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Related papers: Robust Nucleus Detection with Partially Labeled Ex…

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We propose a novel weakly supervised method to improve the boundary of the 3D segmented nuclei utilizing an over-segmented image. This is motivated by the observation that current state-of-the-art deep learning methods do not result in…

Computer Vision and Pattern Recognition · Computer Science 2021-08-31 S. Shailja , Jiaxiang Jiang , B. S. Manjunath

Convolutional neural networks (CNNs) have gained increasing popularity and versatility in recent decades, finding applications in diverse domains. These remarkable achievements are greatly attributed to the support of extensive datasets…

Computer Vision and Pattern Recognition · Computer Science 2024-07-26 Xin Zhang , Yuqi Song , Wyatt McCurdy , Xiaofeng Wang , Fei Zuo

Nuclear segmentation in histology images is a challenging task due to significant variations in the shape and appearance of nuclei. One of the main hurdles in nuclear instance segmentation is overlapping nuclei where a smart algorithm is…

Image and Video Processing · Electrical Eng. & Systems 2019-08-28 Navid Alemi Koohbanani , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Early detection of cancer can help improve patient prognosis by early intervention. Head and neck cancer is diagnosed in specialist centres after a surgical biopsy, however, there is a potential for these to be missed leading to delayed…

Computer Vision and Pattern Recognition · Computer Science 2024-05-08 Abdullah Alsalemi , Anza Shakeel , Mollie Clark , Syed Ali Khurram , Shan E Ahmed Raza

Automated detection and segmentation of pulmonary nodules on lung computed tomography (CT) scans can facilitate early lung cancer diagnosis. Existing supervised approaches for automated nodule segmentation on CT scans require voxel-based…

Computer Vision and Pattern Recognition · Computer Science 2018-02-26 Xinyang Feng , Jie Yang , Andrew F. Laine , Elsa D. Angelini

Large annotated datasets are vital for training segmentation models, but pixel-level labeling is time-consuming, error-prone, and often requires scarce expert annotators, especially in medical imaging. In contrast, coarse annotations are…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Le Zhang , Fuping Wu , Arun Thirunavukarasu , Kevin Bronik , Thomas Nichols , Bartlomiej W. Papiez

Classifying the various shapes and attributes of a glioma cell nucleus is crucial for diagnosis and understanding the disease. We investigate automated classification of glioma nuclear shapes and visual attributes using Convolutional Neural…

Computer Vision and Pattern Recognition · Computer Science 2017-01-11 Veda Murthy , Le Hou , Dimitris Samaras , Tahsin M. Kurc , Joel H. Saltz

Most of the current state-of-the-art methods for tumor segmentation are based on machine learning models trained on manually segmented images. This type of training data is particularly costly, as manual delineation of tumors is not only…

Computer Vision and Pattern Recognition · Computer Science 2019-08-21 Pawel Mlynarski , Hervé Delingette , Antonio Criminisi , Nicholas Ayache

Most computer vision research focuses on datasets containing thousands of images of commonplace objects. However, many high-impact datasets, such as those in medicine and the geosciences, contain fine-grain objects that require…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Indu Panigrahi , Ryan Manzuk , Adam Maloof , Ruth Fong

We propose a 3D convolutional neural network to simultaneously segment and detect cell nuclei in confocal microscopy images. Mirroring the co-dependency of these tasks, our proposed model consists of two serial components: the first part…

Image and Video Processing · Electrical Eng. & Systems 2018-09-07 Sundaresh Ram , Vicky T. Nguyen , Kirsten H. Limesand , Mert R. Sabuncu

Manually annotating nuclei from the gigapixel Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs) is a laborious and costly task, meaning automated algorithms for cell nuclei instance segmentation and classification could…

Computer Vision and Pattern Recognition · Computer Science 2024-07-29 João D. Nunes , Diana Montezuma , Domingos Oliveira , Tania Pereira , Jaime S. Cardoso

Segmentation in medical imaging is an essential and often preliminary task in the image processing chain, driving numerous efforts towards the design of robust segmentation algorithms. Supervised learning methods achieve excellent…

Image and Video Processing · Electrical Eng. & Systems 2024-04-03 Pierre Rougé , Pierre-Henri Conze , Nicolas Passat , Odyssée Merveille

Nuclei instance segmentation is critical in computational pathology for cancer diagnosis and prognosis. Recently, the Segment Anything Model has demonstrated exceptional performance in various segmentation tasks, leveraging its rich priors…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Jingze Su , Tianle Zhu , Jiaxin Cai , Zhiyi Wang , Qi Li , Xiao Zhang , Tong Tong , Shu Wang , Wenxi Liu

Nuclei appear small in size, yet, in real clinical practice, the global spatial information and correlation of the color or brightness contrast between nuclei and background, have been considered a crucial component for accurate nuclei…

Image and Video Processing · Electrical Eng. & Systems 2023-07-18 Zhenqi He , Mathias Unberath , Jing Ke , Yiqing Shen

Nuclei instance segmentation in pathological images is crucial for downstream tasks such as tumor microenvironment analysis. However, the high cost and scarcity of annotated data limit the applicability of fully supervised methods, while…

Computer Vision and Pattern Recognition · Computer Science 2025-10-13 Zenan Lin , Wei Li , Jintao Chen , Zihao Wu , Wenxiong Kang , Changxin Gao , Liansheng Wang , Jin-Gang Yu

Best performing nuclear segmentation methods are based on deep learning algorithms that require a large amount of annotated data. However, collecting annotations for nuclear segmentation is a very labor-intensive and time-consuming task.…

Quantitative Methods · Quantitative Biology 2019-09-10 Mostafa Jahanifar , Navid Alemi Koohbanani , Nasir Rajpoot

Annotating microscopy images for nuclei segmentation is laborious and time-consuming. To leverage the few existing annotations, also across multiple modalities, we propose a novel microscopy-style augmentation technique based on a…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Ye Liu , Sophia J. Wagner , Tingying Peng

In digital pathology, segmenting densely distributed objects like glands and nuclei is crucial for downstream analysis. Since detailed pixel-wise annotations are very time-consuming, we need semi-supervised segmentation methods that can…

Image and Video Processing · Electrical Eng. & Systems 2024-07-18 Meilong Xu , Xiaoling Hu , Saumya Gupta , Shahira Abousamra , Chao Chen

Semi-supervised segmentation methods have demonstrated promising results in natural scenarios, providing a solution to reduce dependency on manual annotation. However, these methods face significant challenges when directly applied to…

Computer Vision and Pattern Recognition · Computer Science 2024-02-08 Ye Zhang , Ziyue Wang , Yifeng Wang , Hao Bian , Linghan Cai , Hengrui Li , Lingbo Zhang , Yongbing Zhang

The usage of convolutional neural networks (CNNs) for unsupervised image segmentation was investigated in this study. In the proposed approach, label prediction and network parameter learning are alternately iterated to meet the following…

Computer Vision and Pattern Recognition · Computer Science 2020-08-26 Wonjik Kim , Asako Kanezaki , Masayuki Tanaka