MRI) and for creating more accurate…

Medical Physics · Physics 2019-06-12 Andreas D. Lauritzen , Xenophon Papademetris , Sergei Turovets , John A. Onofrey

This paper strives to generate a synthetic computed tomography (CT) image from a magnetic resonance (MR) image. The synthetic CT image is valuable for radiotherapy planning when only an MR image is available. Recent approaches have made…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Zenglin Shi , Pascal Mettes , Guoyan Zheng , Cees Snoek

Recent work has shown improved lesion detectability and flexibility to reconstruction hyperparameters (e.g. scanner geometry or dose level) when PET images are reconstructed by leveraging pre-trained diffusion models. Such methods train a…

Medical Physics · Physics 2025-08-28 George Webber , Alexander Hammers , Andrew P. King , Andrew J. Reader

Model-based treatment planning for transcranial ultrasound therapy typically involves mapping the acoustic properties of the skull from an x-ray computed tomography (CT) image of the head. Here, three methods for generating pseudo-CT images…

Purpose: To assess the feasibility of deep learning-based high resolution synthetic CT generation from MRI scans of the lower arm for orthopedic applications. Methods: A conditional Generative Adversarial Network was trained to synthesize…

Computer Vision and Pattern Recognition · Computer Science 2019-01-25 Frank Zijlstra , Koen Willemsen , Mateusz C. Florkow , Ralph J. B. Sakkers , Harrie H. Weinans , Bart C. H. van der Wal , Marijn van Stralen , Peter R. Seevinck
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