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Statistical machine learning algorithms have achieved state-of-the-art results on benchmark datasets, outperforming humans in many tasks. However, the out-of-distribution data and confounder, which have an unpredictable causal relationship,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-31 Changjie Lu

In causal machine learning, the fitting and evaluation of nuisance models are often performed on separate partitions, or folds, of the observed data. This technique, called cross-fitting, eliminates bias introduced by the use of black-box…

Methodology · Statistics 2026-05-12 Salvador V. Balkus , Hasan Laith , Nima S. Hejazi

Size of the training dataset is an important factor in the performance of a machine learning algorithms and tools used in medical image processing are not exceptions. Machine learning tools normally require a decent amount of training data…

Computer Vision and Pattern Recognition · Computer Science 2019-04-02 Amir Rastar

Medical image analysis is a vibrant research area that offers doctors and medical practitioners invaluable insight and the ability to accurately diagnose and monitor disease. Machine learning provides an additional boost for this area.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Athanasios Vlontzos , Daniel Rueckert , Bernhard Kainz

Our formal understanding of the inductive bias that drives the success of convolutional networks on computer vision tasks is limited. In particular, it is unclear what makes hypotheses spaces born from convolution and pooling operations so…

Neural and Evolutionary Computing · Computer Science 2017-04-19 Nadav Cohen , Amnon Shashua

Many studies in biomedical and health sciences involve small sample sizes due to logistic or financial constraints. Often, identifying weak (but scientifically interesting) associations between a set of predictors and a response…

Methodology · Statistics 2017-09-05 Hao Henry Zhou , Yilin Zhang , Vamsi K. Ithapu , Sterling C. Johnson , Grace Wahba , Vikas Singh

Deep learning models have shown promising performance for cell nucleus segmentation in the field of pathology image analysis. However, training a robust model from multiple domains remains a great challenge for cell nucleus segmentation.…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Dawei Fan , Yifan Gao , Jiaming Yu , Yanping Chen , Wencheng Li , Chuancong Lin , Kaibin Li , Changcai Yang , Riqing Chen , Lifang Wei

Background: Data driven stratification of patients into biologically informed subtypes holds promise for precision neuropsychiatry, yet neuroimaging-based clustering methods often fail to generalize across cohorts. While algorithmic…

Machine Learning · Computer Science 2025-06-12 Yuetong Yu , Ruiyang Ge , Ilker Hacihaliloglu , Alexander Rauscher , Roger Tam , Sophia Frangou

The development of foundation models for brain MRI depends critically on the scale, diversity, and consistency of available data, yet systematic assessments of these factors remain scarce. In this study, we analyze 54 publicly accessible…

Computer Vision and Pattern Recognition · Computer Science 2025-10-24 Minh Sao Khue Luu , Margaret V. Benedichuk , Ekaterina I. Roppert , Roman M. Kenzhin , Bair N. Tuchinov

Machine learning model bias can arise from dataset composition: correlated sensitive features can distort the downstream classification model's decision boundary and lead to performance differences along these features. Existing de-biasing…

Computer Vision and Pattern Recognition · Computer Science 2025-01-22 Miao Zhang , Zee fryer , Ben Colman , Ali Shahriyari , Gaurav Bharaj

Conventional and deep learning-based methods have shown great potential in the medical imaging domain, as means for deriving diagnostic, prognostic, and predictive biomarkers, and by contributing to precision medicine. However, these…

The recent statistical theory of neural networks focuses on nonparametric denoising problems that treat randomness as additive noise. Variability in image classification datasets does, however, not originate from additive noise but from…

Statistics Theory · Mathematics 2025-08-19 Juntong Chen , Sophie Langer , Johannes Schmidt-Hieber

Functional neuroimaging can measure the brain?s response to an external stimulus. It is used to perform brain mapping: identifying from these observations the brain regions involved. This problem can be cast into a linear supervised…

Machine Learning · Computer Science 2012-07-03 Gael Varoquaux , Alexandre Gramfort , Bertrand Thirion

Gaussian blurring is a well-established method for image data augmentation: it may generate a large set of images from a small set of pictures for training and testing purposes for Artificial Intelligence (AI) applications. When we apply AI…

Neurons and Cognition · Quantitative Biology 2020-10-22 Laszlo Keresztes , Evelin Szogi , Balint Varga , Vince Grolmusz

Detecting and measuring confounding effects from data is a key challenge in causal inference. Existing methods frequently assume causal sufficiency, disregarding the presence of unobserved confounding variables. Causal sufficiency is both…

Artificial Intelligence · Computer Science 2024-09-27 Abbavaram Gowtham Reddy , Vineeth N Balasubramanian

Machine learning models achieve state-of-the-art performance on many supervised learning tasks. However, prior evidence suggests that these models may learn to rely on shortcut biases or spurious correlations (intuitively, correlations that…

Machine Learning · Computer Science 2021-08-31 Sindhu C. M. Gowda , Shalmali Joshi , Haoran Zhang , Marzyeh Ghassemi

Causal inference is made challenging by confounding, selection bias, and other complications. A common approach to addressing these difficulties is the inclusion of auxiliary data on the superpopulation of interest. Such data may measure a…

Methodology · Statistics 2024-04-16 Jaron J. R. Lee , AmirEmad Ghassami , Ilya Shpitser

Many neurological diseases are characterized by gradual deterioration of brain structure and function. Large longitudinal MRI datasets have revealed such deterioration, in part, by applying machine and deep learning to predict diagnosis. A…

Image and Video Processing · Electrical Eng. & Systems 2021-05-27 Jiahong Ouyang , Qingyu Zhao , Edith V Sullivan , Adolf Pfefferbaum , Susan F. Tapert , Ehsan Adeli , Kilian M Pohl

We address the problem of integrating data from multiple, possibly biased, observational and interventional studies, to eventually compute counterfactuals in structural causal models. We start from the case of a single observational dataset…

Methodology · Statistics 2023-08-01 Marco Zaffalon , Alessandro Antonucci , Rafael Cabañas , David Huber

Clinical machine learning applications are often plagued with confounders that can impact the generalizability and predictive performance of the learners. Confounding is especially problematic in remote digital health studies where the…