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In recent years, deep learning revolutionized machine learning and its applications, producing results comparable to human experts in several domains, including neuroscience. Each year, hundreds of scientific publications present…

Quantitative Methods · Quantitative Biology 2023-01-13 Louis Fabrice Tshimanga , Manfredo Atzori , Federico Del Pup , Maurizio Corbetta

Human-in-the-loop data analysis applications necessitate greater transparency in machine learning models for experts to understand and trust their decisions. To this end, we propose a visual analytics workflow to help data scientists and…

Machine Learning · Statistics 2017-10-03 Josua Krause , Aritra Dasgupta , Jordan Swartz , Yindalon Aphinyanaphongs , Enrico Bertini

Program synthesis is an active research field in academia, national labs, and industry. Yet, work directly applicable to scientific computing, while having some impressive successes, has been limited. This report reviews the relevant areas…

Machine Learning · Computer Science 2021-02-03 Hal Finkel , Ignacio Laguna

In the world of science new technology have opened up the possibility to rely on advanced computational methods and models to conduct and produce scientific research. An important aspect of scientific and business workflows is provenance -…

Software Engineering · Computer Science 2025-04-01 Ludwig Stage , Julia Dahlberg , Dimka Karastoyanova

The extraction of molecular structures and reaction data from scientific documents is challenging due to their varied, unstructured chemical formats and complex document layouts. To address this, we introduce MolMole, a vision-based deep…

Computational methods and associated software implementations are central to every field of scientific investigation. Modern biological research, particularly within systems biology, has relied heavily on the development of software tools…

Computers and Society · Computer Science 2025-03-07 Kit Gallagher , Richard Creswell , Ben Lambert , Martin Robinson , Chon Lok Lei , Gary R. Mirams , David J. Gavaghan

Artificial intelligence is transforming molecular and materials science, but its growing computational and data demands raise critical sustainability challenges. In this Perspective, we examine resource considerations across the AI-driven…

The existing approaches for scientific workflows composition face the problems of domain knowledge integration. By this paper we summarize the results, which have been elaborated and implemented during the 2-year research concerning to…

Software Engineering · Computer Science 2016-06-28 Pavel A. Smirnov , Sergey V. Kovalchuk , Alexander V. Boukhanovsky

Development and homeostasis in multicellular systems both require exquisite control over spatial molecular pattern formation and maintenance. Advances in spatially-resolved and high-throughput molecular imaging methods such as multiplexed…

Quantitative Methods · Quantitative Biology 2023-03-30 Alex J. Lee , Robert Cahill , Reza Abbasi-Asl

For many macromolecular systems the accurate sampling of the relevant regions on the potential energy surface cannot be obtained by a single, long Molecular Dynamics (MD) trajectory. New approaches are required to promote more efficient…

Computational Engineering, Finance, and Science · Computer Science 2016-06-02 Vivekanandan Balasubramanian , Iain Bethune , Ardita Shkurti , Elena Breitmoser , Eugen Hruska , Cecilia Clementi , Charles Laughton , Shantenu Jha

Nextflow is a workflow management system commonly used in fields like bioinformatics and earth observation. It coordinates distributed data processing of various tools as an acyclic sequence of tasks while using, containerization (e.g.,…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-01 Sami Kharma , Tobias Wies , Florian Schintke

Machine learning has been increasingly applied in climate modeling on system emulation acceleration, data-driven parameter inference, forecasting, and knowledge discovery, addressing challenges such as physical consistency, multi-scale…

Simulation has become an essential component of designing and developing scientific experiments. The conventional procedural approach to coding simulations of complex experiments is often error-prone, hard to interpret, and inflexible,…

Computational Physics · Physics 2023-08-09 Peter Sun , John A. Marohn

The development and deployment of safe and dependable AI models is crucial in applications where functional safety is a key concern. Given the rapid advancement in AI research and the relative novelty of the safe-AI domain, there is an…

Software Engineering · Computer Science 2025-03-21 Suzana Veljanovska , Hans Dermot Doran

Agile software development principles and values have been widely adopted across various industries, influencing products and services globally. Despite its increasing popularity, a significant gap remains between research and practical…

Software Engineering · Computer Science 2025-07-16 Michael Neumann , Eva-Maria Schön , Mali Senapathi , Maria Rauschenberger , Tiago Silva da Silva

Molecules play a crucial role in biomedical research and discovery, particularly in the field of small molecule drug development. Given the rapid advancements in large language models, especially the recent emergence of reasoning models, it…

Artificial Intelligence · Computer Science 2025-12-12 Chenyang Zuo , Siqi Fan , Zaiqing Nie

Successful implementation of active learning strategies in the engineering classroom -- and in particular in certain subjects which are highly technological in nature such as, for instance, rocket engines and space propulsion -- means…

Computational Engineering, Finance, and Science · Computer Science 2021-04-21 Juan M. Tizón , Pablo Sierra , Luis Sánchez de León , Emilio Navarro , Javier Vilá , José F. Moral

University research groups in Computational Science and Engineering (CSE) generally lack dedicated funding and personnel for Research Software Engineering (RSE), which, combined with the pressure to maximize the number of scientific…

Drying of biologically-relevant sessile droplets, including passive systems (like DNA and proteins), as well as active microbial systems comprising bacteria and algae, have garnered considerable attention over the last decades. Distinct…

Soft Condensed Matter · Physics 2023-11-07 Anusuya Pal , Amalesh Gope , Anupam Sengupta

Machine learning (ML) applications become increasingly common in many domains. ML systems to execute these workloads include numerical computing frameworks and libraries, ML algorithm libraries, and specialized systems for deep neural…