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We introduce a path sampling method for the computation of rate constants for systems with a highly diffusive character. Based on the recently developed algorithm of transition interface sampling (TIS) this procedure increases the…

Statistical Mechanics · Physics 2009-11-10 Daniele Moroni , Peter G. Bolhuis , Titus S. van Erp

A method is formulated, based on combining self-consistent field theory with dynamically corrected transition state theory, for estimating the rates of adsorption and desorption of end-constrained chains (e.g. by crosslinks or…

Soft Condensed Matter · Physics 2015-02-23 Doros N. Theodorou , Georgios G. Vogiatzis , Georgios Kritikos

In a previous contribution, Phys. Rev. Lett 107, 230601 (2011), we have proposed a method to treat first order phase transitions at low temperatures. It describes arbitrary order parameter through an analytical expression $W$, which depends…

Statistical Mechanics · Physics 2015-06-12 Carlos. E. Fiore , M. G. E. da Luz

Transition path sampling (TPS) is a powerful technique for investigating rare transitions, especially when the mechanism is unknown and one does not have access to the reaction coordinate. Straightforward application of TPS does not…

Chemical Physics · Physics 2019-07-11 Z. Faidon Brotzakis , Peter G. Bolhuis

Predicting labels of nodes in a network, such as community memberships or demographic variables, is an important problem with applications in social and biological networks. A recently-discovered phase transition puts fundamental limits on…

Social and Information Networks · Computer Science 2014-11-20 Pan Zhang , Cristopher Moore , Lenka Zdeborová

This article proposes a new path planning method for addressing multi-level terrain situations. The proposed method includes innovations in three aspects: 1) the pre-processing of point cloud maps with a multi-level skip-list structure and…

Robotics · Computer Science 2025-05-01 Yujie Tang , Quan Li , Hao Geng , Yangmin Xie , Hang Shi , Yusheng Yang

This paper introduces a novel numerical approach to achieving smooth lane-change trajectories in autonomous driving scenarios. Our trajectory generation approach leverages particle swarm optimization (PSO) techniques, incorporating Neural…

Robotics · Computer Science 2024-02-05 Lin Song , David Isele , Naira Hovakimyan , Sangjae Bae

Motion planning is a key element of robotics since it empowers a robot to navigate autonomously. Particle Swarm Optimization is a simple, yet a very powerful optimization technique which has been effectively used in many complex…

Robotics · Computer Science 2020-08-25 M. Shahab Alam , M. Usman Rafique , M. Umer Khan

We consider the problem of sampling transition paths between two given metastable states of a molecular system, e.g. a folded and unfolded protein or products and reactants of a chemical reaction. Due to the existence of high energy…

Biomolecules · Quantitative Biology 2023-07-19 Lars Holdijk , Yuanqi Du , Ferry Hooft , Priyank Jaini , Bernd Ensing , Max Welling

Image analysis and machine learning algorithms operating on multi-gigapixel whole-slide images (WSIs) often process a large number of tiles (sub-images) and require aggregating predictions from the tiles in order to predict WSI-level…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Mohsin Bilal , Robert Jewsbury , Ruoyu Wang , Hammam M. AlGhamdi , Amina Asif , Mark Eastwood , Nasir Rajpoot

Developing deep learning models with strong adaptability to topological variations is of great practical significance for power flow analysis. To enhance model performance under variable system scales and improve robustness in branch power…

Machine Learning · Computer Science 2026-01-06 Yongzhe Li , Lin Guan , Zihan Cai , Zuxian Lin , Jiyu Huang , Liukai Chen

Understanding the dynamics of complex molecular processes is often linked to the study of infrequent transitions between long-lived stable states. The standard approach to the sampling of such rare events is to generate an ensemble of…

Computational Physics · Physics 2023-05-22 Sebastian Falkner , Alessandro Coretti , Salvatore Romano , Phillip Geissler , Christoph Dellago

PAWS is a tool to analyse the behaviour of weighted automata and conditional transition systems. At its core PAWS is based on a generic implementation of algorithms for checking language equivalence in weighted automata and bisimulation in…

Formal Languages and Automata Theory · Computer Science 2017-07-14 Barbara König , Sebastian Küpper , Christina Mika

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Enhanced sampling techniques have become an essential tool in computational chemistry and physics, where they are applied to sample activated processes that occur on a time scale that is inaccessible to conventional simulations. Despite…

Chemical Physics · Physics 2022-01-13 F. Giberti , G. A. Tribello , M. Ceriotti

Natural systems often exhibit chaotic behavior in their space-time evolution. Systems transiting between chaos and order manifest a potential to compute, as shown with cellular automata and artificial neural networks. We demonstrate that…

Computational Physics · Physics 2025-04-04 Tomáš Vantuch , Ivan Zelinka , Andrew Adamatzky , Norbert Marwan

Interest in equilibrium-based sampling methods has grown with recent advances in computational hardware and Markov state modeling (MSM) methods, yet outstanding questions remain that hinder widespread adoption. Namely, how do sampling…

Biomolecules · Quantitative Biology 2018-05-15 Maxwell I. Zimmerman , Justin R. Porter , Xianqiang Sun , Roseane R. Silva , Gregory R. Bowman

The recent rise of cryo-EM and X-ray high-throughput techniques is providing a wealth of new structures trapped in different conformations. Understanding how proteins transition between different conformers, and how they relate to each…

Biomolecules · Quantitative Biology 2018-03-20 Laura Orellana , Johan Gustavsson , Cathrine Bergh , Ozge Yoluk , Erik Lindahl

The explosion of data throughout the biomedical sciences provides unprecedented opportunities to learn about the dynamics of evolution and disease progression, but harnessing these large and diverse datasets remains challenging. Here, we…

Quantitative Methods · Quantitative Biology 2019-12-03 Sam F. Greenbury , Mauricio Barahona , Iain G. Johnston

We present a one-way shooting algorithm for transition path sampling that accepts every proposed trajectory, yet samples the correct transition path ensemble for systems with overdamped stochastic dynamics. The method is based on two key…

Computational Physics · Physics 2026-03-10 Magdalena Häupl , Sebastian Falkner , Peter G. Bolhuis , Christoph Dellago , Alessandro Coretti