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In this paper, to unveil interpretable development-specific gene signatures in human PFC, we propose a novel gene selection method, named Interpretable Causality Gene Selection (ICGS), which adopts a Bayesian Network (BN) to represent…

Neurons and Cognition · Quantitative Biology 2022-11-18 Meng Huang , Xiucai Ye , Tetsuya Sakurai

A structural equation model (SEM) is an effective framework to reason over causal relationships represented via a directed acyclic graph (DAG). Recent advances have enabled effective maximum-likelihood point estimation of DAGs from…

Machine Learning · Computer Science 2021-12-07 Chris Cundy , Aditya Grover , Stefano Ermon

Dual-encoder (DE) models are widely used in retrieval tasks, most commonly studied on open QA benchmarks that are often characterized by multi-class and limited training data. In contrast, their performance in multi-label and data-rich…

Machine Learning · Computer Science 2024-03-19 Nilesh Gupta , Devvrit Khatri , Ankit S Rawat , Srinadh Bhojanapalli , Prateek Jain , Inderjit Dhillon

Causal decomposition analysis provides a way to identify mediators that contribute to health disparities between marginalized and non-marginalized groups. In particular, the degree to which a disparity would be reduced or remain after…

Methodology · Statistics 2021-09-16 Soojin Park , Suyeon Kang , Chioun Lee

The ever-increasing demand for broadband Internet access has motivated the further development of the digital subscriber line to the G.fast standard in order to expand its operational band from 106 MHz to 212 MHz. Conventional far-end…

Information Theory · Computer Science 2018-06-18 Jiankang Zhang , Sheng Chen , Rong Zhang , Anas F. Al Rawi , Lajos Hanzo

Biomedical sciences are increasingly recognising the relevance of gene co-expression-networks for analysing complex-systems, phenotypes or diseases. When the goal is investigating complex-phenotypes under varying conditions, it comes…

Model discovery aims to uncover governing differential equations of dynamical systems directly from experimental data. Benchmarking such methods is essential for tracking progress and understanding trade-offs in the field. While prior…

Machine Learning · Computer Science 2026-01-27 Amirmohammad Ziaei Bideh , Aleksandra Georgievska , Jonathan Gryak

The discovery of peptides having high biological activity is very challenging mainly because there is an enormous diversity of compounds and only a minority have the desired properties. To lower cost and reduce the time to obtain promising…

Quantitative Methods · Quantitative Biology 2014-04-11 Sébastien Giguère , François Laviolette , Mario Marchand , Denise Tremblay , Sylvain Moineau , Éric Biron , Jacques Corbeil

Multiplex brightfield imaging offers the advantage of simultaneously analyzing multiple biomarkers on a single slide, as opposed to single biomarker labeling on multiple consecutive slides. To accurately analyze multiple biomarkers…

Image and Video Processing · Electrical Eng. & Systems 2024-08-16 Satarupa Mukherjee , Jim Martin , Yao Nie

Feature or variable selection is a problem inherent to large data sets. While many methods have been proposed to deal with this problem, some can scale poorly with the number of predictors in a data set. Screening methods scale linearly…

Methodology · Statistics 2023-01-09 Naveed Merchant , Jeffrey D. Hart

Microarray technology is known as one of the most important tools for collecting DNA expression data. This technology allows researchers to investigate and examine types of diseases and their origins. However, microarray data are often…

Quantitative Methods · Quantitative Biology 2021-01-05 Babak Nouri-Moghaddam , Mehdi Ghazanfari , Mohammad Fathian

Understanding causal relationships between variables is fundamental across scientific disciplines. Most causal discovery algorithms rely on two key assumptions: (i) all variables are observed, and (ii) the underlying causal graph is…

Machine Learning · Computer Science 2026-01-26 Muralikrishnna G. Sethuraman , Faramarz Fekri

Sensory input from multiple sources is crucial for robust and coherent human perception. Different sources contribute complementary explanatory factors. Similarly, research studies often collect multimodal imaging data, each of which can…

Comparative transcriptomics has gained increasing popularity in genomic research thanks to the development of high-throughput technologies including microarray and next-generation RNA sequencing that have generated numerous transcriptomic…

Quantitative Methods · Quantitative Biology 2021-12-01 Wei Vivian Li , Yiling Chen , Jingyi Jessica Li

Independence screening methods such as the two sample $t$-test and the marginal correlation based ranking are among the most widely used techniques for variable selection in ultrahigh dimensional data sets. In this short note, simple…

Methodology · Statistics 2020-11-17 Run Wang , Somak Dutta , Vivekananda Roy

In tumoral cells, gene regulation mechanisms are severely altered, and these modifications in the regulations may be characteristic of different subtypes of cancer. However, these alterations do not necessarily induce differential…

This paper introduces a novel method leveraging bi-encoder-based detectors along with a comprehensive study comparing different out-of-distribution (OOD) detection methods in NLP using different feature extractors. The feature extraction…

Computation and Language · Computer Science 2024-03-14 Louis Owen , Biddwan Ahmed , Abhay Kumar

In clinical practice, multiple biomarkers are often measured on the same subject for disease diagnosis, and combining them can improve diagnostic accuracy. Existing studies typically combine multiple biomarkers by maximizing the Area Under…

Methodology · Statistics 2025-02-25 Ao Sun , Yanting Li , Xiao-Hua Zhou

The practical utility of causality in decision-making is widespread and brought about by the intertwining of causal discovery and causal inference. Nevertheless, a notable gap exists in the evaluation of causal discovery methods, where…

Machine Learning · Computer Science 2023-08-01 Chris Chinenye Emezue , Alexandre Drouin , Tristan Deleu , Stefan Bauer , Yoshua Bengio

During drug development, evidence can emerge to suggest a treatment is more effective in a specific patient subgroup. Whilst early trials may be conducted in biomarker-mixed populations, later trials are more likely to enrol…

Methodology · Statistics 2023-06-07 Lorna Wheaton , Dan Jackson , Sylwia Bujkiewicz