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Optical microscopy is an essential tool in biology and medicine. Imaging thin, yet non-flat objects in a single shot (without relying on more sophisticated sectioning setups) remains challenging as the shallow depth of field that comes with…

Image and Video Processing · Electrical Eng. & Systems 2020-10-14 Adrian Shajkofci , Michael Liebling

In multi-photon microscopy (MPM), a recent in-vivo fluorescence microscopy system, the task of image restoration can be decomposed into two interlinked inverse problems: firstly, the characterization of the Point Spread Function (PSF) and…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Julien Ajdenbaum , Emilie Chouzenoux , Claire Lefort , Ségolène Martin , Jean-Christophe Pesquet

The quality of microscopy images often suffers from optical aberrations. These aberrations and their associated point spread functions have to be quantitatively estimated to restore aberrated images. The recent state-of-the-art method…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Kira Vinogradova , Eugene W. Myers

We present a semi-blind, spatially-variant deconvolution technique aimed at optical microscopy that combines a local estimation step of the point spread function (PSF) and deconvolution using a spatially variant, regularized Richardson-Lucy…

Computer Vision and Pattern Recognition · Computer Science 2019-05-21 Adrian Shajkofci , Michael Liebling

Deep-learning (DL)-based image deconvolution (ID) has exhibited remarkable recovery performance, surpassing traditional linear methods. However, unlike traditional ID approaches that rely on analytical properties of the point spread…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Romario Gualdrón-Hurtado , Roman Jacome , Sergio Urrea , Henry Arguello , Luis Gonzalez

In the imaging process of an astronomical telescope, the deconvolution of its beam or Point Spread Function (PSF) is a crucial task. However, deconvolution presents a classical and challenging inverse computation problem. In scenarios where…

Instrumentation and Methods for Astrophysics · Physics 2024-03-05 Shulei Ni , Yisheng Qiu , Yunchun Chen , Zihao Song , Hao Chen , Xuejian Jiang , Huaxi Chen

Deconvolution is the most commonly used image processing method to remove the blur caused by the point-spread-function (PSF) in optical imaging systems. While this method has been successful in deblurring, it suffers from several…

Image and Video Processing · Electrical Eng. & Systems 2019-10-10 Huangxuan Zhao , Ziwen Ke , Ningbo Chen , Ke Li , Lidai Wang , Xiaojing Gong , Wei Zheng , Liang Song , Zhicheng Liu , Dong Liang , Chengbo Liu

Due to limited size and imperfect of the optical components in a spectrometer, aberration has inevitably been brought into two-dimensional multi-fiber spectrum image in LAMOST, which leads to obvious spacial variation of the point spread…

Instrumentation and Methods for Astrophysics · Physics 2020-10-28 Jiali Xu , Qian Yin , Ping Guo , Xin Zheng

Optical astronomical images are strongly affected by the point spread function (PSF) of the optical system and the atmosphere (seeing) which blurs the observed image. The amount of blurring depends both on the observed band, and on the…

Instrumentation and Methods for Astrophysics · Physics 2023-08-31 Hong Wang , Sreevarsha Sreejith , Yuewei Lin , Nesar Ramachandra , Anže Slosar , Shinjae Yoo

Very deep convolutional neural networks (CNNs) have been firmly established as the primary methods for many computer vision tasks. However, most state-of-the-art CNNs are large, which results in high inference latency. Recently, depth-wise…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Yihui He , Jianing Qian , Jianren Wang , Cindy X. Le , Congrui Hetang , Qi Lyu , Wenping Wang , Tianwei Yue

In this paper, we propose a novel design of image deblurring in the form of one-shot convolution filtering that can directly convolve with naturally blurred images for restoration. The problem of optical blurring is a common disadvantage to…

Image and Video Processing · Electrical Eng. & Systems 2019-07-22 Mahdi S. Hosseini , Konstantinos N. Plataniotis

Deconvolution microscopy has been extensively used to improve the resolution of the widefield fluorescent microscopy. Conventional approaches, which usually require the point spread function (PSF) measurement or blind estimation, are…

Machine Learning · Computer Science 2019-04-08 Sungjun Lim , Sang-Eun Lee , Sunghoe Chang , Jong Chul Ye

We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function (PSF) of a…

Recent developments in fluorescence microscopy allow capturing high-resolution 3D images over time for living model organisms. To be able to image even large specimens, techniques like multi-view light-sheet imaging record different…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Canyu Yang , Dennis Eschweiler , Johannes Stegmaier

Fluorescence microscopy has enabled a dramatic development in modern biology by visualizing biological organisms with micrometer scale resolution. However, due to the diffraction limit, sub-micron/nanometer features are difficult to…

Image and Video Processing · Electrical Eng. & Systems 2021-03-10 Varun Mannam , Yide Zhang , Xiaotong Yuan , Scott Howard

Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…

Deconvolution of large survey images with millions of galaxies requires to develop a new generation of methods which can take into account a space variant Point Spread Function (PSF) and have to be at the same time accurate and fast. We…

Instrumentation and Methods for Astrophysics · Physics 2020-09-16 Florent Sureau , Alexis Lechat , Jean-Luc Starck

During the image acquisition process, noise is usually added to the data mainly due to physical limitations of the acquisition sensor, and also regarding imprecisions during the data transmission and manipulation. In that sense, the…

Machine Learning · Computer Science 2021-01-20 Rafael G. Pires , Daniel F. S. Santos , Marcos C. S. Santana , Claudio F. G. Santos , Joao P. Papa

Ultrasound is widely used in medical diagnostics allowing for accessible and powerful imaging but suffers from resolution limitations due to diffraction and the finite aperture of the imaging system, which restricts diagnostic use. The…

Computer Vision and Pattern Recognition · Computer Science 2024-08-08 Felix Duelmer , Walter Simson , Mohammad Farid Azampour , Magdalena Wysocki , Angelos Karlas , Nassir Navab

Due to image blurring image deconvolution is often used for studying biological structures in fluorescence microscopy. Fluorescence microscopy image volumes inherently suffer from intensity inhomogeneity, blur, and are corrupted by various…

Computer Vision and Pattern Recognition · Computer Science 2019-07-15 Soonam Lee , Shuo Han , Paul Salama , Kenneth W. Dunn , Edward J. Delp
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