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This work describes a hyperbolic model for cell-cell repulsion with population dynamics. We consider the pressure produced by a population of cells to describe their motion. We assume that cells try to avoid crowded areas and prefer locally…

Analysis of PDEs · Mathematics 2024-05-24 Quentin Griette , Pierre Magal , Min Zhao

We discuss several continuum cell-cell adhesion models based on the underlying microscopic assumptions. We propose an improvement on these models leading to sharp fronts and intermingling invasion fronts between different cell type…

Cell Behavior · Quantitative Biology 2019-01-11 Jose A. Carrillo , Hideki Murakawa , Makoto Sato , Hideru Togashi , Olena Trush

This study presents a computational simulation exploring the complex interactions between population density and economic factors over a 100-year period. Inspired by the Keller-Segel model, traditionally applied in biological contexts, my…

Physics and Society · Physics 2024-01-03 Richard Murdoch Montgomery

We investigate the large time behavior of an agent based model describing tumor growth. The microscopic model combines short-range repulsion and cell division. As the number of cells increases exponentially in time, the microscopic model is…

Soft Condensed Matter · Physics 2017-01-04 Sebastien Motsch , Diane Peurichard

In this work we describe a hyperbolic model with cell-cell repulsion with a dynamics in the population of cells. More precisely, we consider a population of cells producing a field (which we call "pressure") which induces a motion of the…

Analysis of PDEs · Mathematics 2020-09-09 Xiaoming Fu , Quentin Griette , Pierre Magal

The spreading of bacterial populations is central to processes in agriculture, the environment, and medicine. However, existing models of spreading typically focus on cells in unconfined settings--despite the fact that many bacteria inhabit…

Populations and Evolution · Quantitative Biology 2022-06-07 Daniel B. Amchin , Jenna A. Ott , Tapomoy Bhattacharjee , Sujit S. Datta

We are concerned with the hyperbolic Keller-Segel model with quorum sensing, a model describing the collective cell movement due to chemical signalling with a flux limitation for high cell densities. This is a first order quasilinear…

Analysis of PDEs · Mathematics 2007-05-23 Benoit Perthame , Anne-Laure Dalibard

The Keller-Segel model is a system of partial differential equations modelling chemotactic aggregation in cellular systems. This model has blowing up solutions for large enough initial conditions in dimensions d >= 2, but all the solutions…

Analysis of PDEs · Mathematics 2009-11-11 Carlos Escudero

We investigate the dynamics of a colony of crawling, proliferating cells with a minimal, mechanical cell model. The cells consist of two disks, modelling the cell body and a pseudopod, connected by a finite extensible spring. The cells…

Cell Behavior · Quantitative Biology 2019-04-11 Simon K. Schnyder , John J. Molina , Ryoichi Yamamoto

The effect of mechanical interactions between cells in the spreading of bacterial populations was investigated in one-dimensional space. A continuum-mechanics approach, comprising cell migration, proliferation, and exclusion processes, was…

Biological Physics · Physics 2015-12-15 Waipot Ngamsaad , Suthep Suantai

Models of tissue growth are now well established, in particular in relation to their applications to cancer. They describe the dynamics of cells subject to motion resulting from a pressure gradient generated by the death and birth of cells,…

Analysis of PDEs · Mathematics 2018-09-07 Piotr Gwiazda , Benoît Perthame , Agnieszka Świerczewska-Gwiazda

We present a novel mathematical model of heterogeneous cell proliferation where the total population consists of a subpopulation of slow-proliferating cells and a subpopulation of fast-proliferating cells. The model incorporates two…

Cell Behavior · Quantitative Biology 2021-11-04 Sean T. Vittadello , Scott W. McCue , Gency Gunasingh , Nikolas K. Haass , Matthew J. Simpson

The Keller-Segel model is a system of partial differential equations that describes the movement of cells or organisms in response to chemical signals, a phenomenon known as chemotaxis. In this study, we analyze a doubly parabolic…

Analysis of PDEs · Mathematics 2025-03-27 Anne Caroline Bronzi , Crystianne Lilian de Andrade

We investigate the one-dimensional Keller-Segel model where the diffusion is replaced by a non-local operator, namely the fractional diffusion with exponent $0<\alpha\leq 2$. We prove some features related to the classical two-dimensional…

Analysis of PDEs · Mathematics 2015-05-13 Nikolaos Bournaveas , Vincent Calvez

We study a new nonlocal approach to the mathematical modelling of the Chemotaxis problem, which describes the random motion of a certain population due a substance concentration. Considering the initial-boundary value problem for the…

Analysis of PDEs · Mathematics 2022-06-03 Gerardo Huaroto , Wladimir Neves

A novel trait-structured Keller-Segel model that explores the dynamics of a migrating cell population guided by chemotaxis in response to an external ligand concentration is derived and analysed. Unlike traditional Keller-Segel models, this…

Cell Behavior · Quantitative Biology 2025-02-27 Viktoria Freingruber , Tommaso Lorenzi , Kevin J. Painter , Mariya Ptashnyk

Simulations are performed according to the Axelrod model of culture dissemination, with modified mechanism of repulsion. Previously, repulsion was considered by Radillo-Diaz et al (Phys. Rev. E 80 (2009) 066107) as dependent on a predefined…

Physics and Society · Physics 2023-07-19 M. J. Krawczyk , K. Kulakowski

In most biological studies and processes, cell proliferation and population dynamics play an essential role. Due to this ubiquity, a multitude of mathematical models has been developed to describe these processes. While the simplest models…

Populations and Evolution · Quantitative Biology 2012-02-23 J. Hasenauer , D. Schittler , F. Allgower

A parabolic-parabolic (Patlak-) Keller-Segel model in up to three space dimensions with nonlinear cell diffusion and an additional nonlinear cross-diffusion term is analyzed. The main feature of this model is that there exists a new entropy…

Analysis of PDEs · Mathematics 2011-10-18 José Antonio Carrillo , Sabine Hittmeir , Ansgar Jüngel

How can repulsive and attractive forces, acting on a conservative system, create stable traveling patterns or branching instabilities? We have proposed to study this question in the framework of the hyperbolic Keller-Segel system with…

Pattern Formation and Solitons · Physics 2015-05-20 Benoit Perthame , Christian Schmeiser , Min Tang , Nicolas Vauchelet
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