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Protein folding is one of the age-old biological problems that refers to the mechanism of understanding and predicting how a protein's linear sequence of amino acids folds into its specific three dimensional structure.This structure is…

This work explores the potential of using differentiable simulation for learning quadruped locomotion. Differentiable simulation promises fast convergence and stable training by computing low-variance first-order gradients using robot…

Robotics · Computer Science 2024-10-16 Yunlong Song , Sangbae Kim , Davide Scaramuzza

Stochastic sampling based trackers have shown good performance for abrupt motion tracking so that they have gained popularity in recent years. However, conventional methods tend to use a two-stage sampling paradigm, in which the search…

Computer Vision and Pattern Recognition · Computer Science 2015-03-11 Tianfei Zhou , Yao Lu , Feng Lv , Huijun Di , Qingjie Zhao , Jian Zhang

Reinforcement learning has been demonstrated as a flexible and effective approach for learning a range of continuous control tasks, such as those used by robots to manipulate objects in their environment. But in robotics particularly,…

Robotics · Computer Science 2022-10-25 Tuluhan Akbulut , Max Merlin , Shane Parr , Benedict Quartey , Skye Thompson

Motion planning framed as optimisation in structured latent spaces has recently emerged as competitive with traditional methods in terms of planning success while significantly outperforming them in terms of computational speed. However,…

Robotics · Computer Science 2023-03-07 Jun Yamada , Chia-Man Hung , Jack Collins , Ioannis Havoutis , Ingmar Posner

We describe the results obtained from an improved model for protein folding. We find that a good agreement with the native structure of a 46 residue long, five-letter protein segment is obtained by carefully tuning the parameters of the…

Biomolecules · Quantitative Biology 2009-11-11 Andrea Nobile , Federico Rapuano

Retargeting human kinematic reference motion onto a robot's morphology remains a formidable challenge. Existing methods often produce physical inconsistencies, such as foot sliding, self-collisions, or dynamically infeasible motions, which…

Robotics · Computer Science 2026-05-08 David Müller , Agon Serifi , Sammy Christen , Ruben Grandia , Espen Knoop , Moritz Bächer

Many biologically important ligands of proteins are large, flexible, and often charged molecules that bind to extended regions on the protein surface. It is infeasible or expensive to locate such ligands on proteins with standard methods…

Motion prediction has been studied in different contexts with models trained on narrow distributions and applied to downstream tasks in human motion prediction and robotics. Simultaneously, recent efforts in scaling video prediction have…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Johnathan Xie , Stefan Stojanov , Cristobal Eyzaguirre , Daniel L. K. Yamins , Jiajun Wu

Proteins created by combinatorial methods in vitro are an important source of information for understanding sequence-structure-function relationships. Alignments of folded proteins from combinatorial libraries can be analyzed using methods…

Biomolecules · Quantitative Biology 2007-05-23 Jeffrey B. Endelman , Jesse D. Bloom , Christopher R. Otey , Marco Landwehr , Frances H. Arnold

To dynamically traverse challenging terrain, legged robots need to continually perceive and reason about upcoming features, adjust the locations and timings of future footfalls and leverage momentum strategically. We present a pipeline that…

Robotics · Computer Science 2021-04-20 Oliwier Melon , Romeo Orsolino , David Surovik , Mathieu Geisert , Ioannis Havoutis , Maurice Fallon

In this paper we present a novel probabilistic sampling-based motion planning algorithm called the Fast Marching Tree algorithm (FMT*). The algorithm is specifically aimed at solving complex motion planning problems in high-dimensional…

Robotics · Computer Science 2015-02-09 Lucas Janson , Edward Schmerling , Ashley Clark , Marco Pavone

There has been extensive progress in the reconstruction and generation of 4D scenes from monocular casually-captured video. While these tasks rely heavily on known camera poses, the problem of finding such poses using structure-from-motion…

Computer Vision and Pattern Recognition · Computer Science 2024-12-02 Lily Goli , Sara Sabour , Mark Matthews , Marcus Brubaker , Dmitry Lagun , Alec Jacobson , David J. Fleet , Saurabh Saxena , Andrea Tagliasacchi

The simulation of a protein's folding process is often done via stochastic local search, which requires a procedure to apply structural changes onto a given conformation. Here, we introduce a constraint-based approach to enumerate lattice…

Computational Engineering, Finance, and Science · Computer Science 2009-10-21 Martin Mann , Mohamed Abou Hamra , Kathleen Steinhöfel , Rolf Backofen

Understanding the principles of protein folding is a cornerstone of computational biology, with implications for drug design, bioengineering, and the understanding of fundamental biological processes. Lattice protein folding models offer a…

Disordered Systems and Neural Networks · Physics 2025-08-08 Shoummo Ahsan Khandoker , Estelle M. Inack , Mohamed Hibat-Allah

We present a method for efficient differentiable simulation of articulated bodies. This enables integration of articulated body dynamics into deep learning frameworks, and gradient-based optimization of neural networks that operate on…

Machine Learning · Computer Science 2021-09-17 Yi-Ling Qiao , Junbang Liang , Vladlen Koltun , Ming C. Lin

We present a novel Monte Carlo simulation of protein folding, in which all heavy atoms are represented as interacting hard spheres. This model includes all degrees of freedom relevant to folding - all sidechain and backbone torsions - and…

Soft Condensed Matter · Physics 2007-05-23 J. Shimada , E. L. Kussell , E. I. Shakhnovich

We propose a new architecture for the learning of predictive spatio-temporal motion models from data alone. Our approach, dubbed the Dropout Autoencoder LSTM, is capable of synthesizing natural looking motion sequences over long time…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Partha Ghosh , Jie Song , Emre Aksan , Otmar Hilliges

While motion planning of locomotion for legged robots has shown great success, motion planning for legged robots with dexterous multi-finger grasping is not mature yet. We present an efficient motion planning framework for simultaneously…

Robotics · Computer Science 2023-01-18 Yuki Shirai , Xuan Lin , Alexander Schperberg , Yusuke Tanaka , Hayato Kato , Varit Vichathorn , Dennis Hong

We present the development of the idea to use dynamics in the space of contact maps as a computational approach to the protein folding problem. We first introduce two important technical ingredients, the reconstruction of a three…

Soft Condensed Matter · Physics 2009-10-31 Michele Vendruscolo , Eytan Domany
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