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We use a recently proposed staggered difference-in-differences approach to investigate effects of adoption of an online consultation system in English general practice on antibiotic prescribing patterns. The target estimand is the average…

Applications · Statistics 2023-06-02 Kate B. Ellis , Ruth H. Keogh , Geraldine M. Clarke , Stephen O'Neill

Tuberculosis (TB) is the world's deadliest infectious disease, with over 1.5 million deaths annually and 10 million new cases reported each year. The causative organism, Mycobacterium tuberculosis (Mtb) can take nearly 40 days to culture, a…

Antibiotic-resistant bacteria has posed a grave threat to public health by causing a number of nosocomial infections in hospitals. Mathematical models have been used to study the transmission of antibiotic-resistant bacteria within a…

Populations and Evolution · Quantitative Biology 2016-10-06 Xiuli Cen , Zhilan Feng , Yiqiang Zheng , Yulin Zhao

Early identification of individuals at elevated risk of Chlamydia trachomatis infection may enable optimal use of molecular testing in resource-aware screening. We evaluate the feasibility of pre-test risk stratification (PTRS) using…

Machine Learning · Computer Science 2026-05-19 Mehrab Mahdian , Marko Lehes , Katrin Krolov , Tamas Pardy

Antimicrobial resistance (AMR) poses a mounting global health crisis, requiring rapid and reliable prediction frameworks that capture its complex evolutionary dynamics. Traditional antimicrobial susceptibility testing (AST), while accurate,…

Populations and Evolution · Quantitative Biology 2025-11-18 Anshul Bagaria

Antibiotic Resistance (AR) is a critical global health challenge that necessitates the development of cost-effective, efficient, and accurate diagnostic tools. Given the genetic basis of AR, techniques such as Polymerase Chain Reaction…

Quantitative Methods · Quantitative Biology 2025-02-24 David Hagerman , Anna Johnning , Roman Naeem , Fredrik Kahl , Erik Kristiansson , Lennart Svensson

Throughout the Covid-19 pandemic, a significant amount of effort had been put into developing techniques that predict the number of infections under various assumptions about the public policy and non-pharmaceutical interventions. While…

Computers and Society · Computer Science 2021-12-22 Sharare Zehtabian , Siavash Khodadadeh , Damla Turgut , Ladislau Bölöni

Machine learning has become an important component for many systems and applications including computer vision, spam filtering, malware and network intrusion detection, among others. Despite the capabilities of machine learning algorithms…

Machine Learning · Statistics 2018-02-14 Andrea Paudice , Luis Muñoz-González , Andras Gyorgy , Emil C. Lupu

The translation of comparative genomics into clinical decision support tools often depends on the quality of sequence alignments. However, currently used methods of multiple sequence alignments suffer from significant biases and problems…

Genomics · Quantitative Biology 2023-11-30 Manal Helal , Vitali Sintchenko

In several medical decision-making problems, such as antibiotic prescription, laboratory testing can provide precise indications for how a patient will respond to different treatment options. This enables us to "fully observe" all potential…

Machine Learning · Computer Science 2020-08-14 Soorajnath Boominathan , Michael Oberst , Helen Zhou , Sanjat Kanjilal , David Sontag

Machine learning is a tool for building models that accurately represent input training data. When undesired biases concerning demographic groups are in the training data, well-trained models will reflect those biases. We present a…

Machine Learning · Computer Science 2018-01-25 Brian Hu Zhang , Blake Lemoine , Margaret Mitchell

Whether evolution can be predicted is a key question in evolutionary biology. Here we set out to better understand the repeatability of evolution. We explored experimentally the effect of mutation supply and the strength of selective…

Populations and Evolution · Quantitative Biology 2017-09-13 Thomas van Dijk , Sungmin Hwang , Joachim Krug , J. Arjan G. M. de Visser , Mark P. Zwart

Algorithms learned from data are increasingly used for deciding many aspects in our life: from movies we see, to prices we pay, or medicine we get. Yet there is growing evidence that decision making by inappropriately trained algorithms may…

Artificial Intelligence · Computer Science 2017-08-03 Indre Zliobaite

Student dropout is a significant concern for educational institutions due to its social and economic impact, driving the need for risk prediction systems to identify at-risk students before enrollment. We explore the accuracy of such…

Antibiotic resistance is a major threat to global health. It emerges in multispecies microbial communities under antibiotic exposure. This makes antibiotic spectrum -- a drug's distribution of effects across species -- a potential key…

Populations and Evolution · Quantitative Biology 2026-04-21 Magnus Aspenberg , Erik Andreas Martens , Kristofer Wollein Waldetoft

Sepsis is a life-threatening organ malfunction caused by the host's inability to fight infection, which can lead to death without proper and immediate treatment. Therefore, early diagnosis and medical treatment of sepsis in critically ill…

Machine Learning · Computer Science 2023-04-14 Kevin Ewig , Xiangwen Lin , Tucker Stewart , Katherine Stern , Grant O'Keefe , Ankur Teredesai , Juhua Hu

Present study is dedicated to the problem of electrochemical analysis of multicomponent mixtures such as milk. A combination of cyclic voltammetry facilities and machine learning technique made it possible to create a pattern recognition…

Machine learning has become an increasingly powerful tool for solving complex problems, and its application in public health has been underutilized. The objective of this study is to test the efficacy of a machine-learned model of foodborne…

Clinical predictive algorithms are increasingly being used to form the basis for optimal treatment policies--that is, to enable interventions to be targeted to the patients who will presumably benefit most. Despite taking advantage of…

Applications · Statistics 2020-07-21 Ben J. Marafino , Alejandro Schuler , Vincent X. Liu , Gabriel J. Escobar , Mike Baiocchi

Diagnosis of fungal infections can rely on microscopic examination, however, in many cases, it does not allow unambiguous identification of the species due to their visual similarity. Therefore, it is usually necessary to use additional…

Computer Vision and Pattern Recognition · Computer Science 2020-10-14 Bartosz Zieliński , Agnieszka Sroka-Oleksiak , Dawid Rymarczyk , Adam Piekarczyk , Monika Brzychczy-Włoch
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