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We present the first two-dimensional (2D) optical Thomson scattering measurements of electron density and temperature in laser-produced plasmas. The novel instrument directly measures $n_e(x,y)$ and $T_e(x,y)$ in two dimensions over large…

Instrumentation and Detectors · Physics 2023-09-12 H. Zhang , J. J. Pilgram , C. G. Constantin , L. Rovige , P. V. Heuer , S. Ghazaryan , M. Kaloyan , R. S. Dorst , D. B. Schaeffer , C. Niemann

Avalanche photodiodes used for greenhouse gas sensing often use a mesa-structure that suffers from high surface leakage currents and edge breakdown. In this paper, we report 2-micron InGaAs/GaAsSb superlattice (SL) based planar PIN diodes…

Objective. The objective of the presented study was to evaluate the feasibility of a coded-mask (CM) gamma camera for real-time range verification in proton therapy, addressing the need for a precise and efficient method of treatment…

Objective: Real-time adaptive proton range verification systems based on produced neutrons require accurate information on their non-isotropic momentum distributions within short times, for which Monte Carlo (MC) methods are too…

Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…

Machine Learning · Computer Science 2021-09-10 Oscar Pastor-Serrano , Zoltán Perkó

Efficient coupling of intense laser pulses to solid-density matter is critical to many applications including ion acceleration for cancer therapy. At relativistic intensities, the focus has been mainly on investigating various laser beams…

Plasma Physics · Physics 2015-09-24 L. L. Ji , J. Snyder , A. Pukhov , R. R. Freeman , K. U. Akli

Droplet-based microfluidics systems have become widely used in recent years thanks to their advantages, varying from the possibility of handling small fluid volumes to directly synthesizing and encapsulating various living forms for…

The development of detectors that provide high resolution in four dimensions has attracted wide-spread interest in the scientific community for several applications in high-energy physics, nuclear physics, medical imaging, mass spectroscopy…

Purpose: Highlight the distinctions, both in terms of concept and numerical values, of the various definitions that can be established for the dose rate in PBS proton therapy. Methods: In an in silico study, five definitions of the dose…

Medical Physics · Physics 2023-07-17 Sylvain Deffet , Valentin Hamaide , Edmond Sterpin

We have demonstrated the feasibility of performing high-frame-rate, fast neutron radiography of air-water two-phase flows in a thin channel with rectangular cross section. The experiments have been carried out at the accelerator facility of…

Instrumentation and Detectors · Physics 2015-04-09 R. Zboray , I. Mor , V. Dangendorf , M. Stark , K. Tittelmeier , M. Cortesi , R. Adams

A multilayer gaseous detector has been developed for the fast dose-verification measurements of raster-scan-mode therapeutic beams in particle therapy.

Instrumentation and Detectors · Physics 2015-06-05 Kyong Sei Lee , Sung Hwan Ahn , Youngyih Han , Byungsik Hong , Minho Kang , Sang Yeol Kim , Seunkyung Lee , Sung Keun Park

The interplay between the beam delivery time structure and the patient motion makes 4D dose calculation (4DDC) important when treating moving tumors with intensity modulated proton therapy. 4DDC based on phase sorting of a 4DCT suffers from…

Medical Physics · Physics 2023-10-13 Ivar Bengtsson , Erik Engwall , Albin Fredriksson , Lars Glimelius

Charged Particle Therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbons. A critical issue is the monitoring of the dose released by the beam to the tumor and to the surrounding tissues. We present…

We present a comprehensive study on the effects of proton irradiation at different energies (150 and 590 keV) with the fluence of 1x 1012 proton/cm2 on monolayer MoS2. This study not only improves our understanding of the influence of…

We propose the BayesDose-Framework, a Bayesian approach for fast and accurate dose prediction in proton therapy. Our framework is based on a previously published deterministic LSTM model and is trained and evaluated on simulated beamlet…

Medical Physics · Physics 2023-07-04 Luke Voss , Ahmad Neishabouri , Tim Ortkamp , Andrea Mairani , Niklas Wahl

We are currently conceiving, through (MC) simulation, a multi-channel gamma detector array (TIARA for Time-of-flight Imaging ARrAy) for the online monitoring of protontherapy treatments. By measuring the Time-Of-Flight (TOF) between a beam…

We propose an innovative method for proton radiography based on nuclear emulsion film detectors, a technique in which images are obtained by measuring the position and the residual range of protons passing through the patient's body. For…

Instrumentation and Detectors · Physics 2014-11-20 S. Braccini , A. Ereditato , I. Kreslo , U. Moser , C. Pistillo , S. Studer , P. Scampoli , A. Coray , E. Pedroni

Plastic scintillation detectors are increasingly used to measure dose distributions in the context of radiotherapy treatments. Their water-equivalence, real-time response and high spatial resolution distinguish them from traditional…

Medical Physics · Physics 2021-09-22 Emily Cloutier , Louis Archambault , Luc Beaulieu

The Beam Dump Facility (BDF) is a planned fixed-target installation in CERN's North Area, set to start operating in 2031. A proton beam of 400 GeV/c will be delivered in 1 s pulses of 4e13 protons every 7.2 s, amounting to 4e19 protons on…

Range uncertainties in proton therapy hamper treatment precision. Prompt gamma-rays were suggested 16 years ago for real-time range verification, and have already shown promising results in clinical studies with collimated cameras.…

Medical Physics · Physics 2021-12-07 F. Hueso-González , T. Bortfeld