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As an emergent infectious disease outbreak unfolds, public health response is reliant on information on key epidemiological quantities, such as transmission potential and serial interval. Increasingly, transmission models fit to incidence…

Populations and Evolution · Quantitative Biology 2015-06-29 Aaron A. King , Matthieu Domenech de Cellès , Felicia M. G. Magpantay , Pejman Rohani

Stochastic compartmental models are important tools for understanding the course of infectious diseases epidemics in populations and in prospective evaluation of intervention policies. However, calculating the likelihood for discretely…

Computation · Statistics 2018-07-26 Lam Si Tung Ho , Forrest W. Crawford , Marc A. Suchard

The data for the Ebola outbreak that occurred in 2014-2016 in three countries of West Africa are analysed within a common framework. The analysis is made using the results of an agent based Susceptible-Infected-Removed (SIR) model on a…

Physics and Society · Physics 2017-02-02 Abdul Khaleque , Parongama Sen

In this paper we introduce an approach to the management of infectious disease diffusion through the formulation of a controlled compartmental SVIR (Susceptible-Vaccinated-Infected-Recovered) model. We consider a cost functional…

Optimization and Control · Mathematics 2023-11-28 Alessandro Ramponiand M. Elisabetta Tessitore

The Ebola virus and the disease in effect tend to randomly move individuals in the population around susceptible, infected, quarantined, hospitalized, recovered, and dead sub-population. Motivated by the effectiveness in propagating the…

Artificial Intelligence · Computer Science 2021-06-22 Olaide N. Oyelade , Absalom E. Ezugwu

We study the optimal control problem of allocating campaigning resources over the campaign duration and degree classes in a social network. Information diffusion is modeled as a Susceptible-Infected epidemic and direct recruitment of…

Social and Information Networks · Computer Science 2016-10-27 Kundan Kandhway , Joy Kuri

Throughout the course of an epidemic, the rate at which disease spreads varies with behavioral changes, the emergence of new disease variants, and the introduction of mitigation policies. Estimating such changes in transmission rates can…

Methodology · Statistics 2022-11-29 Jenny Huang , Raphaël Morsomme , David Dunson , Jason Xu

We present a comparison between two different mathematical models used in the description of the Ebola virus propagation currently occurring in West Africa. In order to improve the prediction and the control of the propagation of the virus,…

Populations and Evolution · Quantitative Biology 2017-11-06 Amira Rachah , Delfim F. M. Torres

In this paper, an SIR epidemic model with variable size of population is considered. We study optimal control problem for an SIR model with "vaccination" and "treatment" as controls. It is shown that an optimal control exists. We have…

Optimization and Control · Mathematics 2016-12-28 Olga Klimenkova

In this work, we investigate a VS-EIAR epidemiological model that incorporates vaccinated individuals $\{V_i : i = 1, \ldots, n\}$, where $n \in \mathbb{N}^{*}$. The dynamics of the VS-EIAR model are governed by a system of ordinary…

Dynamical Systems · Mathematics 2025-07-16 Mamadou Abdoul Diop , Mohammed Elghandouri , Khalil Ezzinbi

An Ebola outbreak of unparalleled size is currently affecting several countries in West Africa, and international efforts to control the outbreak are underway. However, the efficacy of these interventions, and their likely impact on an…

Populations and Evolution · Quantitative Biology 2014-09-23 Caitlin M. Rivers , Eric T. Lofgren , Madhav Marathe , Stephen Eubank , Bryan L. Lewis

This paper analyses the optimal control of infectious disease propagation using a classic susceptible-infected-recovered (SIR) model characterised by permanent immunity and the absence of available vaccines. The control is performed over a…

Optimization and Control · Mathematics 2024-06-12 Rocío Balderrama , Mariana Inés Prieto , Constanza Sánchez de la Vega , Federico Vazquez

We analyze a class of general nonlinear epidemic models with age and space structure, including a nonlocal infection term depending on age and space. After establishing the well-posedness of the state partial differential equation, we…

Optimization and Control · Mathematics 2025-03-11 Behzad Azmi , Nicolas Schlosser

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

Systems and Control · Electrical Eng. & Systems 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

A deterministic mathematical model is formulated and analyzed to study the transmission dynamics of Nipah virus both qualitatively and numerically. Existence and stability of equilibria were investigated and the model was rigorously…

Dynamical Systems · Mathematics 2020-10-09 BI Omede , PO Ameh , A Omame , B Bolaji

This paper proposes a feedback design that effectively copes with uncertainties for reliable epidemic monitoring and control. There are several optimization-based methods to estimate the parameters of an epidemic model by utilizing past…

Optimization and Control · Mathematics 2023-04-06 Muhammad Umar B. Niazi , Philip E. Paré , Karl H. Johansson

Controlling an epidemiological model is often performed using optimal control theory techniques for which the solution depends on the equations of the control system, objective functional and possible state and/or control constraints. In…

Optimization and Control · Mathematics 2021-11-25 Loïc Michel , Cristiana J. Silva , Delfim F. M. Torres

We introduce a general system of ordinary differential equations that includes some classical and recent models for the epidemic spread in a closed population without vital dynamic in a finite time horizon. The model is vectorial, in the…

Optimization and Control · Mathematics 2023-06-21 Lorenzo Freddi

Epidemic risk assessment poses inherent challenges, with traditional approaches often failing to balance health outcomes and economic constraints. This paper presents a data-driven decision support tool that models epidemiological dynamics…

Applications · Statistics 2025-11-24 Chang Zhai , Ping Chen , Zhuo Jin , David Pitt

We formulate a two-patch mathematical model for Ebola Virus Disease dynamics in order to evaluate the effectiveness of \textit{cordons sanitaires}, mandatory movement restrictions between communities while exploring their role on disease…

Populations and Evolution · Quantitative Biology 2015-10-27 Baltazar Espinoza , Victor Moreno , Derdei Bichara , Carlos Castillo-Chavez