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Pose Machines provide a sequential prediction framework for learning rich implicit spatial models. In this work we show a systematic design for how convolutional networks can be incorporated into the pose machine framework for learning…

Computer Vision and Pattern Recognition · Computer Science 2016-04-13 Shih-En Wei , Varun Ramakrishna , Takeo Kanade , Yaser Sheikh

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

This paper provides a review of past approaches to the use of deep-learning frameworks for the analysis of discrete irregular-patterned complex sequential datasets. A typical example of such a dataset is financial data where specific events…

Machine Learning · Computer Science 2020-07-23 Kudakwashe Dandajena , Isabella M. Venter , Mehrdad Ghaziasgar , Reg Dodds

Scene graph generation aims to produce structured representations for images, which requires to understand the relations between objects. Due to the continuous nature of deep neural networks, the prediction of scene graphs is divided into…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 Meng Wei , Chun Yuan , Xiaoyu Yue , Kuo Zhong

Proteins perform much of the work in living organisms, and consequently the development of efficient computational methods for protein representation is essential for advancing large-scale biological research. Most current approaches…

Quantitative Methods · Quantitative Biology 2023-06-09 Francesco Ceccarelli , Lorenzo Giusti , Sean B. Holden , Pietro Liò

Character-based neural models have recently proven very useful for many NLP tasks. However, there is a gap of sophistication between methods for learning representations of sentences and words. While most character models for learning…

Computation and Language · Computer Science 2018-10-31 Yingwei Xin , Ethan Hart , Vibhuti Mahajan , Jean-David Ruvini

Constrained sequential pattern mining aims at identifying frequent patterns on a sequential database of items while observing constraints defined over the item attributes. We introduce novel techniques for constraint-based sequential…

Machine Learning · Computer Science 2019-01-01 Amin Hosseininasab , Willem-Jan van Hoeve , Andre A. Cire

Protein Structure Predication from sequences of amino acid has gained a remarkable attention in recent years. Even though there are some prediction techniques addressing this problem, the approximate accuracy in predicting the protein…

Computational Engineering, Finance, and Science · Computer Science 2014-01-14 Pokkuluri Kiran Sree , Inamupudi Ramesh Babu , SSSN Usha Devi N

Motivation: DNA data is transcribed into single-stranded RNA, which folds into specific molecular structures. In this paper we pose the question to what extent sequence- and structure-information correlate. We view this correlation as…

Combinatorics · Mathematics 2016-08-23 Christopher Barrett , Fenix W. Huang , Christian M. Reidys

Sequence modeling is currently dominated by causal transformer architectures that use softmax self-attention. Although widely adopted, transformers require scaling memory and compute linearly during inference. A recent stream of work…

Machine-learning models that learn from data to predict how protein sequence encodes function are emerging as a useful protein engineering tool. However, when using these models to suggest new protein designs, one must deal with the vast…

Quantitative Methods · Quantitative Biology 2021-07-07 Brian L. Hie , Kevin K. Yang

Multiple Sequences Alignment (MSA) of biological sequences is a fundamental problem in computational biology due to its critical significance in wide ranging applications including haplotype reconstruction, sequence homology, phylogenetic…

Distributed, Parallel, and Cluster Computing · Computer Science 2009-05-13 Fahad Saeed , Ashfaq Khokhar

This paper addresses the task of set prediction using deep feed-forward neural networks. A set is a collection of elements which is invariant under permutation and the size of a set is not fixed in advance. Many real-world problems, such as…

Computer Vision and Pattern Recognition · Computer Science 2021-10-26 Hamid Rezatofighi , Tianyu Zhu , Roman Kaskman , Farbod T. Motlagh , Qinfeng Shi , Anton Milan , Daniel Cremers , Laura Leal-Taixé , Ian Reid

The multiple sequence alignment (MSA) of a protein family provides a wealth of information in terms of the conservation pattern of amino acid residues not only at each alignment site but also between distant sites. In order to statistically…

Biomolecules · Quantitative Biology 2016-04-27 Akira R. Kinjo

High-quality training datasets are crucial for the development of effective protein design models, but existing synthetic datasets often include unfavorable sequence-structure pairs, impairing generative model performance. We leverage…

Efficiently capturing the long-range patterns in sequential data sources salient to a given task -- such as classification and generative modeling -- poses a fundamental challenge. Popular approaches in the space tradeoff between the memory…

Machine Learning · Computer Science 2023-11-03 Jiaxin Shi , Ke Alexander Wang , Emily B. Fox

Protein interactions are important in a broad range of biological processes. Traditionally, computational methods have been developed to automatically predict protein interface from hand-crafted features. Recent approaches employ deep…

Machine Learning · Computer Science 2020-07-21 Yi Liu , Hao Yuan , Lei Cai , Shuiwang Ji

Increasingly, researchers have suggested the benefits of temporal analysis to improve our understanding of the learning process. Sequential pattern mining (SPM), as a pattern recognition technique, has the potential to reveal the temporal…

Machine Learning · Computer Science 2023-05-02 Yingbin Zhang , Luc Paquette

Medical image segmentation is a fundamental task for medical image analysis and surgical planning. In recent years, UNet-based networks have prevailed in the field of medical image segmentation. However, convolution-neural networks (CNNs)…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Xin You , Junjun He , Jie Yang , Yun Gu

The field of protein folding research has been greatly advanced by deep learning methods, with AlphaFold2 (AF2) demonstrating exceptional performance and atomic-level precision. As co-evolution is integral to protein structure prediction,…

Quantitative Methods · Quantitative Biology 2023-06-06 Le Zhang , Jiayang Chen , Tao Shen , Yu Li , Siqi Sun