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Mutation rate is a key determinant of the pace as well as outcome of evolution, and variability in this rate has been shown in different scenarios to play a key role in evolutionary adaptation and resistance evolution under stress caused by…

Populations and Evolution · Quantitative Biology 2019-03-01 Dalit Engelhardt , Eugene I. Shakhnovich

In many biological processes, the size of a population changes stochastically with time, and recent work in the context of cancer and bacterial growth have focused on the situation when the mean population size grows exponentially. Here,…

Populations and Evolution · Quantitative Biology 2025-08-27 Kavita Jain , Hitesh Sumuni

Whether or not cooperation is favored in evolutionary games on graphs depends on the population structure and spatial properties of the interaction network. Population structures can be expressed as configurations. Such configurations…

Populations and Evolution · Quantitative Biology 2019-03-21 Hendrik Richter

We consider a spatial (line) model for invasion of a population by a single mutant with a stochastically selectively neutral fitness landscape, independent from the fitness landscape for non-mutants. This model is similar to those…

Probability · Mathematics 2021-04-05 Suzan Farhang-Sardroodi , Natalia L. Komarova , Marcus Michelen , Robin Pemantle

Evolutionary dynamics on graphs can lead to many interesting and counterintuitive findings. We study the Moran process, a discrete time birth-death process, that describes the invasion of a mutant type into a population of wild-type…

Populations and Evolution · Quantitative Biology 2015-04-23 Laura Hindersin , Arne Traulsen

In evolutionary game dynamics, reproductive success increases with the performance in an evolutionary game. If strategy $A$ performs better than strategy $B$, strategy $A$ will spread in the population. Under stochastic dynamics, a single…

Populations and Evolution · Quantitative Biology 2009-03-06 Philipp M. Altrock , Arne Traulsen

The unwelcome evolution of malignancy during cancer progression emerges through a selection process in a complex heterogeneous population structure. In the present work, we investigate evolutionary dynamics in a phenotypically heterogeneous…

Populations and Evolution · Quantitative Biology 2018-02-07 Ali Mahdipour Shirayeh , Kamran Kaveh , Mohammad Kohandel , Siv Sivaloganathan

We study stochastic evolutionary game dynamics in a population of finite size. Individuals in the population are divided into two dynamically evolving groups. The structure of the population is formally described by a Wright-Fisher type…

Probability · Mathematics 2020-07-01 Timothy Chumley , Ozgur Aydogmus , Anastasios Matzavinos , Alexander Roitershtein

Population structure can have a significant effect on evolution. For some systems with sufficient symmetry, analytic results can be derived within the mathematical framework of evolutionary graph theory which relate to the outcome of the…

Populations and Evolution · Quantitative Biology 2019-03-11 Christopher E. Overton , Mark Broom , Christoforos Hadjichrysanthou , Kieran J. Sharkey

Competition between biological species in marine environments is affected by the motion of the surrounding fluid. An effective 2D compressibility can arise, for example, from the convergence and divergence of water masses at the depth at…

Populations and Evolution · Quantitative Biology 2019-01-24 Abigail Plummer , Roberto Benzi , David R. Nelson , Federico Toschi

We study large fluctuations in evolutionary games belonging to the coordination and anti-coordination classes. The dynamics of these games, modeling cooperation dilemmas, is characterized by a coexistence fixed point separating two…

Populations and Evolution · Quantitative Biology 2015-05-19 Michael Assaf , Mauro Mobilia

Evolutionary branching is analysed in a stochastic, individual-based population model under mutation and selection. In such models, the common assumption is that individual reproduction and life career are characterised by values of a…

Populations and Evolution · Quantitative Biology 2025-10-01 S. Sagitov , B. Mehlig , P. Jagers , V. Vatutin

We investigate the process of fixation of advantageous mutations in an asexual population. We assume that the effect of each beneficial mutation is exponentially distributed with mean value $\omega_{med}=1/\beta$. The model also considers…

Populations and Evolution · Quantitative Biology 2009-11-10 Viviane M. de Oliveira , Paulo R. A. Campos

Bacteria evolve in volatile environments and complex spatial structures. Migration, fluctuations and environmental variability therefore have a significant impact on the evolution of microbial populations. Here, we consider a class of…

Populations and Evolution · Quantitative Biology 2025-11-24 Matthew Asker , Mohamed Swailem , Uwe C. Täuber , Mauro Mobilia

The stage of evolution is the population of reproducing individuals. The structure of the population is know to affect the dynamics and outcome of evolutionary processes, but analytical results for generic random structures have been…

Populations and Evolution · Quantitative Biology 2014-07-10 Ben Adlam , Martin A. Nowak

Evolution is a dynamic process. The two classical forces of evolution are mutation and selection. Assuming small mutation rates, evolution can be predicted based solely on the fitness differences between phenotypes. Predicting an…

Populations and Evolution · Quantitative Biology 2015-03-23 Benedikt Bauer , Chaitanya S. Gokhale

Linked beneficial and deleterious mutations are known to decrease the fixation probability of a favorable mutation in large asexual populations. While the hindering effect of strongly deleterious mutations on adaptive evolution has been…

Populations and Evolution · Quantitative Biology 2022-03-22 Kavita Jain

Dispersal of species to find a more favorable habitat is important in population dynamics. Dispersal rates evolve in response to the relative success of different dispersal strategies. In a simplified deterministic treatment (J. Dockery, V.…

Populations and Evolution · Quantitative Biology 2009-07-28 David A. Kessler , Leonard M. Sander

Natural microbial populations often have complex spatial structures. This can impact their evolution, in particular the ability of mutants to take over. While mutant fixation probabilities are known to be unaffected by sufficiently…

Populations and Evolution · Quantitative Biology 2024-12-30 Alia Abbara , Anne-Florence Bitbol

The accumulation of beneficial mutations on many competing genetic backgrounds in rapidly adapting populations has a striking impact on evolutionary dynamics. This effect, known as clonal interference, causes erratic fluctuations in the…

Populations and Evolution · Quantitative Biology 2013-05-31 Katya Kosheleva , Michael Desai