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Ion transport through nanopores permeates through many areas of science and technology, from cell behavior to sensing and separation to catalysis and batteries. Two-dimensional materials, such as graphene, molybdenum disulfide (MoS$_2$),…

Mesoscale and Nanoscale Physics · Physics 2019-07-19 Subin Sahu , Michael Zwolak

The current-voltage characteristics of the alpha-Hemolysin protein pore during the passage of single-stranded DNA under varying ionic strength, C, are studied experimentally. We observe strong blockage of the current, weak super-linear…

Soft Condensed Matter · Physics 2009-11-11 Douwe Jan Bonthuis , Jingshan Zhang , Breton Hornblower , Jerome Mathe , Boris I. Shklovskii , Amit Meller

Nanopores in 2D materials are highly desirable for DNA sequencing, yet achieving single-stranded DNA (ssDNA) transport through them is challenging. Using density functional theory calculations and molecular dynamics simulations we show that…

Mesoscale and Nanoscale Physics · Physics 2021-09-29 Alex Smolyanitsky , Binquan Luan

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of…

Soft Condensed Matter · Physics 2015-06-25 Johan Lagerqvist , Michael Zwolak , Massimiliano Di Ventra

The complex mechanisms governing charge migration in DNA oligomers reflect the rich structural and electronic properties of the molecule of life. Controlling the mechanical stability of DNA nanowires in charge transport experiments is a…

Mesoscale and Nanoscale Physics · Physics 2015-05-13 Bo Song , Marcus Elstner , Gianaurelio Cuniberti

We studied the unzipping kinetics of single molecules of double-stranded DNA by pulling one of their two strands through a narrow protein pore. PCR analysis yielded the first direct proof of DNA unzipping in such a system. The time to unzip…

Soft Condensed Matter · Physics 2009-11-07 Alexis F. Sauer-Budge , Jacqueline A. Nyamwanda , David K. Lubensky , Daniel Branton

We study the electrokinetics of a single polyelectrolyte chain in salt solution using hydrodynamic simulations. The salt-dependent chain mobility compares well with experimental DNA data. The mobility of condensed counterions exhibits a…

Soft Condensed Matter · Physics 2009-05-26 Sebastian Fischer , Ali Naji , Roland R. Netz

When the DNA double helix is subjected to external forces it can stretch elastically to elongations reaching 100% of its natural length. These distortions, imposed at the mesoscopic or macroscopic scales, have a dramatic effect on…

Materials Science · Physics 2009-11-13 Ryan Barnett , Paul Maragakis , Ari Turner , Maria Fyta , Efthimios Kaxiras

This paper aims at a comprehensive understanding on the novel elastic property of double-stranded DNA (dsDNA) discovered very recently through single-molecule manipulation techniques. A general elastic model for double-stranded biopolymers…

Soft Condensed Matter · Physics 2009-10-31 Haijun Zhou , Yang Zhang , Zhong-can Ou-Yang

We study the effect of volumetric constraints on the structure and electronic transport properties of distilled water in a nanopore with embedded electrodes. Combining classical molecular dynamics simulations with quantum scattering theory,…

Soft Condensed Matter · Physics 2014-01-30 P. Boynton , M. Di Ventra

The problem of DNA$-$DNA interaction mediated by divalent counterions is studied using a generalized Grand-canonical Monte-Carlo simulation for a system of two salts. The effect of the divalent counterion size on the condensation behavior…

Biomolecules · Quantitative Biology 2016-02-19 Toan T. Nguyen

Transport properties of artificial solids composed of colloidal CdSe nanocrystals (NCs) are studied from 6 K to 250 K, before and after annealing. Annealing results in greatly enhanced dark and photocurrent in NC solids, while transmission…

Mesoscale and Nanoscale Physics · Physics 2009-11-07 M. Drndic , M. Vitasovic , N. Y. Morgan , M. A. Kastner , M. G. Bawendi

DNA unzipping by nanopore translocation has implications in diverse contexts, from polymer physics to single-molecule manipulation to DNA-enzyme interactions in biological systems. Here we use molecular dynamics simulations and a…

Soft Condensed Matter · Physics 2025-01-29 Antonio Suma , Cristian Micheletti

The fabrication of nanopores in atomically-thin graphene has recently been achieved and translocation of DNA has been demonstrated. Taken together with an earlier proposal to use graphene nanogaps for the purpose of DNA sequencing, this…

Instrumentation and Detectors · Physics 2011-05-16 Jariyanee Prasongkit , Anton Grigoriev , Biswarup Pathak , Rajeev Ahuja , Ralph H. Scheicher

This study reveals that, in strong coulomb coupling regime, bending a straight and fully overcharged DNA (up to its maximal acceptance by multivalent counterions) to a circle releases some of the adsorbed (correlated)counterions but still…

Soft Condensed Matter · Physics 2013-07-31 Arup K Mukherjee

Tunable nanopores in elastomeric membranes have been used to study the dependence of ionic current blockade rate on the concentration and electrophoretic mobility of particles in aqueous suspensions. A range of nanoparticle sizes, materials…

Soft Condensed Matter · Physics 2010-05-25 G R Willmott , R Vogel , S S C Yu , L G Groenewegen , G S Roberts , D Kozak , W Anderson , M Trau

We revisit the theory of ion transport in parallel-plate channels and also discuss how the wettability of a solid and the mobility of adsorbed surface charges impact the transport of ions. It is shown that depending on the ratio of the…

Soft Condensed Matter · Physics 2021-09-29 Olga I. Vinogradova , Elena F. Silkina , Evgeny S. Asmolov

Changes in the medium of biological cell nucleus under ion beam action is considered as a possible cause of cell functioning disruption in the living body. As the most long-lived molecular product appeared in the cell after the passage of…

Biological Physics · Physics 2015-06-12 D. V. Piatnytskyi , O. O. Zdorevskyi , S. M. Perepelytsya , S. N. Volkov

Based on our formulation of the DNA electrophoresis near a pore [P. Rowghanian and A. Y. Grosberg, Phys. Rev. E 87, 042723 (2013)], we address the electrophoretic DNA capture into a nanopore as a steady-state process of particle absorption…

Biological Physics · Physics 2013-06-20 Payam Rowghanian , Alexander Y. Grosberg

The advent of solid state nanodevices allows for interrogating the physico-chemical properties of a polyelectrolyte chain by electrophoretically driving it through a nanopore. Salient dynamical aspects of the translocation process have been…

Soft Condensed Matter · Physics 2015-06-05 A. Rosa , M. Di Ventra , C. Micheletti