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An important goal of medical imaging is to be able to precisely detect patterns of disease specific to individual scans; however, this is challenged in brain imaging by the degree of heterogeneity of shape and appearance. Traditional…

Developing inherently interpretable models for prediction has gained prominence in recent years. A subclass of these models, wherein the interpretable network relies on learning high-level concepts, are valued because of closeness of…

Computer Vision and Pattern Recognition · Computer Science 2025-03-20 Jayneel Parekh , Quentin Bouniot , Pavlo Mozharovskyi , Alasdair Newson , Florence d'Alché-Buc

Background: Brain maturation and aging involve significant microstructural changes, resulting in functional and cognitive alterations. Quantitative MRI (qMRI) can measure this evolution, distinguishing the physiological effects of normal…

Dynamic functional connectivity analysis provides valuable information for understanding brain functional activity underlying different cognitive processes. Besides sliding window based approaches, a variety of methods have been developed…

Computer Vision and Pattern Recognition · Computer Science 2018-09-18 Hongming Li , Yong Fan

Standard neuroimaging techniques provide non-invasive access not only to human brain anatomy but also to its physiology. The activity recorded with these techniques is generally called functional imaging, but what is observed per se is an…

Neurons and Cognition · Quantitative Biology 2019-02-25 David Papo

Improving the interpretability of brain decoding approaches is of primary interest in many neuroimaging studies. Despite extensive studies of this type, at present, there is no formal definition for interpretability of brain decoding…

Machine Learning · Statistics 2016-06-21 Seyed Mostafa Kia , Andrea Passerini

We address the problem of single photo age progression and regression-the prediction of how a person might look in the future, or how they looked in the past. Most existing aging methods are limited to changing the texture, overlooking…

Computer Vision and Pattern Recognition · Computer Science 2020-07-27 Roy Or-El , Soumyadip Sengupta , Ohad Fried , Eli Shechtman , Ira Kemelmacher-Shlizerman

In neuroscience, functional brain connectivity describes the connectivity between brain regions that share functional properties. Neuroscientists often characterize it by a time series of covariance matrices between functional measurements…

Methodology · Statistics 2019-07-09 Zhenhua Lin , Dehan Kong , Qiang Sun

In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

Neurons and Cognition · Quantitative Biology 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

The ability to record activities from hundreds of neurons simultaneously in the brain has placed an increasing demand for developing appropriate statistical techniques to analyze such data. Recently, deep generative models have been…

Machine Learning · Statistics 2020-11-11 Ding Zhou , Xue-Xin Wei

Brain function emerges from coordinated activity across anatomically connected regions, where structural connectivity (SC) -- the network of white matter pathways - provides the physical substrate for functional connectivity (FC) -- the…

Neurons and Cognition · Quantitative Biology 2025-07-09 Sam Frank Kelemen , Joaquín Gõni , Sérgio Pequito , Arian Ashourvan

Recent developments in network neuroscience have highlighted the importance of developing techniques for analyzing and modeling brain networks. A particularly powerful approach for studying complex neural systems is to formulate generative…

Neurons and Cognition · Quantitative Biology 2022-09-09 Viplove Arora , Enrico Amico , Joaquín Goñi , Mario Ventresca

This study introduces a novel method for predicting cognitive age using psychophysiological tests. To determine cognitive age, subjects were asked to complete a series of psychological tests measuring various cognitive functions, including…

Neurons and Cognition · Quantitative Biology 2025-12-29 Daria D. Tyurina , Sergey V. Stasenko , Konstantin V. Lushnikov , Maria V. Vedunova

The brain structural connectome is generated by a collection of white matter fiber bundles constructed from diffusion weighted MRI (dMRI), acting as highways for neural activity. There has been abundant interest in studying how the…

Methodology · Statistics 2022-11-03 Didong Li , Phuc Nguyen , Zhengwu Zhang , David B Dunson

Deep Learning for neuroimaging data is a promising but challenging direction. The high dimensionality of 3D MRI scans makes this endeavor compute and data-intensive. Most conventional 3D neuroimaging methods use 3D-CNN-based architectures…

Image and Video Processing · Electrical Eng. & Systems 2021-02-10 Umang Gupta , Pradeep K. Lam , Greg Ver Steeg , Paul M. Thompson

Structural and appearance changes in brain imaging over time are crucial indicators of neurodevelopment and neurodegeneration. The rapid advancement of large-scale generative models provides a promising backbone for modeling these complex…

Graphics · Computer Science 2025-03-14 Gexin Huang , Zhangsihao Yang , Yalin Wang , Guido Gerig , Mengwei Ren , Xiaoxiao Li

Large Language Models (LLMs) have demonstrated strong semantic reasoning across multimodal domains. However, their integration with graph-based models of brain connectivity remains limited. In addition, most existing fMRI analysis methods…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Yasaman Torabi , Parsa Razmara , Hamed Ajorlou , Bardia Baraeinejad

Multimodal neuroimaging modeling has becomes a widely used approach but confronts considerable challenges due to heterogeneity, which encompasses variability in data types, scales, and formats across modalities. This variability…

Neurons and Cognition · Quantitative Biology 2025-04-15 Gang Qu , Ziyu Zhou , Vince D. Calhoun , Aiying Zhang , Yu-Ping Wang

Brain gender differences have been known for a long time and are the possible reason for many psychological, psychiatric and behavioral differences between males and females. Predicting genders from brain functional connectivity (FC) can…

Image and Video Processing · Electrical Eng. & Systems 2020-05-19 Gengyan Zhao , Gyujoon Hwang , Cole J. Cook , Fang Liu , Mary E. Meyerand , Rasmus M. Birn

A central challenge in the computational modeling of neural dynamics is the trade-off between accuracy and simplicity. At the level of individual neurons, nonlinear dynamics are both experimentally established and essential for neuronal…