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Motif discovery in DNA sequences is a challenging task in molecular biology. In computational motif discovery, Planted (l, d) motif finding is a widely studied problem and numerous algorithms are available to solve it. Both hardware and…

Computational Engineering, Finance, and Science · Computer Science 2014-03-07 P. Perera , R. G. Ragel

Genomics is changing our understanding of humans, evolution, diseases, and medicines to name but a few. As sequencing technology is developed collecting DNA sequences takes less time thereby generating more genetic data every day. Today the…

Quantitative Methods · Quantitative Biology 2020-07-29 Sahand Salamat , Tajana Rosing

Binarized Neural Networks (BNNs) significantly reduce the computation and memory demands with binarized weights and activations compared to full-precision NNs. Executing a layer in a BNN on different devices of a heterogeneous…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-13 Leonard David Bereholschi , Ching-Chi Lin , Mikail Yayla , Jian-Jia Chen

Many evolutionary algorithms (EAs) take advantage of parallel evaluation of candidates. However, if evaluation times vary significantly, many worker nodes (i.e.,\ compute clients) are idle much of the time, waiting for the next generation…

Neural and Evolutionary Computing · Computer Science 2024-01-02 Jason Liang , Hormoz Shahrzad , Risto Miikkulainen

The searching procedure of neural architecture search (NAS) is notoriously time consuming and cost prohibitive.To make the search space continuous, most existing gradient-based NAS methods relax the categorical choice of a particular…

Computer Vision and Pattern Recognition · Computer Science 2019-12-11 Shoufa Chen , Yunpeng Chen , Shuicheng Yan , Jiashi Feng

Modeling long sequences is crucial for various large-scale models; however, extending existing architectures to handle longer sequences presents significant technical and resource challenges. In this paper, we propose an efficient and…

Computation and Language · Computer Science 2024-10-08 Ning Wang , Zekun Li , Tongxin Bai , Guoqi Li

Deep convolution Neural Network (DCNN) has been widely used in computer vision tasks. However, for edge devices even inference has too large computational complexity and data access amount. The inference latency of state-of-the-art models…

Hardware Architecture · Computer Science 2025-09-09 Kuan-Ting Lin , Ching-Te Chiu , Jheng-Yi Chang , Shi-Zong Huang , Yu-Ting Li

We introduce FFN Fusion, an architectural optimization technique that reduces sequential computation in large language models by identifying and exploiting natural opportunities for parallelization. Our key insight is that sequences of…

Modern societies have developed insatiable demands for more computation capabilities. Exploiting implicit parallelism to provide automatic performance improvement remains a central goal in engineering future general-purpose computing…

Hardware Architecture · Computer Science 2018-12-14 Sushant Kondguli , Michael Huang

De novo assembly enables investigations of unknown genomes, paving the way for personalized medicine and disease management. However, it faces immense computational challenges arising from the excessive data volumes and algorithmic…

Hardware Architecture · Computer Science 2025-05-14 Heewoo Kim , Sanjay Sri Vallabh Singapuram , Haojie Ye , Joseph Izraelevitz , Trevor Mudge , Ronald Dreslinski , Nishil Talati

The ability to perform pixel-wise semantic segmentation in real-time is of paramount importance in mobile applications. Recent deep neural networks aimed at this task have the disadvantage of requiring a large number of floating point…

Computer Vision and Pattern Recognition · Computer Science 2016-06-08 Adam Paszke , Abhishek Chaurasia , Sangpil Kim , Eugenio Culurciello

We present MaxMem, a tiered main memory management system that aims to maximize Big Data application colocation and performance. MaxMem uses an application-agnostic and lightweight memory occupancy control mechanism based on fast memory…

Operating Systems · Computer Science 2023-12-04 Amanda Raybuck , Wei Zhang , Kayvan Mansoorshahi , Aditya K. Kamath , Mattan Erez , Simon Peter

Recent nano-technological advances enable the Monolithic 3D (M3D) integration of multiple memory and logic layers in a single chip, allowing for fine-grained connections between layers and significantly alleviating main memory bottlenecks.…

We propose EMMA, an efficient and unified architecture for multimodal understanding, generation and editing. Specifically, EMMA primarily consists of 1) An efficient autoencoder with a 32x compression ratio, which significantly reduces the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-16 Xin He , Longhui Wei , Jianbo Ouyang , Minghui Liao , Lingxi Xie , Qi Tian

Bit-serial computation facilitates bit-wise sequential data processing, offering numerous benefits, such as a reduced area footprint and dynamically-adaptive computational precision. It has emerged as a prominent approach, particularly in…

Systems and Control · Electrical Eng. & Systems 2025-07-17 Man Shi , Vikram Jain , Antony Joseph , Maurice Meijer , Marian Verhelst

Genome sequencing has become a central focus in computational biology. A genome study typically begins with sequencing, which produces millions to billions of short DNA fragments known as reads. Read mapping aligns these reads to a…

B-spline based orbital representations are widely used in Quantum Monte Carlo (QMC) simulations of solids, historically taking as much as 50% of the total run time. Random accesses to a large four-dimensional array make it challenging to…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-08-10 Amrita Mathuriya , Ye Luo , Anouar Benali , Luke Shulenburger , Jeongnim Kim

The effectiveness of deep neural networks (DNN) in vision, speech, and language processing has prompted a tremendous demand for energy-efficient high-performance DNN inference systems. Due to the increasing memory intensity of most DNN…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-10-15 Skanda Koppula , Lois Orosa , Abdullah Giray Yağlıkçı , Roknoddin Azizi , Taha Shahroodi , Konstantinos Kanellopoulos , Onur Mutlu

Quantization is a critical technique for accelerating LLM inference by reducing memory footprint and improving computational efficiency. Among various schemes, 4-bit weight and 8-bit activation quantization (W4A8) offers a strong balance…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Huanqi Hu , Bowen Xiao , Shixuan Sun , Jianian Yin , Zhexi Zhang , Xiang Luo , Chengquan Jiang , Weiqi Xu , Xiaoying Jia , Xin Liu , Minyi Guo

Representation learning is an important step in the machine learning pipeline. Given the current biological sequencing data volume, learning an explicit representation is prohibitive due to the dimensionality of the resulting feature…

Machine Learning · Computer Science 2023-04-04 Sarwan Ali , Usama Sardar , Murray Patterson , Imdad Ullah Khan
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