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We analyze the solutions, on single network instances, of a recently introduced class of constraint-satisfaction problems (CSPs), describing feasible steady states of chemical reaction networks. First, we show that the CSPs generalize the…

Molecular Networks · Quantitative Biology 2014-03-05 Alessandro Seganti , Federico Ricci-Tersenghi , Andrea De Martino

We define and study a class of (random) Boolean constraint satisfaction problems representing minimal feasibility constraints for networks of chemical reactions. The constraints we consider encode, respectively, for hard mass-balance…

Molecular Networks · Quantitative Biology 2014-10-14 Alessandro Seganti , Andrea De Martino , Federico Ricci-Tersenghi

Boolean networks model finite discrete dynamical systems with complex behaviours. The state of each component is determined by a Boolean function of the state of (a subset of) the components of the network. This paper addresses the…

Artificial Intelligence · Computer Science 2020-02-28 Stéphanie Chevalier , Christine Froidevaux , Loïc Paulevé , Andrei Zinovyev

Finding actions that satisfy the constraints imposed by both external inputs and internal representations is central to decision making. We demonstrate that some important classes of constraint satisfaction problems (CSPs) can be solved by…

Neurons and Cognition · Quantitative Biology 2018-01-16 Ueli Rutishauser , Jean-Jacques Slotine , Rodney J. Douglas

An active topic in the study of random constraint satisfaction problems (CSPs) is the geometry of the space of satisfying or almost satisfying assignments as the function of the density, for which a precise landscape of predictions has been…

Data Structures and Algorithms · Computer Science 2021-06-25 Jun-Ting Hsieh , Sidhanth Mohanty , Jeff Xu

The Constraint Satisfaction Problem (CSP) is ubiquitous in various areas of mathematics and computer science. Many of its variations have been studied including the Counting CSP, where the goal is to find the number of solutions to a CSP…

Computational Complexity · Computer Science 2025-01-24 Amirhossein Kazeminia , Andrei A. Bulatov

The constraint satisfaction problem asks to decide if a set of constraints over a relational structure $\mathcal{A}$ is satisfiable (CSP$(\mathcal{A})$). We consider CSP$(\mathcal{A} \cup \mathcal{B})$ where $\mathcal{A}$ is a structure and…

Computational Complexity · Computer Science 2024-08-28 Peter Jonsson , Victor Lagerkvist , George Osipov

Random constraint satisfaction problems (CSPs) have been widely studied both in AI and complexity theory. Empirically and theoretically, many random CSPs have been shown to exhibit a phase transition. As the ratio of constraints to…

Discrete Mathematics · Computer Science 2017-01-24 Colin Wei , Stefano Ermon

A new field of research is rapidly expanding at the crossroad between statistical physics, information theory and combinatorial optimization. In particular, the use of cutting edge statistical physics concepts and methods allow one to solve…

Neurons and Cognition · Quantitative Biology 2008-03-28 Marc Mezard , Thierry Mora

Constraint Satisfaction Problems (CSP) constitute a convenient way to capture many combinatorial problems. The general CSP is known to be NP-complete, but its complexity depends on a template, usually a set of relations, upon which they are…

Computational Complexity · Computer Science 2010-11-23 Florian Richoux

The regulation of the cell state is a complex process involving several components. These complex dynamics can be modeled using Boolean networks, allowing us to explain the existence of different cell states and the transition between them.…

Molecular Networks · Quantitative Biology 2010-01-28 Elke K. Markert , Nils Baas , Arnold J. Levine , Alexei Vazquez

Identity, response to external stimuli, and spatial architecture of a living system are central topics of molecular biology. Presently, they are largely seen as a result of the interplay between a gene repertoire and the regulatory…

Molecular Networks · Quantitative Biology 2007-05-23 M. Cosentino Lagomarsino , P. Jona , B. Bassetti

Chemical reaction network theory is a field of applied mathematics concerned with modeling chemical systems, and can be used in other contexts such as in systems biology to study cellular signaling pathways or epidemiology to study the…

Algebraic Geometry · Mathematics 2024-06-17 Maize Curiel , Elise Farr , Galileo Fries , Luis David García Puente , Julian Hutchins , Vuong Nguyen Hoang

Many AI synthesis problems such as planning or scheduling may be modelized as constraint satisfaction problems (CSP). A CSP is typically defined as the problem of finding any consistent labeling for a fixed set of variables satisfying all…

Artificial Intelligence · Computer Science 2013-03-25 Thomas Schiex

We define and study a statistical mechanics ensemble that characterizes connected solutions in constraint satisfaction problems (CSPs). Built around a well-known local entropy bias, it allows us to better identify hardness transitions in…

Disordered Systems and Neural Networks · Physics 2026-04-17 Damien Barbier

Random instances of Constraint Satisfaction Problems (CSP's) appear to be hard for all known algorithms, when the number of constraints per variable lies in a certain interval. Contributing to the general understanding of the structure of…

Discrete Mathematics · Computer Science 2009-04-20 Andrea Montanari , Ricardo Restrepo , Prasad Tetali

The analysis of the structure of chemical reaction networks is crucial for a better understanding of chemical processes. Such networks are well described as hypergraphs. However, due to the available methods, analyses regarding network…

Computational Complexity · Computer Science 2013-09-30 Rolf Fagerberg , Christoph Flamm , Daniel Merkle , Philipp Peters , Peter F. Stadler

Flux analysis is a class of constraint-based approaches to the study of biochemical reaction networks: they are based on determining the reaction flux configurations compatible with given stoichiometric and thermodynamic constraints. One of…

Molecular Networks · Quantitative Biology 2015-05-18 A. De Martino , E. Marinari

The constraint satisfaction problem (CSP) is a general problem central to computer science and artificial intelligence. Although the CSP is NP-hard in general, considerable effort has been spent on identifying tractable subclasses. The main…

Artificial Intelligence · Computer Science 2014-07-09 David A. Cohen , Martin C. Cooper , Páidí Creed , András Z. Salamon

Constraint satisfaction problems (CSPs) are a class of problems that are ubiquitous in science and engineering. It features a collection of constraints specified over subsets of variables. A CSP can be solved either directly or by reducing…

Computational Physics · Physics 2025-01-03 Xuanzhao Gao , Xiaofeng Li , Jinguo Liu
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