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Accurate medical image segmentation is crucial for diagnosis and analysis. However, the models without calibrated uncertainty estimates might lead to errors in downstream analysis and exhibit low levels of robustness. Estimating the…

Image and Video Processing · Electrical Eng. & Systems 2021-09-16 Yanwu Yang , Xutao Guo , Yiwei Pan , Pengcheng Shi , Haiyan Lv , Ting Ma

Since radiologists have different training and clinical experiences, they may provide various segmentation annotations for a lung nodule. Conventional studies choose a single annotation as the learning target by default, but they waste…

Image and Video Processing · Electrical Eng. & Systems 2022-06-08 Han Yang , Lu Shen , Mengke Zhang , Qiuli Wang

Collecting annotations from multiple independent sources could mitigate the impact of potential noises and biases from a single source, which is a common practice in medical image segmentation. Learning segmentation networks from…

Image and Video Processing · Electrical Eng. & Systems 2023-11-14 Yifeng Wang , Luyang Luo , Mingxiang Wu , Qiong Wang , Hao Chen

Objective: Accurate probability estimates are essential for the safe deployment of medical image segmentation models in clinical decision-making. However, modern deep segmentation networks are often poorly calibrated, a problem exacerbated…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Meritxell Riera-Marín , Javier García López , Júlia Rodríguez-Comas , Miguel A. González Ballester , Adrian Galdran

Segmentation tasks in medical imaging are inherently ambiguous: the boundary of a target structure is oftentimes unclear due to image quality and biological factors. As such, predicted segmentations from deep learning algorithms are…

Image and Video Processing · Electrical Eng. & Systems 2019-11-18 Katharina Hoebel , Ken Chang , Jay Patel , Praveer Singh , Jayashree Kalpathy-Cramer

Radiologists possess diverse training and clinical experiences, leading to variations in the segmentation annotations of lung nodules and resulting in segmentation uncertainty.Conventional methods typically select a single annotation as the…

Image and Video Processing · Electrical Eng. & Systems 2023-09-12 Han Yang , Qiuli Wang , Yue Zhang , Zhulin An , Chen Liu , Xiaohong Zhang , S. Kevin Zhou

Annotation ambiguity due to inherent data uncertainties such as blurred boundaries in medical scans and different observer expertise and preferences has become a major obstacle for training deep-learning based medical image segmentation…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Yicheng Wu , Xiangde Luo , Zhe Xu , Xiaoqing Guo , Lie Ju , Zongyuan Ge , Wenjun Liao , Jianfei Cai

Supporting model interpretability for complex phenomena where annotators can legitimately disagree, such as emotion recognition, is a challenging machine learning task. In this work, we show that explicitly quantifying the uncertainty in…

Machine Learning · Computer Science 2019-10-08 Asma Ghandeharioun , Brian Eoff , Brendan Jou , Rosalind W. Picard

Recent years have seen increasing use of supervised learning methods for segmentation tasks. However, the predictive performance of these algorithms depends on the quality of labels. This problem is particularly pertinent in the medical…

Computer Vision and Pattern Recognition · Computer Science 2020-10-26 Le Zhang , Ryutaro Tanno , Mou-Cheng Xu , Chen Jin , Joseph Jacob , Olga Ciccarelli , Frederik Barkhof , Daniel C. Alexander

Uncertainty estimation has been widely studied in medical image segmentation as a tool to provide reliability, particularly in deep learning approaches. However, previous methods generally lack effective supervision in uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yuzhu Li , An Sui , Fuping Wu , Xiahai Zhuang

The ability of deep learning to predict with uncertainty is recognized as key for its adoption in clinical routines. Moreover, performance gain has been enabled by modelling uncertainty according to empirical evidence. While previous work…

Computer Vision and Pattern Recognition · Computer Science 2021-02-09 Jiawei Yang , Yuan Liang , Yao Zhang , Weinan Song , Kun Wang , Lei He

The use of deep learning for medical imaging has seen tremendous growth in the research community. One reason for the slow uptake of these systems in the clinical setting is that they are complex, opaque and tend to fail silently. Outside…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Terrance DeVries , Graham W. Taylor

Many machine learning systems today are trained on large amounts of human-annotated data. Data annotation tasks that require a high level of competency make data acquisition expensive, while the resulting labels are often subjective,…

Machine Learning · Computer Science 2020-04-08 Emmanouil Antonios Platanios , Maruan Al-Shedivat , Eric Xing , Tom Mitchell

Building an accurate computer-aided diagnosis system based on data-driven approaches requires a large amount of high-quality labeled data. In medical imaging analysis, multiple expert annotators often produce subjective estimates about…

Computer Vision and Pattern Recognition · Computer Science 2022-03-22 Khiem H. Le , Tuan V. Tran , Hieu H. Pham , Hieu T. Nguyen , Tung T. Le , Ha Q. Nguyen

Image segmentation is a critical step in computational biomedical image analysis, typically evaluated using metrics like the Dice coefficient during training and validation. However, in clinical settings without manual annotations,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Sikha O K , Meritxell Riera-Marín , Adrian Galdran , Javier García Lopez , Julia Rodríguez-Comas , Gemma Piella , Miguel A. González Ballester

Many real-world vision problems suffer from inherent ambiguities. In clinical applications for example, it might not be clear from a CT scan alone which particular region is cancer tissue. Therefore a group of graders typically produces a…

Equipping predicted segmentation with calibrated uncertainty is essential for safety-critical applications. In this work, we focus on capturing the data-inherent uncertainty (aka aleatoric uncertainty) in segmentation, typically when…

Computer Vision and Pattern Recognition · Computer Science 2023-02-28 Zhitong Gao , Yucong Chen , Chuyu Zhang , Xuming He

Quantifying uncertainty in medical image segmentation applications is essential, as it is often connected to vital decision-making. Compelling attempts have been made in quantifying the uncertainty in image segmentation architectures, e.g.…

Computer Vision and Pattern Recognition · Computer Science 2021-08-06 M. M. A. Valiuddin , C. G. A. Viviers , R. J. G. van Sloun , P. H. N. de With , F. van der Sommen

Medical image segmentation modeling is a high-stakes task where understanding of uncertainty is crucial for addressing visual ambiguity. Prior work has developed segmentation models utilizing probabilistic or generative mechanisms to infer…

Computer Vision and Pattern Recognition · Computer Science 2025-06-13 Andre Ye , Quan Ze Chen , Amy Zhang

In this study, we explore in depth a few under-studied topics at the intersection of uncertainty estimation and segmentation. Prior work has shown that the quality of uncertainty estimates can be very sensitive to a range of variables. As…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Michael Smith , Frank P. Ferrie
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