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Research on chemotherapy, heart surgery, and vaccines has indicated that the risks and benefits of a treatment could vary depending on the time of day it is administered. A challenge with performing studies on timing treatment…
Understanding the sleep quality and architecture is essential to human being's health, which is usually represented using multiple sleep stages. A standard sleep stage determination requires Electroencephalography (EEG) signals during the…
Drowsiness can put lives of many drivers and workers in danger. It is important to design practical and easy-to-deploy real-world systems to detect the onset of drowsiness.In this paper, we address early drowsiness detection, which can…
The circadian clock is an internal timer that coordinates the daily rhythms of behavior and physiology, including sleep and hormone secretion. Accurately tracking the state of the circadian clock, or circadian phase, holds immense potential…
Characterizing the sleep-wake cycle in adolescents is an important prerequisite to better understand the association of abnormal sleep patterns with subsequent clinical and behavioral outcomes. The aim of this research was to develop hidden…
Sleep is essential for the maintenance of the brain and the body, yet many features of sleep are poorly understood and mathematical models are an important tool for probing proposed biological mechanisms. The most well-known mathematical…
For quantitative evaluation of sleep disturbances, a noninvasive monitoring system is developed by introducing an event-based method. We observe sleeping in home context and classify the sleep disturbances into three types of events: motion…
A biophysical model of arousal dynamics is used to study mechanisms of synchronisation and loss of synchrony among the three key oscillators controlling sleep-wake cycles: the circadian, homeostatic, and light oscillators. Synchronisation…
Gene expression levels, hormone secretion, and internal body temperature each oscillate over an approximately 24-hour cycle, or display circadian rhythms. Many circadian biology studies have investigated how these rhythms vary across…
Closed-loop sleep modulation is an emerging research paradigm to treat sleep disorders and enhance sleep benefits. However, two major barriers hinder the widespread application of this research paradigm. First, subjects often need to be…
In this paper, we propose a novel method and a practical approach to predicting early onsets of sleep syndromes, including restless leg syndrome, insomnia, based on an algorithm that is comprised of two modules. A Fast Fourier Transform is…
Sleep detection and annotation are crucial for researchers to understand sleep patterns, especially in children. With modern wrist-worn watches comprising built-in accelerometers, sleep logs can be collected. However, the annotation of…
Much attention has been given to automatic sleep staging algorithms in past years, but the detection of discrete events in sleep studies is also crucial for precise characterization of sleep patterns and possible diagnosis of sleep…
This paper presents MIS-LSTM, a hybrid framework that joins CNN encoders with an LSTM sequence model for sleep quality and stress prediction at the day level from multimodal lifelog data. Continuous sensor streams are first partitioned into…
Humans spend vast hours in bed -- about one-third of the lifetime on average. Besides, a human at rest is vital in many healthcare applications. Typically, humans are covered by a blanket when resting, for which we propose a multimodal…
Cortical arousals are transient events of disturbed sleep that occur spontaneously or in response to stimuli such as apneic events. The gold standard for arousal detection in human polysomnographic recordings (PSGs) is manual annotation by…
The cosinor model is frequently used to represent the oscillatory behavior of different genes over time. When data are collected from multiple individuals, the cosinor model is estimated with recorded gene expression levels and the 24 hour…
We study downlink (DL) channel estimation in a multi-cell Massive multiple-input multiple-output (MIMO) system operating in a time-division duplex. The users must know their effective channel gains to decode their received DL data signals.…
Circadian disruption contributes to adverse effects on sleep, performance, and health. One accepted method to track continuous daily changes in circadian timing is to measure core body temperature (CBT), and establish daily,…
Sleep constitutes a key indicator of human health, performance, and quality of life. Sleep deprivation has long been related to the onset, development, and worsening of several mental and metabolic disorders, constituting an essential…