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Functional magnetic resonance imaging (fMRI) time series are known to exhibit long-range temporal dependencies that challenge traditional modeling approaches. In this study, we propose a novel computational pipeline to characterize and…

Applications · Statistics 2025-08-19 Yasaman Shahhosseini , Cédric Beaulac , Farouk S. Nathoo , Michelle F. Miranda

Purpose: Age biases have been identified as an essential factor in the diagnosis of ASD. The objective of this study was to compare the effect of different age groups in classifying ASD using morphological features (MF) and morphological…

Image and Video Processing · Electrical Eng. & Systems 2023-08-16 Gokul Manoj , Sandeep Singh Sengar , Jac Fredo Agastinose Ronickom

Brain age estimation is clinically important as it can provide valuable information in the context of neurodegenerative diseases such as Alzheimer's. Population graphs, which include multimodal imaging information of the subjects along with…

Statistical techniques are needed to analyse data structures with complex dependencies such that clinically useful information can be extracted. Individual-specific networks, which capture dependencies in complex biological systems, are…

Methodology · Statistics 2023-08-30 Mariella Gregorich , Sean L. Simpson , Georg Heinze

The difference between the chronological and biological brain age of a subject can be an important biomarker for neurodegenerative diseases, thus brain age estimation can be crucial in clinical settings. One way to incorporate multimodal…

Learning a similarity metric has gained much attention recently, where the goal is to learn a function that maps input patterns to a target space while preserving the semantic distance in the input space. While most related work focused on…

Computer Vision and Pattern Recognition · Computer Science 2019-05-03 Guixiang Ma , Nesreen K. Ahmed , Ted Willke , Dipanjan Sengupta , Michael W. Cole , Nicholas B. Turk-Browne , Philip S. Yu

In this study, we propose the use of persistent homology -- specifically Betti curves for brain age prediction and for distinguishing between healthy and pathological aging. The proposed framework is applied to 100 structural MRI scans from…

Neurons and Cognition · Quantitative Biology 2025-11-11 Debanjali Bhattacharya , Neelam Sinha

Effective connectivity can describe the causal patterns among brain regions. These patterns have the potential to reveal the pathological mechanism and promote early diagnosis and effective drug development for cognitive disease. However,…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Qiankun Zuo , Hao Tian , Chi-Man Pun , Hongfei Wang , Yudong Zhang , Jin Hong

Magnetic Resonance Imaging (MRI) of the fetal brain has become a key tool for studying brain development in vivo. Yet, its assessment remains challenging due to variability in brain maturation, imaging protocols, and uncertain estimates of…

Image and Video Processing · Electrical Eng. & Systems 2025-10-09 Johannes Tischer , Patric Kienast , Marlene Stümpflen , Gregor Kasprian , Georg Langs , Roxane Licandro

Brain responses related to working memory originate from distinct brain areas and oscillate at different frequencies. EEG signals with high temporal correlation can effectively capture these responses. Therefore, estimating the functional…

Machine Learning · Computer Science 2024-05-01 Harshini Gangapuram , Vidya Manian

Functional brain graphs are often characterized with separate graph-theoretic or spectral descriptors, overlooking how these properties covary and partially overlap across brains and conditions. We anticipate that dense, weighted functional…

Neurons and Cognition · Quantitative Biology 2025-11-07 Subati Abulikemu , Tiago Azevedo , Michail Mamalakis , John Suckling

Grokking-the phenomenon where validation accuracy of neural networks on modular addition of two integers rises long after training data has been memorized-has been characterized in previous works as producing sinusoidal input weight…

Machine Learning · Computer Science 2026-03-26 Anand Swaroop

The purpose of this paper is to infer a global (collective) model of time-varying responses of a set of nodes as a dynamic graph, where the individual time series are respectively observed at each of the nodes. The motivation of this work…

Signal Processing · Electrical Eng. & Systems 2020-02-18 Bo Jiang , Ashkan Panahi , Hamid Krim , Yiyi Yu , Spencer L. Smith

Functional connectivity (FC) has become a primary means of understanding brain functions by identifying brain network interactions and, ultimately, how those interactions produce cognitions. A popular definition of FC is by statistical…

Neuroimaging has profoundly enhanced our understanding of the human brain by characterizing its structure, function, and connectivity through modalities like MRI, fMRI, EEG, and PET. These technologies have enabled major breakthroughs…

Applications · Statistics 2026-02-16 Jian Kang , Thomas Nichols , Lexin Li , Martin A. Lindquist , Hongtu Zhu

Precise segmentation of brain tumors, particularly contrast-enhancing regions visible in post-contrast MRI (areas highlighted by contrast agent injection), is crucial for accurate clinical diagnosis and treatment planning but remains…

Image and Video Processing · Electrical Eng. & Systems 2025-06-13 Minye Shao , Zeyu Wang , Haoran Duan , Yawen Huang , Bing Zhai , Shizheng Wang , Yang Long , Yefeng Zheng

Characterizing the subtle changes of functional brain networks associated with the pathological cascade of Alzheimer's disease (AD) is important for early diagnosis and prediction of disease progression prior to clinical symptoms. We…

Neurons and Cognition · Quantitative Biology 2020-11-12 Mengjia Xu , David Lopez Sanz , Pilar Garces , Fernando Maestu , Quanzheng Li , Dimitrios Pantazis

Neuroimaging data can be represented as networks of nodes and edges that capture the topological organization of the brain connectivity. Graph theory provides a general and powerful framework to study these networks and their structure at…

Neurons and Cognition · Quantitative Biology 2017-05-19 Cécile Bordier , Carlo Nicolini , Angelo Bifone

Understanding how adult humans learn non-native speech categories such as tone information has shed novel insights into the mechanisms underlying experience-dependent brain plasticity. Scientists have traditionally examined these questions…

Methodology · Statistics 2020-06-16 Giorgio Paulon , Fernando Llanos , Bharath Chandrasekaran , Abhra Sarkar

Age estimation technology is a part of facial recognition and has been applied to identity authentication. This technology achieves the development and application of a juvenile anti-addiction system by authenticating users in the game.…

Computer Vision and Pattern Recognition · Computer Science 2023-10-13 Miaomiao Yang , Changwei Yao , Shijin Yan