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To understand biological intelligence we need to map neuronal networks in vertebrate brains. Mapping mesoscale neural circuitry is done using injections of tracers that label groups of neurons whose axons project to different brain regions.…

Neurons and Cognition · Quantitative Biology 2025-05-13 Samik Banerjee , Caleb Stam , Daniel J. Tward , Steven Savoia , Yusu Wang , Partha P. Mitra

In physics we often use very simple models to describe systems with many degrees of freedom, but it is not clear why or how this success can be transferred to the more complex biological context. We consider models for the joint…

Neurons and Cognition · Quantitative Biology 2024-12-06 Luisa Ramirez , William Bialek , Stephanie E. Palmer , David J. Schwab

This paper introduces a hierarchical clustering algorithm, the Clustroid Hierarchical Nearest Neighbor ($\mathrm{CHN}^2$), designed for datasets with a countably infinite number of points. The method builds clusters across successive levels…

Probability · Mathematics 2025-11-17 Sayeh Khaniha , François Baccelli

Deep learning has led to significant advances in artificial intelligence, in part, by adopting strategies motivated by neurophysiology. However, it is unclear whether deep learning could occur in the real brain. Here, we show that a deep…

Neurons and Cognition · Quantitative Biology 2017-04-11 Jordan Guergiuev , Timothy P. Lillicrap , Blake A. Richards

We analytically study the input-output properties of a neuron whose active dendritic tree, modeled as a Cayley tree of excitable elements, is subjected to Poisson stimulus. Both single-site and two-site mean-field approximations incorrectly…

Neurons and Cognition · Quantitative Biology 2012-01-18 Leonardo L. Gollo , Osame Kinouchi , Mauro Copelli

The precise timing of spikes emitted by neurons plays a crucial role in shaping the response of efferent biological neurons. This temporal dimension of neural activity holds significant importance in understanding information processing in…

Neurons and Cognition · Quantitative Biology 2023-07-27 Antoine Grimaldi , Laurent U Perrinet

Much of the information processing performed by a neuron occurs in the dendritic tree. For neural systems using light for communication, it is advantageous to convert signals to the electronic domain at synaptic terminals so dendritic…

Neural and Evolutionary Computing · Computer Science 2019-04-08 Jeffrey M. Shainline

Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional and structural…

In the intricate architecture of the mammalian central nervous system, neurons form populations. Axonal bundles communicate between these clusters using spike trains. However, these neuron populations' precise encoding and operations have…

Neurons and Cognition · Quantitative Biology 2024-01-02 Martin N. P. Nilsson

Making an informed, correct and quick decision can be life-saving. It's crucial for animals during an escape behaviour or for autonomous cars during driving. The decision can be complex and may involve an assessment of the amount of threats…

Neural and Evolutionary Computing · Computer Science 2018-11-19 Hannes Rapp , Martin Paul Nawrot , Merav Stern

We introduce the notion of intensity reweighted moment pseudostationary point processes on linear networks. Based on arbitrary general regular linear network distances, we propose geometrically corrected versions of different higher-order…

Methodology · Statistics 2019-10-09 Ottmar Cronie , Mehdi Moradi , Jorge Mateu

We present a continuous model for structural brain connectivity based on the Poisson point process. The model treats each streamline curve in a tractography as an observed event in connectome space, here a product space of cortical white…

Neurons and Cognition · Quantitative Biology 2018-11-07 Daniel Moyer , Boris A. Gutman , Joshua Faskowitz , Neda Jahanshad , Paul M. Thompson

We consider a class of point processes (pp), which we call {\em sub-Poisson}; these are pp that can be directionally-convexly ($dcx$) dominated by some Poisson pp. The $dcx$ order has already been shown useful in comparing various point…

Probability · Mathematics 2012-12-05 Bartlomiej Blaszczyszyn , D. Yogeshwaran

Gibbs point processes (GPPs) constitute a large and flexible class of spatial point processes with explicit dependence between the points. They can model attractive as well as repulsive point patterns. Feature selection procedures are an…

Statistics Theory · Mathematics 2021-01-22 Ismaïla Ba , Jean-François Coeurjolly

Learning the latent network structure from large scale multivariate point process data is an important task in a wide range of scientific and business applications. For instance, we might wish to estimate the neuronal functional…

Methodology · Statistics 2021-01-21 Biao Cai , Jingfei Zhang , Yongtao Guan

Spatial stochastic models have been much used for performance analysis of wireless communication networks. This is due to the fact that the performance of wireless networks depends on the spatial configuration of wireless nodes and the…

Information Theory · Computer Science 2016-06-10 Naoto Miyoshi , Tomoyuki Shirai

We develop a phenomenological coarse--graining procedure for activity in a large network of neurons, and apply this to recordings from a population of 1000+ cells in the hippocampus. Distributions of coarse--grained variables seem to…

Neurons and Cognition · Quantitative Biology 2019-10-30 Leenoy Meshulam , Jeffrey L. Gauthier , Carlos D. Brody , David W. Tank , William Bialek

Recent experiments revealed that a certain class of inhibitory neurons in the cerebral cortex make synapses not onto cell bodies but at distal parts of dendrites of the target neurons, mediating highly nonlinear dendritic inhibition. We…

Neurons and Cognition · Quantitative Biology 2007-05-23 Kenji Morita , Kazuyuki Aihara

We model the spatial dynamics of a forest stand by using a special class of spatio-temporal point processes, the sequential spatial point process, where the spatial dimension is parameterized and the time component is atomic. The sequential…

The brain as a neuronal system has very complex structure with large diversity of neuronal types. The most basic complexity is seen from the structure of neuronal morphology, which usually has a complex tree-like structure with dendritic…

Neurons and Cognition · Quantitative Biology 2019-05-08 Lingling An , Yuanhong Tang , Quan Wang , Qingqi Pei , Ran Wei , Huiyuan Duan , Jian K. Liu