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We consider a diffuse interface model for tumour growth consisting of a Cahn--Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the…

Analysis of PDEs · Mathematics 2016-05-26 Harald Garcke , Kei Fong Lam

We study the optimal control problem of a free boundary PDE model describing the growth of multilayered tumor tissue in vitro. We seek the optimal amount of tumor growth inhibitor that simultaneously minimizes the thickness of the tumor…

Analysis of PDEs · Mathematics 2024-10-21 Xinyue Evelyn Zhao , Yixiang Wu , Rachel Leander , Wandi Ding , Suzanne Lenhart

This paper is devoted to an optimal control problem of fully coupled forward-backward stochastic differential equations driven by sub-diffusion, whose solutions are not Markov processes. The stochastic maximum principle is obtained, where…

Optimization and Control · Mathematics 2025-03-11 Chenhui Hao , Jingtao Shi , Shuaiqi Zhang

In this work, we consider a diffuse interface model for tumour growth in the presence of a nutrient which is consumed by the tumour. The system of equations consists of a Cahn--Hilliard equation with source terms for the tumour cells and a…

Numerical Analysis · Mathematics 2022-05-09 Harald Garcke , Dennis Trautwein

We investigate the exact enlarged controllability and optimal control of a fractional diffusion equation in Caputo sense. This is done through a new definition of enlarged controllability that allows us to extend available contributions.…

Optimization and Control · Mathematics 2020-03-31 Touria Karite , Ali Boutoulout , Delfim F. M. Torres

We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…

Optimization and Control · Mathematics 2017-07-24 Christian Kahle , Kei Fong Lam

In this paper we study the optimal control of an initial-boundary value problem for the classical nonviscous Cahn-Hilliard system with zero Neumann boundary conditions. Phase field systems of this type govern the evolution of diffusive…

Optimization and Control · Mathematics 2024-06-12 Pierluigi Colli , Jürgen Sprekels

We consider a diffuse interface model of tumor growth proposed by A.~Hawkins-Daruud et al. This model consists of the Cahn-Hilliard equation for the tumor cell fraction $\varphi$ nonlinearly coupled with a reaction-diffusion equation for…

Analysis of PDEs · Mathematics 2014-12-05 Sergio Frigeri , Maurizio Grasselli , Elisabetta Rocca

This paper is concerned with the concepts of regional controllability for the Riemann-Liouville time fractional diffusion systems of order $\alpha\in(0,1)$. The characterizations of strategic actuators to achieve regional controllability…

Optimization and Control · Mathematics 2016-08-09 Fudong Ge , YangQuan Chen , Chunhai Kou

In this paper, we explore the solvability and the optimal control problem for a compartmental model based on reaction-diffusion partial differential equations describing a transmissible disease. The nonlinear model takes into account the…

Optimization and Control · Mathematics 2023-08-25 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

Analysis of PDEs · Mathematics 2025-10-09 Giulia Cavalleri

This paper is to investigate the control problem of maximizing the net benefit of a single species while the cost of the resource allocation is minimized in a population model which can be described by a reaction diffusion advection…

Optimization and Control · Mathematics 2019-01-01 Lianzhang Bao , Huilai Li , Haojian Liang , Guangliang Zhao

In this paper, we study an optimal control problem for a coupled non-linear system of reaction-diffusion equations with degenerate diffusion, consisting of two partial differential equations representing the density of cells and the…

Optimization and Control · Mathematics 2024-07-11 Georges Chamoun , Mazen Saad , Toni Sayah , Sarah Serhal

In this paper we study the optimal control of a parabolic initial-boundary value problem of viscous Cahn-Hilliard type with zero Neumann boundary conditions. Phase field systems of this type govern the evolution of diffusive phase…

Optimization and Control · Mathematics 2024-09-20 Pierluigi Colli , Jürgen Sprekels , Fredi Tröltzsch

In this paper we study a distributed control problem for a phase field system of Caginalp type with logarithmic potential. The main aim of this work would be to force the location of the diffuse interface to be as close as possible to a…

Analysis of PDEs · Mathematics 2014-10-27 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi , Elisabetta Rocca

We consider a terminal control problem for processes governed by a nonlinear system of fractional ODEs. In order to show existence of the control, we first consider the linear counterpart of the system and reprove a number of classical…

Optimization and Control · Mathematics 2022-12-27 Maja Jolić , Sanja Konjik , Darko Mitrović

We study the boundary regional controllability of a class of Riemann-Liouville fractional semilinear sub-diffusion systems with boundary Neumann conditions. The result is obtained by using semi-group theory, the fractional Hilbert…

Optimization and Control · Mathematics 2024-01-19 Asmae Tajani , Fatima-Zahrae El Alaoui , Delfim F. M. Torres

Research focus on optimal control problems brought on by fractional differential equations has been extensively applied in practice. However, because they are still open-ended and challenging, a number of problems with fractional…

Populations and Evolution · Quantitative Biology 2023-04-25 Samuel Okyere , Joseph Ackora-Prah , Kwaku Forkuoh Darkwah , Francis Tabi Oduro , Ebenezer Bonyah

We consider the problem of finite-horizon optimal control of a discrete linear time-varying system subject to a stochastic disturbance and fully observable state. The initial state of the system is drawn from a known Gaussian distribution,…

Optimization and Control · Mathematics 2017-11-08 Maxim Goldshtein , Panagiotis Tsiotras

A distributed optimal control problem with final observation for a three- dimensional Lagrange averaged Navier-Stokes-? model is studied. The solvability of the optimal control problem is proved and the first-order optimality conditions are…

Optimization and Control · Mathematics 2013-10-23 Elder J. Villamizar-Roa , Elva Ortega-Torres
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