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Atherosclerotic plaque growth is characterised by chronic inflammation that promotes accumulation of cellular debris and extracellular fat in the inner artery wall. This material is highly thrombogenic, and plaque rupture can lead to the…
Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the…
Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to…
Atherosclerosis is a chronic inflammatory cardiovascular disease in which fatty plaque is built inside an artery wall. Early atherosclerotic plaque development is typically characterized by inflammatory tissues primarily consisting of foam…
Atherosclerosis, a chronic inflammatory cardiovascular disease, leads to arterial constriction caused by the accumulation of lipids, cholesterol, and various substances within artery walls. Such plaque can rupture, resulting in a blood clot…
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on size and on distribution. In order to understand this…
Atherosclerotic plaques are fatty growths in artery walls that cause heart attacks and strokes. Plaque formation is orchestrated by macrophages that are recruited to the artery wall to consume and remove blood-derived lipids, such as…
Smooth muscle cells (SMCs) play a fundamental role in the development of atherosclerotic plaques. They ingest lipids in a similar way to monocyte-derived macrophages (MDMs) in the plaque. This can stimulate SMCs to undergo a phenotypic…
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid.…
We extend the lipid-structured model for atherosclerotic plaque development of Ford et al. (2019) to account for macrophage proliferation. Proliferation is modelled as a non-local decrease in the lipid structural variable that is similar to…
As one of the most prevalent diseases worldwide, plaque formation in human arteries, known as atherosclerosis, is the focus of many research efforts. Previously, molecular communication (MC) models have been proposed to capture and analyze…
Analyses of individual atherosclerotic plaques are mostly descriptive, relying -- for example -- on histological classification by spectral analysis of ultrasound waves or staining and observing particular cellular components. Such passive…
Atherosclerosis, hardening of the arteries, originates from small plaque in the arteries; it is a major cause of disability and premature death in the United States and worldwide. In this paper, we study the bifurcation of a highly…
Atherosclerosis is a state wherein plaque (fat, cholesterol, and different substances) develops inside the veins that in the end prompts carotid artery stenosis which is a phase of narrowing in the huge courses situated on either side of…
Atherosclerotic plaques are accumulations of cholesterol-engorged macrophages in the artery wall. Plaque growth is initiated and sustained by the deposition of low density lipoproteins (LDL) in the artery wall. High density lipoproteins…
Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages (MDMs). The mechanisms that govern the spatial distribution…
When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…
Atherosclerosis, a chronic lesion of vascular wall, remains a leading cause of death and loss of life years. Classical hypotheses for atherosclerosis are long-standing mainly to explain atherogenesis. Unfortunately, these hypotheses may not…
Platelet adhesion and aggregation are essential for primary hemostasis, forming a clot that quickly stops initial bleeding. Despite this critical role, the dynamic interactions of platelet receptors with exposed collagen and von Willebrand…
The mechanisms by which organs acquire their functional structure and realize its maintenance (or homeostasis) over time are still largely unknown. In this paper, we investigate this question on adipose tissue. Adipose tissue can represent…