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Real-time simulation of elastic structures is essential in many applications, from computer-guided surgical interventions to interactive design in mechanical engineering. The Finite Element Method is often used as the numerical method of…

Machine Learning · Computer Science 2021-09-21 Alban Odot , Ryadh Haferssas , Stéphane Cotin

This paper tackles the challenge of parameter calibration in stochastic models, particularly in scenarios where the likelihood function is unavailable in an analytical form. We introduce a gradient-based simulated parameter estimation…

Machine Learning · Statistics 2025-03-25 Zehao Li , Yijie Peng

Computational modeling of the brain has become a key part of understanding how the brain clears metabolic waste, but patient-specific modeling on a significant scale is still out of reach with current methods. We introduce a novel approach…

Quantitative Methods · Quantitative Biology 2025-06-12 Andreas Solheim , Geir Ringstand , Per Kristian Eide , Kent-Andre Mardal

The interaction of fibers in a viscous (Stokes) fluid plays a crucial role in industrial and biological processes, such as sedimentation, rheology, transport, cell division, and locomotion. Numerical simulations generally rely on slender…

Numerical Analysis · Mathematics 2024-03-12 Dhairya Malhotra , Alex Barnett

Particle methods play an important role in computational fluid dynamics, but they are among the most difficult to implement and solve. The most common method is smoothed particle hydrodynamics, which is suitable for problem settings that…

Fluid Dynamics · Physics 2025-08-26 Masato Shibukawa , Naoya Ozaki , Maximilien Berthet

In this paper, a novel isogeometric method for Biot's consolidation model is constructed and analyzed, using a four-field formulation where the unknown variables are the solid displacement, solid pressure, fluid flux, and fluid pressure.…

Numerical Analysis · Mathematics 2025-02-14 Hanyu Chu , Luca Franco Pavarino

A two-phase model and its application to wavefields numerical simulation are discussed in the context of modeling of compressible fluid flows in elastic porous media. The derivation of the model is based on a theory of thermodynamically…

Fluid Dynamics · Physics 2020-06-11 Evgeniy Romenski , Galina Reshetova , Ilya Peshkov , Michael Dumbser

The numerical tools to simulate the bidomain model in cardiac electrophysiology are constantly developing due to the great clinical interest and scientific advances in mathematical models and computational power. The bidomain model consists…

Numerical Analysis · Mathematics 2025-11-03 Gopika P B , Peter Bastian , Nagaiah Chamakuri

Biot's theory predicts the wave velocities of a saturated poroelastic granular medium from the elastic properties, density and geometry of its dry solid matrix and the pore fluid, neglecting the interaction between constituent particles and…

Geophysics · Physics 2019-05-01 Hongyang Cheng , Stefan Luding , Nicolás Rivas , Jens Harting , Vanessa Magnanimo

Nowadays, data-intensive applications are gaining popularity and, together with this trend, processing-in-memory (PIM)-based systems are being given more attention and have become more relevant. This paper describes an analytical modeling…

Hardware Architecture · Computer Science 2021-07-23 Ronny Ronen , Adi Eliahu , Orian Leitersdorf , Natan Peled , Kunal Korgaonkar , Anupam Chattopadhyay , Ben Perach , Shahar Kvatinsky

The brain is probably the most complex organ in the human body. To understand processes such as learning or healing after brain lesions, we need suitable tools for brain simulations. The Model of Structural Plasticity offers a solution to…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-01-26 Hannah Nöttgen , Fabian Czappa , Felix Wolf

Inter subject variability of the electrical conductivity of brain, skull and skin strongly limits the accuracy by which current sources underlying electro-encephalography (EEG) can be localized in the brain. This inter subject variability…

The generalized Biot-Brinkman equations describe the displacement, pressures and fluxes in an elastic medium permeated by multiple viscous fluid networks and can be used to study complex poromechanical interactions in geophysics, biophysics…

Numerical Analysis · Mathematics 2021-12-28 Q. Hong , J. Kraus , M. Kuchta , M. Lymbery , K. A. Mardal , M. E. Rognes

In this paper we derive a pore-scale model for permeable biofilm formation in a two-dimensional pore. The pore is divided in two phases: water and biofilm. The biofilm is assumed to consist of four components: water, extracellular polymeric…

This paper presents the potential of applying physics-informed neural networks for solving nonlinear multiphysics problems, which are essential to many fields such as biomedical engineering, earthquake prediction, and underground energy…

Computational Engineering, Finance, and Science · Computer Science 2020-07-01 Teeratorn Kadeethum , Thomas M Jorgensen , Hamidreza M Nick

This work considers the optimization of electrode positions in head imaging by electrical impedance tomography. The study is motivated by maximizing the sensitivity of electrode measurements to conductivity changes when monitoring the…

Numerical Analysis · Mathematics 2023-12-19 N. Hyvönen , A. Jääskeläinen , R. Maity , A. Vavilov

A deep latent variable model is a powerful method for capturing complex distributions. These models assume that underlying structures, but unobserved, are present within the data. In this dissertation, we explore high-dimensional problems…

Machine Learning · Computer Science 2024-06-13 Khuong Vo

In this paper, we consider the numerical solution of poroelasticity problems that are of Biot type and develop a general algorithm for solving coupled systems. We discuss the challenges associated with mechanics and flow problems in…

Numerical Analysis · Mathematics 2015-08-11 Donald L. Brown , Maria Vasilyeva

The development of biophysical models for clinical applications is rapidly advancing in the research community, thanks to their predictive nature and their ability to assist the interpretation of clinical data. However, high-resolution and…

In cryo-electron microscopy (EM), molecular structures are determined from large numbers of projection images of individual particles. To harness the full power of this single-molecule information, we use the Bayesian inference of EM…

Biomolecules · Quantitative Biology 2018-01-17 Pilar Cossio , David Rohr , Fabio Baruffa , Markus Rampp , Volker Lindenstruth , Gerhard Hummer