English
Related papers

Related papers: Evaluating Protein Transfer Learning with TAPE

200 papers

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

Self-supervised learning has emerged as a powerful way to pre-train generalizable machine learning models on large amounts of unlabeled data. It is particularly compelling in the music domain, where obtaining labeled data is time-consuming,…

Sound · Computer Science 2024-04-16 Gabriel Meseguer-Brocal , Dorian Desblancs , Romain Hennequin

We introduce a pioneering methodology for boosting large language models in the domain of protein representation learning. Our primary contribution lies in the refinement process for correlating the over-reliance on co-evolution knowledge,…

Artificial Intelligence · Computer Science 2024-12-05 Yaoyao Xu , Xinjian Zhao , Xiaozhuang Song , Benyou Wang , Tianshu Yu

Transfer learning has become crucial in computer vision tasks due to the vast availability of pre-trained deep learning models. However, selecting the optimal pre-trained model from a diverse pool for a specific downstream task remains a…

Computer Vision and Pattern Recognition · Computer Science 2023-08-30 Xiaotong Li , Zixuan Hu , Yixiao Ge , Ying Shan , Ling-Yu Duan

Self-supervised learning has transformed 2D computer vision by enabling models trained on large, unannotated datasets to provide versatile off-the-shelf features that perform similarly to models trained with labels. However, in 3D scene…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Pedro Hermosilla , Christian Stippel , Leon Sick

Although supervised deep learning has revolutionized speech and audio processing, it has necessitated the building of specialist models for individual tasks and application scenarios. It is likewise difficult to apply this to dialects and…

Semi-supervised learning is a setting in which one has labeled and unlabeled data available. In this survey we explore different types of theoretical results when one uses unlabeled data in classification and regression tasks. Most methods…

Machine Learning · Computer Science 2020-07-31 Alexander Mey , Marco Loog

Elucidating principles that underlie computation in neural networks is currently a major research topic of interest in neuroscience. Transfer Entropy (TE) is increasingly used as a tool to bridge the gap between network structure, function,…

Neurons and Cognition · Quantitative Biology 2017-06-08 Madhavun Candadai Vasu , Eduardo J. Izquierdo

Protein language models (pLMs) have recently gained significant attention for their ability to uncover relationships between sequence, structure, and function from evolutionary statistics, thereby accelerating therapeutic drug discovery.…

Machine Learning · Computer Science 2026-03-04 Darshan Patil , Pranshu Malviya , Mathieu Reymond , Quentin Fournier , Sarath Chandar

Proteins play essential roles in nature, from catalyzing biochemical reactions to binding specific targets. Advances in protein engineering have the potential to revolutionize biotechnology and healthcare by designing proteins with tailored…

Biomolecules · Quantitative Biology 2025-05-05 Hocheol Lim , Geon-Ho Lee , Kyoung Tai No

Semi-supervised learning (SSL) has achieved significant progress by leveraging both labeled data and unlabeled data. Existing SSL methods overlook a common real-world scenario when labeled data is extremely scarce, potentially as limited as…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Hezhao Liu , Yang Lu , Mengke Li , Yiqun Zhang , Shreyank N Gowda , Chen Gong , Hanzi Wang

Protein-Protein Interactions (PPIs) are fundamental in various biological processes and play a key role in life activities. The growing demand and cost of experimental PPI assays require computational methods for efficient PPI prediction.…

Machine Learning · Computer Science 2024-02-23 Lirong Wu , Yijun Tian , Yufei Huang , Siyuan Li , Haitao Lin , Nitesh V Chawla , Stan Z. Li

Data efficiency, or the ability to generalize from a few labeled data, remains a major challenge in deep learning. Semi-supervised learning has thrived in traditional recognition tasks alleviating the need for large amounts of labeled data,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 George Eskandar , Shuai Zhang , Mohamed Abdelsamad , Mark Youssef , Diandian Guo , Bin Yang

The success of deep learning methods in medical image segmentation tasks usually requires a large amount of labeled data. However, obtaining reliable annotations is expensive and time-consuming. Semi-supervised learning has attracted much…

Image and Video Processing · Electrical Eng. & Systems 2021-07-13 Yichi Zhang , Jicong Zhang

Mask-based pretraining has become a cornerstone of modern large-scale models across language, vision, and recently biology. Despite its empirical success, its role and limits in learning data representations have been unclear. In this work,…

Machine Learning · Computer Science 2025-09-29 Mingze Dong , Leda Wang , Yuval Kluger

Pretraining DNA language models (DNALMs) on the full human genome is resource-intensive, yet often considered necessary for strong downstream performance. Inspired by recent findings in NLP and long-context modeling, we explore an…

Genomics · Quantitative Biology 2025-06-24 Sohan Mupparapu , Parameswari Krishnamurthy , Ratish Puduppully

In semi-supervised representation learning frameworks, when the number of labelled data is very scarce, the quality and representativeness of these samples become increasingly important. Existing literature on semi-supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Shuvendu Roy , Ali Etemad

Through solving pretext tasks, self-supervised learning leverages unlabeled data to extract useful latent representations replacing traditional input features in the downstream task. In audio/speech signal processing, a wide range of…

Audio and Speech Processing · Electrical Eng. & Systems 2022-11-23 Salah Zaiem , Titouan Parcollet , Slim Essid , Abdel Heba

Active learning is an iterative labeling process that is used to obtain a small labeled subset, despite the absence of labeled data, thereby enabling to train a model for supervised tasks such as text classification. While active learning…

Computation and Language · Computer Science 2024-10-07 Christopher Schröder , Gerhard Heyer

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

Machine Learning · Computer Science 2023-01-04 Lirong Wu , Yufei Huang , Haitao Lin , Stan Z. Li