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The grade of clear cell renal cell carcinoma (ccRCC) is a critical prognostic factor, making ccRCC nuclei grading a crucial task in RCC pathology analysis. Computer-aided nuclei grading aims to improve pathologists' work efficiency while…

Image and Video Processing · Electrical Eng. & Systems 2021-06-22 Zeyu Gao , Jiangbo Shi , Xianli Zhang , Yang Li , Haichuan Zhang , Jialun Wu , Chunbao Wang , Deyu Meng , Chen Li

The need for labour intensive pixel-wise annotation is a major limitation of many fully supervised learning methods for segmenting bioimages that can contain numerous object instances with thin separations. In this paper, we introduce a…

Computer Vision and Pattern Recognition · Computer Science 2020-09-11 Rihuan Ke , Aurélie Bugeau , Nicolas Papadakis , Peter Schuetz , Carola-Bibiane Schönlieb

The recognition of multi-class cell nuclei can significantly facilitate the process of histopathological diagnosis. Numerous pathological datasets are currently available, but their annotations are inconsistent. Most existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-02-21 Junjia Huang , Haofeng Li , Xiang Wan , Guanbin Li

Machine learning has been widely adopted for medical image analysis in recent years given its promising performance in image segmentation and classification tasks. As a data-driven science, the success of machine learning, in particular…

Computer Vision and Pattern Recognition · Computer Science 2020-07-06 Chengliang Dai , Shuo Wang , Yuanhan Mo , Kaichen Zhou , Elsa Angelini , Yike Guo , Wenjia Bai

Deep learning based image segmentation has achieved the state-of-the-art performance in many medical applications such as lesion quantification, organ detection, etc. However, most of the methods rely on supervised learning, which require a…

Computer Vision and Pattern Recognition · Computer Science 2020-04-20 Ruizhe Li , Dorothee Auer , Christian Wagner , Xin Chen

Two of the most common tasks in medical imaging are classification and segmentation. Either task requires labeled data annotated by experts, which is scarce and expensive to collect. Annotating data for segmentation is generally considered…

Computer Vision and Pattern Recognition · Computer Science 2020-12-01 Ozan Ciga , Anne L. Martel

Segmentation and accurate localization of nuclei in histopathological images is a very challenging problem, with most existing approaches adopting a supervised strategy. These methods usually rely on manual annotations that require a lot of…

Image and Video Processing · Electrical Eng. & Systems 2020-07-17 Mihir Sahasrabudhe , Stergios Christodoulidis , Roberto Salgado , Stefan Michiels , Sherene Loi , Fabrice André , Nikos Paragios , Maria Vakalopoulou

Accurate cell segmentation in pathology images typically requires dense pixel-wise annotations, which are costly and time-consuming to obtain. This challenge is especially important for emerging biological imaging modalities and multiplexed…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Gunjan Shrivastava , Saad Nadeem

Accurate nuclei detection and classification are fundamental to computational pathology, yet existing approaches are hindered by reliance on detailed expert annotations and insufficient use of tissue context. We present Tissue-Aware Nuclei…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Kesi Xu , Eleni Chiou , Ali Varamesh , Laura Acqualagna , Nasir Rajpoot

We present a weakly supervised deep learning method to perform instance segmentation of cells present in microscopy images. Annotation of biomedical images in the lab can be scarce, incomplete, and inaccurate. This is of concern when…

Computer Vision and Pattern Recognition · Computer Science 2019-08-28 Fidel A. Guerrero-Peña , Pedro D. Marrero Fernandez , Tsang Ing Ren , Alexandre Cunha

Deep ConvNets have shown great performance for single-label image classification (e.g. ImageNet), but it is necessary to move beyond the single-label classification task because pictures of everyday life are inherently multi-label.…

Computer Vision and Pattern Recognition · Computer Science 2019-02-27 Thibaut Durand , Nazanin Mehrasa , Greg Mori

Polyp segmentation is a crucial step towards computer-aided diagnosis of colorectal cancer. However, most of the polyp segmentation methods require pixel-wise annotated datasets. Annotated datasets are tedious and time-consuming to produce,…

Computer Vision and Pattern Recognition · Computer Science 2022-11-23 Guangyu Ren , Michalis Lazarou , Jing Yuan , Tania Stathaki

High-resolution microscopy images of tissue specimens provide detailed information about the morphology of normal and diseased tissue. Image analysis of tissue morphology can help cancer researchers develop a better understanding of cancer…

Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Faisal Mahmood , Daniel Borders , Richard Chen , Gregory N. McKay , Kevan J. Salimian , Alexander Baras , Nicholas J. Durr

We propose a software platform that integrates methods and tools for multi-objective parameter auto- tuning in tissue image segmentation workflows. The goal of our work is to provide an approach for improving the accuracy of nucleus/cell…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-09 Luis F. R. Taveira , Tahsin Kurc , Alba C. M. A. Melo , Jun Kong , Erich Bremer , Joel H. Saltz , George Teodoro

Masked image modelling (MIM) is a powerful self-supervised representation learning paradigm, whose potential has not been widely demonstrated in medical image analysis. In this work, we show the capacity of MIM to capture rich semantic…

Computer Vision and Pattern Recognition · Computer Science 2023-06-30 Piotr Wójcik , Hussein Naji , Adrian Simon , Reinhard Büttner , Katarzyna Bożek

Deep convolutional neural networks have shown outstanding performance in medical image segmentation tasks. The usual problem when training supervised deep learning methods is the lack of labeled data which is time-consuming and costly to…

Computer Vision and Pattern Recognition · Computer Science 2021-03-04 Suman Sedai , Bhavna Antony , Ravneet Rai , Katie Jones , Hiroshi Ishikawa , Joel Schuman , Wollstein Gadi , Rahil Garnavi

Nuclei instance segmentation is an essential task in pathology image analysis, serving as the foundation for many downstream applications. The release of several public datasets has significantly advanced research in this area, yet many…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Jiamu Wang , Jin Tae Kwak

In the last few years, deep learning classifiers have shown promising results in image-based medical diagnosis. However, interpreting the outputs of these models remains a challenge. In cancer diagnosis, interpretability can be achieved by…

Computer Vision and Pattern Recognition · Computer Science 2021-06-16 Kangning Liu , Yiqiu Shen , Nan Wu , Jakub Chłędowski , Carlos Fernandez-Granda , Krzysztof J. Geras

Pixel-wise segmentation is one of the most data and annotation hungry tasks in our field. Providing representative and accurate annotations is often mission-critical especially for challenging medical applications. In this paper, we propose…

Computer Vision and Pattern Recognition · Computer Science 2021-04-28 Simon Reiß , Constantin Seibold , Alexander Freytag , Erik Rodner , Rainer Stiefelhagen
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