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Silicon nanochannel field effect transistor (FET) biosensors are one of the most promising technologies in the development of highly sensitive and label-free analyte detection for cancer diagnostics. With their exceptional electrical…

Quantitative Methods · Quantitative Biology 2014-01-07 Pritiraj Mohanty , Yu Chen , Xihua Wang , Mi K. Hong , Carol L. Rosenberg , David T. Weaver , Shyamsunder Erramilli

Despite being extremely old concepts, plasmonics and surface plasmon resonance-based biosensors have been increasingly popular in the recent two decades due to the growing interest in nanooptics and are now of relevant significance in…

Optics · Physics 2023-04-19 Giuseppina Simone

The interaction-free measurement is a fundamental quantum effect whereby the presence of a photosensitive object is determined without irreversible photon absorption. Here we propose the concept of coherent interaction-free detection and…

Quantum Physics · Physics 2023-07-10 Shruti Dogra , John J. McCord , Gheorghe Sorin Paraoanu

We investigate the possibility of using dielectric microdisk resonators for the optical detection of single atoms trapped and cooled in magnetic microtraps near the surface of a substrate. The bound and evanescent fields of optical…

Quantum Physics · Physics 2009-11-10 Michael Rosenblit , Peter Horak , Steve Helsby , Ron Folman

Ultrasensitive optical detection of nanometer-scaled particles is highly desirable for applications in early-stage diagnosis of human diseases, environmental monitoring, and homeland security, but remains extremely difficult due to ultralow…

Highly prolate-shaped whispering-gallery-mode "bottle microresonators" have recently attracted considerable attention due to their advantageous properties. We experimentally show that such resonators offer ultra-high quality factors,…

Optics · Physics 2011-05-03 D. O'Shea , C. Junge , S. Nickel , M. Poellinger , A. Rauschenbeutel

Lensless on-chip microscopy has shown great potential for biomedical imaging due to its large-area and high-throughput imaging capabilities. By combining the pixel super-resolution (PSR) technique, it can improve the resolution beyond the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-06 Xuyang Chang , Shaowei Jiang , Yongcun Hu , Liheng Bian

Mid-infrared absorption spectroscopy is a well-established technique for non-destructive quantitative molecular analysis. Waveguide-integrated sensors provide a particularly compact solution operating with reduced sample volumes while…

Identification of non-amplified DNA sequences and single-base mutations is essential for molecular biology and genetic diagnostics. This paper reports a novel sensor consisting of electrochemically-gated graphene coplanar waveguides coupled…

The negatively-charged NV$^-$-center in diamond has shown great success in nanoscale, high-sensitivity magnetometry. Efficient fluorescence detection is crucial for improving the sensitivity. Furthermore, integrated devices enable…

Highly sensitive and selective label free devices for real-time identification of specific biomarkers are expected to significantly impact the biosensing field. The ability of plasmonic systems to confine the light in nanometer volume and…

A multimode microcavity sensor based on a self-interference microring resonator is demonstrated experimentally. The proposed multimode sensing method is implemented by recording wideband transmission spectra that consist of multiple…

Linear super-resolution microscopy via synthesis aperture approach permits fast acquisition because of its wide-field implementations, however, it has been limited in resolution because a missing spatial-frequency band occurs when trying to…

A dielectric-modulated double gate bilayer electrodes organic thin-film transistor (DMDGBE-OTFT) based sensor is proposed for label-free biomolecule detection. The double gate of DMDGBE-OTFT is used for creating two symmetrical gates…

Instrumentation and Detectors · Physics 2022-05-31 Sushil Kumar Jain , Amit M. Joshi

Ultrahigh repetition rate lasers will become vital light sources for many future technologies; however, their realization is challenging because the cavity size must be minimized. Whispering-gallery-mode (WGM) microresonators are attractive…

The development of next generation medicines demand more sensitive and reliable label free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of…

Applied Physics · Physics 2019-05-22 Serena Rollo , Dipti Rani , Renaud Leturcq , Wouter Olthuis , César Pascual García

Scatterer induced modal coupling and the consequent mode splitting in a whispering gallery mode resonator is demonstrated in aqueous environment. The rate of change in splitting as particles enter the resonator mode volume strongly depends…

Optics · Physics 2010-11-05 Woosung Kim , Sahin Kaya Ozdemir , Jiangang Zhu , Lina He , Lan Yang

Label-free biosensors enable the monitoring of biomolecular interactions in real-time, which is key to the analysis of the binding characteristics of biomolecules. While refractometric optical biosensors are sensitive and well-established,…

This paper introduces a perspective approach for simulating a memristive sensor tailored for low power biological analyte detection. The necessity for such innovation stems from the increasing demand for efficient biosensing technologies…

Applied Physics · Physics 2024-08-13 Manel Bouzouita , Fakhreddine Zayer , Hamdi Belgacem

Integrated photonic circuits are foundational for versatile applications, where high-performance traveling-wave optical resonators are critical. Conventional whispering-gallery mode microresonators (WGMRs) confine light in closed-loop…