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Berg and Purcell [Biophys. J. 20, 193 (1977)] calculated how the accuracy of concentration sensing by single-celled organisms is limited by noise from the small number of counted molecules. Here we generalize their results to the sensing of…

Molecular Networks · Quantitative Biology 2011-11-28 Thierry Mora , Ned S. Wingreen

We study modeling and identification of processes with a spectral density matrix of low rank. Equivalently, we consider processes having an innovation of reduced dimension for which Prediction Error Methods (PEM) algorithms are not directly…

Systems and Control · Electrical Eng. & Systems 2021-05-11 Giorgio Picci , Wenqi Cao , Anders Lindquist

In molecular communications, the direct detection of signaling molecules may be challenging due to a lack of suitable sensors and interference in the environment. Motivated by research in molecular biology, we investigate an indirect…

Information Theory · Computer Science 2022-04-25 Trang Ngoc Cao , Vahid Jamali , Wayan Wicke , Phee Lep Yeoh , Nikola Zlatanov , Jamie S Evans , Robert Schober

The ultimate detection limit of optical biosensors is often limited by various noise sources, including those introduced by the optical measurement setup. While sophisticated modifications to instrumentation may reduce noise, a simpler…

Signal Processing · Electrical Eng. & Systems 2021-09-07 Simon J. Ward , Rabeb Layouni , Sofia Arshavsky-Graham , Ester Segal , Sharon M. Weiss

Bayesian estimation is a powerful theoretical paradigm for the operation of quantum sensors. However, the Bayesian method for statistical inference generally suffers from demanding calibration requirements that have so far restricted its…

Quantum Physics · Physics 2021-09-22 Samuel P. Nolan , Augusto Smerzi , Luca Pezzè

Conventional multiparameter quantum sensing relies on joint estimation, but this approach faces two key limitations: theoretical bounds may be unattainable due to measurement incompatibility, and sensing may fail due to parameter…

Quantum Physics · Physics 2025-06-09 Chiranjib Mukhopadhyay , Abolfazl Bayat , Victor Montenegro , Matteo G. A. Paris

This paper studies the mitigation of intersymbol interference in a diffusive molecular communication system using enzymes that freely diffuse in the propagation environment. The enzymes form reaction intermediates with information molecules…

Information Theory · Computer Science 2014-01-21 Adam Noel , Karen C. Cheung , Robert Schober

Artificially engineered biosensors are highly inefficient in accurately measuring the concentration of biomarkers, particularly, during early diagnosis of diseases. On the other hand, single cellular systems such as chemotactic bacteria can…

Biological Physics · Physics 2019-07-12 Tuhin Chakrabortty , Manoj M Varma

Objective: The objective of the study is to efficiently increase the expressivity of surface electromyography-based (sEMG) gesture recognition systems. Approach: We use a problem transformation approach, in which actions were subset into…

We investigate the utility of different auxiliary objectives and training strategies within a neural sequence labeling approach to error detection in learner writing. Auxiliary costs provide the model with additional linguistic information,…

Computation and Language · Computer Science 2017-07-18 Marek Rei , Helen Yannakoudakis

Two-dimensional electronic spectroscopy provides information on coupling and energy transfer between excited states on ultrafast timescales. Only recently, incoherent fluorescence detection has made it possible to combine this method with…

Optics · Physics 2025-05-14 Sanchayeeta Jana , Simon Durst , Lucas Ludwig , Markus Lippitz

Noisy labels damage the performance of deep networks. For robust learning, a prominent two-stage pipeline alternates between eliminating possible incorrect labels and semi-supervised training. However, discarding part of noisy labels could…

Machine Learning · Computer Science 2023-01-09 Mingcai Chen , Hao Cheng , Yuntao Du , Ming Xu , Wenyu Jiang , Chongjun Wang

The kernel-based method has been successfully applied in linear system identification using stable kernel designs. From a Gaussian process perspective, it automatically provides probabilistic error bounds for the identified models from the…

Systems and Control · Electrical Eng. & Systems 2023-03-20 Mingzhou Yin , Roy S. Smith

In this paper, we propose and evaluate a novel algorithm for performing spectrum sensing on linear modulations based on second-order cyclic features of the received signals. The proposed approach has similar computational complexity to that…

Signal Processing · Electrical Eng. & Systems 2020-02-11 Anantha K. Karthik , Jameer Ali M. S , Mohammed Zafar Ali Khan , A. Bhagavathi Rao

Falsely annotated samples, also known as noisy labels, can significantly harm the performance of deep learning models. Two main approaches for learning with noisy labels are global noise estimation and data filtering. Global noise…

Machine Learning · Computer Science 2025-07-31 Yuval Grinberg , Nimrod Harel , Jacob Goldberger , Ofir Lindenbaum

Recent advances in Hierarchical Multi-label Classification (HMC), particularly neurosymbolic-based approaches, have demonstrated improved consistency and accuracy by enforcing constraints on a neural model during training. However, such…

Machine Learning · Computer Science 2025-12-29 Joshua Shay Kricheli , Khoa Vo , Aniruddha Datta , Spencer Ozgur , Paulo Shakarian

While a broad range of techniques have been proposed to tackle distribution shift, the simple baseline of training on an $\textit{undersampled}$ balanced dataset often achieves close to state-of-the-art-accuracy across several popular…

Machine Learning · Computer Science 2023-06-21 Niladri S. Chatterji , Saminul Haque , Tatsunori Hashimoto

Modularity plays a crucial role in the development and maintenance of complex systems. While end-to-end text spotting efficiently mitigates the issues of error accumulation and sub-optimal performance seen in traditional two-step…

Computer Vision and Pattern Recognition · Computer Science 2024-04-09 Mingxin Huang , Hongliang Li , Yuliang Liu , Xiang Bai , Lianwen Jin

Mixed linear regression involves the recovery of two (or more) unknown vectors from unlabeled linear measurements; that is, where each sample comes from exactly one of the vectors, but we do not know which one. It is a classic problem, and…

Machine Learning · Statistics 2014-02-10 Xinyang Yi , Constantine Caramanis , Sujay Sanghavi

Key enzymatic processes in biology use the nonequilibrium error correction mechanism called kinetic proofreading to enhance their specificity. Kinetic proofreading typically requires several dedicated structural features in the enzyme, such…

Molecular Networks · Quantitative Biology 2020-05-26 Vahe Galstyan , Kabir Husain , Fangzhou Xiao , Arvind Murugan , Rob Phillips